A5066345371- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- MRI in cancer diagnosis
- Genetic Associations and Epidemiology
- Multiple Sclerosis Research Studies
- Dementia and Cognitive Impairment Research
- Fetal and Pediatric Neurological Disorders
- Alzheimer's disease research and treatments
- Health, Environment, Cognitive Aging
- Epigenetics and DNA Methylation
- Medical Image Segmentation Techniques
- Radiomics and Machine Learning in Medical Imaging
- Systemic Lupus Erythematosus Research
- Ultrasound Imaging and Elastography
- Brain Tumor Detection and Classification
- Generative Adversarial Networks and Image Synthesis
- Bioinformatics and Genomic Networks
- Neurological Disease Mechanisms and Treatments
- Bone and Joint Diseases
- Pain Mechanisms and Treatments
- Acute Ischemic Stroke Management
- RNA regulation and disease
- Birth, Development, and Health
- Musculoskeletal pain and rehabilitation
University of Southern California
2018-2025
Southern California University for Professional Studies
2020-2025
Imaging Center
2020-2024
Viterbo University
2024
University of California, San Francisco
2014-2023
Brown University
2017
Women & Infants Hospital of Rhode Island
2017
University of California, Berkeley
2017
To characterize the accrual of long-term disability in a cohort actively treated multiple sclerosis (MS) patients and to assess whether clinical magnetic resonance imaging (MRI) data used trials have prognostic value.This is prospective study 517 managed MS enrolled at single center.More than 91% were retained, with ascertained up 10 years after baseline visit. At this last assessment, neurologic as measured by Expanded Disability Status Scale (EDSS) was stable or improved compared 41%...
Objective Rates of worsening and evolution to secondary progressive multiple sclerosis (MS) may be substantially lower in actively treated patients compared natural history studies from the pretreatment era. Nonetheless, our recently reported prospective cohort, more than half with relapsing MS accumulated significant new disability by 10th year follow‐up. Notably, “no evidence disease activity” at 2 years did not predict long‐term stability. Here, we determined what extent clinical relapses...
Alterations in white matter (WM) microstructure have been implicated the pathophysiology of major depressive disorder (MDD). However, previous findings inconsistent, partially due to low statistical power and heterogeneity depression. In largest multi-site study date, we examined WM anisotropy diffusivity 1305 MDD patients 1602 healthy controls (age range 12–88 years) from 20 samples worldwide, which included both adults adolescents, within Working Group Enhancing Neuroimaging Genetics...
The epilepsies are commonly accompanied by widespread abnormalities in cerebral white matter. ENIGMA-Epilepsy is a large quantitative brain imaging consortium, aggregating data to investigate patterns of neuroimaging common epilepsy syndromes, including temporal lobe epilepsy, extratemporal and genetic generalized epilepsy. Our goal was rank the most robust matter microstructural differences across within syndromes multicentre sample adult patients. Diffusion-weighted MRI were analysed from...
In multiple sclerosis (MS), cerebral gray matter (GM) atrophy correlates more strongly than white (WM) with disability. The corresponding relationships in the spinal cord (SC) are unknown due to technical limitations assessing SC GM atrophy. Using phase-sensitive inversion recovery (PSIR) magnetic resonance imaging, we determined association of and WM areas MS disability disease type.A total 113 patients 20 healthy controls were examined at 3T a PSIR sequence acquired C2/C3 disk level. Two...
An important image processing step in spinal cord magnetic resonance imaging is the ability to reliably and accurately segment grey white matter for tissue specific analysis. There are several semi- or fully-automated segmentation methods cervical cross-sectional area measurement with an excellent performance close equal manual segmentation. However, still challenging due small size shape, active research being conducted by groups around world this field. Therefore a challenge was organised...
MR imaging can be used to measure structural changes in the brains of individuals with multiple sclerosis and is essential for diagnosis, longitudinal monitoring, therapy evaluation. The North American Imaging Multiple Sclerosis Cooperative steering committee developed a uniform high-resolution 3T protocol relevant quantification cerebral lesions atrophy implemented it at 7 sites across United States. To assess intersite variability scan data, we imaged volunteer relapsing-remitting MS...
Objective A major challenge in multiple sclerosis (MS) research is the understanding of silent progression and Progressive MS. Using a novel method to accurately capture upper cervical cord area from legacy brain MRI scans we aimed study role spinal atrophy for conversion secondary progressive disease (SPMS). Methods From single‐center observational study, all RRMS (n = 360) SPMS 47) patients 80 matched controls were evaluated. patient subsets who converted 54) or silently progressed 159),...
