A5082928676- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Bioinformatics and Genomic Networks
- Stress Responses and Cortisol
- Neurotransmitter Receptor Influence on Behavior
- RNA Research and Splicing
- Genetic Associations and Epidemiology
- Single-cell and spatial transcriptomics
- Memory and Neural Mechanisms
- Autism Spectrum Disorder Research
- Cancer-related molecular mechanisms research
- Molecular Biology Techniques and Applications
- MicroRNA in disease regulation
- Dementia and Cognitive Impairment Research
Lieber Institute for Brain Development
2023-2024
University of Bari Aldo Moro
2022-2024
Université de Strasbourg
2021-2022
Centre National de la Recherche Scientifique
2021-2022
Laboratoire de Neurosciences Cognitives et Adaptatives
2021-2022
Schizophrenia is a neurodevelopmental brain disorder whose genetic risk associated with shifting clinical phenomena across the life span. We investigated convergence of putative schizophrenia genes in coexpression networks postmortem human prefrontal cortex (DLPFC), hippocampus, caudate nucleus, and dentate gyrus granule cells, parsed by specific age periods (total
A critical challenge in current research on Alzheimer's disease (AD) is to clarify the relationship between network dysfunction and emergence of subtle memory deficits itspreclinical stage. The AppNL-F/MAPT double knock-in (dKI) model with humanized β-amyloid peptide (Aβ) tau was used investigate both dysfunctions at an early Young male dKI mice (2 6 months) were tested three tasks taxing different aspects recognition affected preclinical AD. An deficit first appeared object-place...
MiR-137 is a microRNA involved in brain development, regulating neurogenesis and neuronal maturation. Genome-Wide Association Studies implicate miR-137 schizophrenia risk but do not explain its involvement function underlying biology. Polygenic for mediated by targets associated with working memory, although other evidence points to emotion processing. We characterized the functional correlates of target genes while disentangling previously reported associations memory Using RNA-sequencing...
Upon stress exposure, a broad network of structures comes into play in order to provide adequate responses and restore homeostasis. It has been known for decades that the main engaged during response are medial prefrontal cortex, amygdala, hippocampus, hypothalamus, monoaminergic systems (noradrenaline, dopamine serotonin) periaqueductal gray. The lateral habenula (LHb) is an epithalamic structure directly connected cortical areas whereas it functionally interacts with hippocampus. Also,...
Abstract RNA-sequencing studies of brain tissue homogenates have shed light on the molecular processes underlying schizophrenia (SCZ) but lack biological granularity at cell type level. Laser capture microdissection (LCM) can isolate selective populations with intact bodies to allow complementary gene expression analyses mRNA and protein. We used LCM collect excitatory neuron-enriched samples from CA1 subiculum (SUB) hippocampus layer III dorsolateral prefrontal cortex (DLPFC), which we...
Abstract Upon stress exposure a broad network of structures comes into play in order to provide adequate responses and restore homeostasis. It has been known for decades that the main engaged during response are medial prefrontal cortex, amygdala, hippocampus, hypothalamus, monoaminergic systems (noradrenaline, dopamine, serotonin), periaqueductal gray. The lateral habenula (LHb) is an epithalamic structure directly connected cortical areas whereas it functionally interacts with hippocampus....
Abstract A critical challenge in current research on AD is to clarify the relationship between early neuropathology and network dysfunction associated emergence of subtle memory alterations which announce disease onset. In present work, new generation App NL-F / MAPT double knock (dKI) model was used evaluate stages AD. The initial step tau pathology restricted perirhinal-entorhinal region, sparing hippocampus. This discrete neuropathological sign with deficits object-place associative...