Nico Papinutto
A5072658567- Advanced Neuroimaging Techniques and Applications
- Multiple Sclerosis Research Studies
- Advanced MRI Techniques and Applications
- Ultrasound Imaging and Elastography
- Functional Brain Connectivity Studies
- Medical Imaging and Analysis
- Peripheral Neuropathies and Disorders
- MRI in cancer diagnosis
- Systemic Lupus Erythematosus Research
- Fetal and Pediatric Neurological Disorders
- Cervical and Thoracic Myelopathy
- Ultrasound and Hyperthermia Applications
- Spinal Dysraphism and Malformations
- Radiomics and Machine Learning in Medical Imaging
- Herpesvirus Infections and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Systemic Sclerosis and Related Diseases
- Bone and Joint Diseases
- Medical Imaging Techniques and Applications
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Rheumatoid Arthritis Research and Therapies
- Prion Diseases and Protein Misfolding
- Brain Tumor Detection and Classification
- Neurobiology of Language and Bilingualism
- Cerebral Venous Sinus Thrombosis
University of California, San Francisco
2016-2025
Johns Hopkins University
2022-2024
National Institute of Mental Health
2024
National Institutes of Health
2024
National Institute of Neurological Disorders and Stroke
2024
University of Pennsylvania
2024
Center for Neurosciences
2020-2022
University of California, San Diego
2022
University of Maryland, Baltimore
2022
University of Maryland, College Park
2022
To characterize the accrual of long-term disability in a cohort actively treated multiple sclerosis (MS) patients and to assess whether clinical magnetic resonance imaging (MRI) data used trials have prognostic value.This is prospective study 517 managed MS enrolled at single center.More than 91% were retained, with ascertained up 10 years after baseline visit. At this last assessment, neurologic as measured by Expanded Disability Status Scale (EDSS) was stable or improved compared 41%...
Objective Rates of worsening and evolution to secondary progressive multiple sclerosis (MS) may be substantially lower in actively treated patients compared natural history studies from the pretreatment era. Nonetheless, our recently reported prospective cohort, more than half with relapsing MS accumulated significant new disability by 10th year follow‐up. Notably, “no evidence disease activity” at 2 years did not predict long‐term stability. Here, we determined what extent clinical relapses...
In multiple sclerosis (MS), cerebral gray matter (GM) atrophy correlates more strongly than white (WM) with disability. The corresponding relationships in the spinal cord (SC) are unknown due to technical limitations assessing SC GM atrophy. Using phase-sensitive inversion recovery (PSIR) magnetic resonance imaging, we determined association of and WM areas MS disability disease type.A total 113 patients 20 healthy controls were examined at 3T a PSIR sequence acquired C2/C3 disk level. Two...
An important image processing step in spinal cord magnetic resonance imaging is the ability to reliably and accurately segment grey white matter for tissue specific analysis. There are several semi- or fully-automated segmentation methods cervical cross-sectional area measurement with an excellent performance close equal manual segmentation. However, still challenging due small size shape, active research being conducted by groups around world this field. Therefore a challenge was organised...
OBJECT Diffusion MRI has uniquely enabled in vivo delineation of white matter tracts, which been applied to the segmentation eloquent pathways for intraoperative mapping. The last decade also seen development from earlier diffusion tensor models higher-order models, take advantage high angular resolution diffusion-weighted imaging (HARDI) techniques. However, these advanced methods have not widely implemented routine preoperative and authors report on application residual bootstrap q-ball...
MR imaging can be used to measure structural changes in the brains of individuals with multiple sclerosis and is essential for diagnosis, longitudinal monitoring, therapy evaluation. The North American Imaging Multiple Sclerosis Cooperative steering committee developed a uniform high-resolution 3T protocol relevant quantification cerebral lesions atrophy implemented it at 7 sites across United States. To assess intersite variability scan data, we imaged volunteer relapsing-remitting MS...
Objective A major challenge in multiple sclerosis (MS) research is the understanding of silent progression and Progressive MS. Using a novel method to accurately capture upper cervical cord area from legacy brain MRI scans we aimed study role spinal atrophy for conversion secondary progressive disease (SPMS). Methods From single‐center observational study, all RRMS (n = 360) SPMS 47) patients 80 matched controls were evaluated. patient subsets who converted 54) or silently progressed 159),...
Polygenic inheritance plays a pivotal role in driving multiple sclerosis susceptibility, an inflammatory demyelinating disease of the CNS. We developed polygenic risk scores (PRS) and assessed associations with both status severity cohorts European descent. The largest genome-wide association dataset for to date (n = 41 505) was leveraged generate PRS scores, serving as informative susceptibility marker, tested two independent datasets, UK Biobank [area under curve (AUC) 0.73, 95% confidence...