A comprehensive characterization of the brain's white matter is critical for improving our understanding healthy and diseased aging. Here we used diffusion-weighted magnetic resonance imaging (dMRI) to estimate age sex effects on microstructure in a cross-sectional sample 15,628 adults aged 45-80 years old (47.6% male, 52.4% female). Microstructure was assessed using following four models: conventional single-shell model, diffusion tensor (DTI); more advanced distribution function (TDF); an...
Myelin repair is an unrealized therapeutic goal in the treatment of multiple sclerosis (MS). Uncertainty remains about optimal techniques for assessing efficacy and imaging biomarkers are required to measure corroborate myelin restoration. We analyzed water fraction from ReBUILD, a double-blind, randomized placebo-controlled (delayed treatment) remyelination trial, that showed significant reduction VEP latency patients with MS. focused on brain regions rich myelin. Fifty MS subjects two arms...
Age-related white matter (WM) microstructure maturation and decline occur throughout the human lifespan with a unique trajectory in brain, complementing process of gray development degeneration. Normative modeling can establish reference curves for typical WM microstructural aging patterns by pooling data from many independent studies that span different age ranges. Here, we create such harmonizing diffusion MRI (dMRI)-derived ten public datasets (N = 40,898 subjects; age: 3-95 years; 47.6%...
IMPORTANCEIn multiple sclerosis (MS), upper cervical cord gray matter (GM) atrophy correlates more strongly with disability than does brain or white (WM) atrophy.The corresponding relationships in the thoracic are unknown owing to technical difficulties assessing GM and WM compartments by conventional magnetic resonance imaging techniques.OBJECTIVES To investigate associations between MS disease type lower areas using phase-sensitive inversion recovery at 3 T, as well compare these those...
Although multiple HLA alleles associated with sclerosis (MS) risk have been identified, genotype-phenotype studies in the region remain scarce and inconclusive.To investigate whether MS risk-associated also affect disease phenotypes.A cross-sectional, case-control study comprising 652 patients who had comprehensive phenotypic information 455 individuals of European origin serving as controls was conducted at a single academic research site. Patients evaluated Multiple Sclerosis Center...
Abstract Recent work within neuroimaging consortia have aimed to identify reproducible, and often subtle, brain signatures of psychiatric or neurological conditions. To allow for high‐powered imaging analyses, it is necessary pool MR images that were acquired with different protocols across multiple scanners. Current retrospective harmonization techniques shown promise in removing site‐related image variation. However, most statistical approaches may over‐correct technical, scanning‐related,...
The source of inter-subject variability and the influence age gender on morphometric characteristics spinal cord, such as total cross-sectional area (TCA), gray matter (GM) white (WM) areas, currently remain under investigation. Understanding effect covariates age, gender, brain volumes, skull- vertebra-derived metrics cervical thoracic cord TCA GM areas in healthy subjects would be fundamental for exploring compartment specific changes neurological diseases affecting cord. Using Magnetic...
ABSTRACT PURPOSE Neurite orientation dispersion and density imaging (NODDI) has recently been developed to overcome diffusion technique limitations in modeling biological systems. This manuscript reports a preliminary investigation into the use of single color‐coded map represent NODDI‐derived information. MATERIALS AND METHODS An optimized diffusion‐weighted protocol was acquired several clinical neurological contexts including demyelinating disease, neoplastic process, stroke,...
<h3>Objective</h3> To determine if ovarian aging as measured by levels of anti-Müllerian hormone (AMH) is associated with pattern multiple sclerosis (MS) progression in women. <h3>Methods</h3> Women MS and healthy controls were included from a longitudinal research cohort up to 10 years follow-up. Plasma AMH ELISA for baseline 3, 5, 8–10. Mixed effects logistic linear regression models employed, adjustments age, disease duration, other covariables appropriate. <h3>Results</h3> similar...
Sleep spindles promote the consolidation of motor skill memory in young adults. Older adults, however, exhibit impoverished sleep-dependent consolidation. The underlying pathophysiological mechanism(s) explaining why older adults fails to benefit from sleep remains unclear. Here, we demonstrate that male and female show overnight relative with extent impairment being associated degree reduced frontal fast spindle density. magnitude loss was predicted by white matter integrity throughout...
Automatic neuroimaging processing tools provide convenient and systematic methods for extracting features from brain magnetic resonance imaging scans. One tool, FreeSurfer, provides an easy-to-use pipeline to extract cortical subcortical morphometric measures. There have been over 25 stable releases of with different versions used across published works. The reliability compatibility regional metrics derived the most recent version yet be empirically assessed. Here, we test-retest data three...
A concern for researchers planning multisite studies is that scanner and T1-weighted sequence-related biases on regional volumes could overshadow true effects, especially with a heterogeneous set of scanners sequences. Current approaches attempt to harmonize data by standardizing hardware, pulse sequences, protocols, or calibrating across sites using phantom-based corrections ensure the same raw image intensities. We propose avoid harmonization correction entirely. hypothesized bias...