A5104060096- Agronomic Practices and Intercropping Systems
- Genetics and Neurodevelopmental Disorders
- Genetic factors in colorectal cancer
- European Criminal Justice and Data Protection
- Criminal Law and Policy
- Agriculture and Rural Development Research
- Cancer Genomics and Diagnostics
- Law and Political Science
- North African History and Literature
- African history and culture studies
- Digitalization, Law, and Regulation
- Plant Molecular Biology Research
- Linguistic and Sociocultural Studies
- Seed Germination and Physiology
- Historical and Literary Analyses
- Protein Degradation and Inhibitors
- Soil Carbon and Nitrogen Dynamics
- Multiculturalism, Politics, Migration, Gender
- European and International Law Studies
- Legume Nitrogen Fixing Symbiosis
- Agriculture Sustainability and Environmental Impact
- Criminal Law and Evidence
- Colorectal Cancer Screening and Detection
- Greenhouse Technology and Climate Control
- Light effects on plants
Lettres, arts du spectacle, langues romanes
2013-2024
Université de Caen Normandie
2019-2023
Terres Univia
2013-2023
Memorial Sloan Kettering Cancer Center
2023
Normandie Université
2023
University of Mannheim
2020-2021
Hôpitaux Universitaires de Strasbourg
2000-2020
Institut de recherche en horticulture et semences
2018-2020
Institut Agro Rennes-Angers
2020
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2020
Aging weakens memory functions. Exposing healthy rodents or pathological rodent models to environmental enrichment (EE) housing improves their cognitive functions by changing neuronal levels of excitation, cellular signaling, and plasticity, notably in the hippocampus. At molecular level, brain derived-neurotrophic factor (BDNF) represents an important player that supports EE-associated changes. EE facilitation learning was also shown correlate with chromatin acetylation It is not known,...
The recent literature provides evidence that epigenetic mechanisms such as DNA methylation and histone modification are crucial to gene transcription linked synaptic plasticity in the mammalian brain--notably hippocampus--and memory formation. We measured global acetylation levels rat hippocampus at an early stage of spatial or fear found H3, H4 H2B underwent differential specific sites depending on whether rats had been exposed context a task without having learn about place therein:...
Abstract The majority of lung cancer patients have tumor‐derived genetic alterations in circulating plasma DNA that could be exploited as a diagnostic tool. We used fluorescent microsatellite analysis to detect and tumor 34 who underwent bronchoscopy for cancer, including 11 small cell (SCLC) 23 nonsmall (NSCLC) (12 adenocarcinomas, squamous carcinomas) 20 controls. Allelotyping was performed with selected panel 12 microsatellites from 9 chromosomal regions 3p21, 3p24, 5q, 9p, 9q, 13q, 17p,...
Kv2.2, homologous to the shab family of Drosophila voltage-gated K + channels, was isolated from human and canine colonic circular smooth muscle-derived mRNA. Northern hybridization analysis performed on RNA prepared tissues RT-PCR dispersed selected muscle cells demonstrate that Kv2.2 is expressed in found all regions gastrointestinal (GI) tract several vascular tissues. Injection mRNA into Xenopus oocytes resulted expression a slowly activating current (time half maximum current, 97 ± 8.6...
Topoisomerase I is a privileged target for widely used anticancer agents such as irinotecan. Although these drugs are classically considered to be DNA-damaging agents, increasing evidence suggests that they might also influence the tumor environment. This study evaluates in vivo cellular and molecular modifications induced by irinotecan, topoisomerase I-directed agent, patient-derived colon tumors subcutaneously implanted athymic nude mice. Irinotecan was given intraperitoneally at 40 mg/kg...
Abstract Cell–cell adhesions constitute the structural “glue” that retains cells together and contributes to tissue organisation physiological function. The integrity of these structures is regulated by extracellular intracellular signals pathways act on functional units cell adhesion such as molecules/adhesion receptors, matrix (ECM) proteins cytoplasmic plaque/peripheral membrane proteins. In advanced cancer, regulatory are dysregulated lead cell–cell disassembly, increased invasion...
Urine, breast milk, plasma, and serum have been shown to contain cell-free DNA (1)(2)(3)(4)(5)(6)(7). For plasma detection, several recent studies addressed the need for careful evaluation standardization of preanalytical processes (8)(9)(10)(11)(12). Key problems appear, such as possible contamination by white blood cells; generally low variable amount circulating DNA, making extraction/quantification difficult time-consuming; poor quality; presence PCR inhibitors. In any case, automation...
The DNA origami technique offers great potential for nanotechnology. Using biomolecular self-assembly, defined 2D and 3D nanoscale structures can be realized. allows the positioning of proteins, fluorophores or nanoparticles with an accuracy a few nanometers enables thereby novel devices. Origami assembly usually includes thermal denaturation step at 90 °C. Additional components used (such as proteins) are often thermosensitive, possibly damaged by such harsh conditions. They have therefore...
Coffin-Lowry syndrome is a syndromic form of mental retardation caused by mutations the Rps6ka3 gene encoding ribosomal s6 kinase (RSK)2. RSK2 belongs to family containing four members in mammals: RSK1-4. RSKs are serine/threonine kinases and cytosolic substrates extracellular signal-regulated (ERK) Ras/MAPK signaling pathway. highly expressed hippocampus, mrsk2_KO mice display spatial learning memory impairment. In present study, we provide evidence abnormally increased phosphorylation...
Shoot architecture is a key component of the interactions between plants and their environment. We present novel model grass, which fully integrates shoot morphogenesis metabolism carbon (C) nitrogen (N) at organ scale, within three-dimensional representation plant architecture. Plant seen as self-regulated system driven by two main mechanisms. First, rate extension establishment architectural traits are regulated concentrations C N metabolites in growth zones temperature. Second, timing...
Since the recent development of biologic agents targeting oncogenes, increasing attention has been focused on determining role tyrosine kinase receptors in pathogenesis tumors. Our study was designed to investigate status region 4q12, which contains candidate gene c-kit, and expression c-kit by immunohistochemistry (IHC).Paired blood biopsy specimens 68 children treated for high-grade primary osteosarcomas were collected. Microsatellite analysis at two genomic sites containing performed...
Simplified rotations often select weed flora consisting of one or several dominant species. In mainly winter cereals, the most frequent weeds in Atlantic European countries is blackgrass (<i>Alopecurus myosuroides<i/> Huds.). order to reduce environmental impacts and avoid selection herbicide-resistant populations, alternative management strategies are necessary. The objective present study was develop a methodology for using dynamics model called ALOMYSYS evaluating prospective diversified...