A5075349550- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Stress Responses and Cortisol
- Retinoids in leukemia and cellular processes
- Receptor Mechanisms and Signaling
- Cholinesterase and Neurodegenerative Diseases
- Mitochondrial Function and Pathology
- Retinal Development and Disorders
- Neurotransmitter Receptor Influence on Behavior
- Olfactory and Sensory Function Studies
- Photoreceptor and optogenetics research
- Sleep and Wakefulness Research
- Glaucoma and retinal disorders
- NF-κB Signaling Pathways
- Estrogen and related hormone effects
- Pituitary Gland Disorders and Treatments
- Visual perception and processing mechanisms
- Chemokine receptors and signaling
- Nicotinic Acetylcholine Receptors Study
- Phosphodiesterase function and regulation
- ATP Synthase and ATPases Research
- Nuclear Receptors and Signaling
- Cognitive Science and Mapping
- Biochemical Acid Research Studies
Douglas Mental Health University Institute
2015-2022
McGill University
2015-2022
Laboratoire de Neurosciences Cognitives et Adaptatives
2013-2017
Université de Strasbourg
2010-2017
Centre National de la Recherche Scientifique
2013-2017
Laboratoire de Neurosciences Cognitives
2013
Aβ is unable to account for all aspects of cognitive impairments in a pre-plaque mouse model Alzheimer’s disease.
Spatial reference memory in rodents represents a unique opportunity to study brain mechanisms responsible for encoding, storage and retrieval of memory. Even though its reliance on hippocampal networks has long been established, the precise computations performed by different subfields during spatial learning are still not clear. To evolution electrophysiological activity CA1-dentate gyrus axis dorsal hippocampus over an iterative paradigm, we recorded local field potentials behaving mice...
Efficient spatial navigation relies on the hippocampus integrating local (proximal) and global (distal) cues, collectively called frames of reference, to guide behavior support memory. Although these cues control anchoring principal cell fields, how tune interneuron functions remains unknown. Traditionally, interneurons such as O-LM VIP cells have been viewed primarily speed encoders, although some also encode information or respond discrete stimuli. Using calcium imaging in freely behaving...
Brain mechanisms compensating for cerebral lesions may mitigate the progression of chronic neurodegenerative disorders such as Alzheimer's disease (AD). Mild cognitive impairment (MCI), which often precedes AD, is characterized by neuronal loss in entorhinal cortex (EC). This leads to a hippocampal disconnection syndrome that drives clinical progression. The concomitant sprouting cholinergic terminals hippocampus has been proposed compensate reduced EC glutamatergic input. However, absence...
G protein-coupled receptor (GPCR) associated sorting protein-1 (GASP-1) is suspected to play a key role in recycling and degradation of several GPCRs. In previous study, we have shown that GASP-1-knock-out (GASP-1-KO) mice displayed deficits acquiring cocaine self-administration task, with an exacerbated down-regulation striatal dopaminergic cholinergic receptors. Among possibilities, GASP-1 deficiency could impaired memory processes underlying the acquisition operant conditioning task....
The superior colliculus is a hub for multisensory integration necessary visuo-spatial orientation, control of gaze movements and attention. multiple functions the have prompted hypotheses about its involvement in neuropsychiatric conditions, but to date, this topic has not been addressed experimentally. We describe experiments on genetically modified mice, Isl2-EphA3 knock-in line, that show well-characterized duplication retino-collicular cortico-collicular axonal projections leading...
ABSTRACT The medial septum (MS), a brain region containing acetylcholine, GABA and glutamate neurons, is essential for learning memory. However, whether MS neurons contribute to memory unknown. Here, we use calcium imaging optogenetic silencing determine the function of in mice performing spatial allocentric navigation task. While appeared randomly active during free exploration, two groups emerged training five-arm star maze, distinguished by their peak activity. largest group was...