Myelin repair is an unrealized therapeutic goal in the treatment of multiple sclerosis (MS). Uncertainty remains about optimal techniques for assessing efficacy and imaging biomarkers are required to measure corroborate myelin restoration. We analyzed water fraction from ReBUILD, a double-blind, randomized placebo-controlled (delayed treatment) remyelination trial, that showed significant reduction VEP latency patients with MS. focused on brain regions rich myelin. Fifty MS subjects two arms...
While neurodegeneration underlies the pathological basis for permanent disability in multiple sclerosis (MS), predictive biomarkers progression are lacking. Using an animal model of chronic MS, we find that synaptic injury precedes neuronal loss and identify thinning inner plexiform layer (IPL) as early feature inflammatory demyelination—prior to symptom onset. As domains anatomically segregated retina can be monitored longitudinally, hypothesize IPL could represent a biomarker MS....
The inferior fronto-occipital fasciculus (IFOF) is historically described as the longest associative bundle in human brain and it connects various parts of occipital cortex, temporo-basal area superior parietal lobule to frontal lobe through external/extreme capsule complex. exact functional role detailed anatomical definition IFOF are still under debate within scientific community. In this study we present a fiber tracking dissection right left by using q-ball residual-bootstrap...
IMPORTANCEIn multiple sclerosis (MS), upper cervical cord gray matter (GM) atrophy correlates more strongly with disability than does brain or white (WM) atrophy.The corresponding relationships in the thoracic are unknown owing to technical difficulties assessing GM and WM compartments by conventional magnetic resonance imaging techniques.OBJECTIVES To investigate associations between MS disease type lower areas using phase-sensitive inversion recovery at 3 T, as well compare these those...
The anterior temporal lobes (ATL) have been implicated in a range of cognitive functions including auditory and visual perception, language, semantic knowledge, social-emotional processing. However, the anatomical relationships between ATLs broader cortical networks that subserve these not fully elucidated. Using diffusion tensor imaging (DTI) probabilistic tractography, we tested hypothesis functional segregation information is reflected by distinct patterns structural connectivity to...
Abstract In a companion paper by Cohen-Adad et al . we introduce the spine generic quantitative MRI protocol that provides valuable metrics for assessing spinal cord macrostructural and microstructural integrity. This was used to acquire single subject dataset across 19 centers multi-subject 42 (for total of 260 participants), spanning three main manufacturers: GE, Philips Siemens. Both datasets are publicly available via git-annex. Data were analysed using Spinal Cord Toolbox produce...
The source of inter-subject variability and the influence age gender on morphometric characteristics spinal cord, such as total cross-sectional area (TCA), gray matter (GM) white (WM) areas, currently remain under investigation. Understanding effect covariates age, gender, brain volumes, skull- vertebra-derived metrics cervical thoracic cord TCA GM areas in healthy subjects would be fundamental for exploring compartment specific changes neurological diseases affecting cord. Using Magnetic...
ABSTRACT PURPOSE Neurite orientation dispersion and density imaging (NODDI) has recently been developed to overcome diffusion technique limitations in modeling biological systems. This manuscript reports a preliminary investigation into the use of single color‐coded map represent NODDI‐derived information. MATERIALS AND METHODS An optimized diffusion‐weighted protocol was acquired several clinical neurological contexts including demyelinating disease, neoplastic process, stroke,...
<h3>Objective</h3> To determine if ovarian aging as measured by levels of anti-Müllerian hormone (AMH) is associated with pattern multiple sclerosis (MS) progression in women. <h3>Methods</h3> Women MS and healthy controls were included from a longitudinal research cohort up to 10 years follow-up. Plasma AMH ELISA for baseline 3, 5, 8–10. Mixed effects logistic linear regression models employed, adjustments age, disease duration, other covariables appropriate. <h3>Results</h3> similar...
Adrenomyeloneuropathy is the late-onset form of X-linked adrenoleukodystrophy, and considered most frequent metabolic hereditary spastic paraplegia. In adrenomyeloneuropathy spinal cord main site pathology. Differently from quantitative magnetic resonance imaging brain, little known about feasibility utility advanced neuroimaging in quantifying abnormalities diseases. Moreover, subtle pathological changes that can characterize brain subjects early stages disease. We performed a...
The semantic variant of primary progressive aphasia (svPPA) is a clinical syndrome characterized by memory deficits with relatively preserved motor speech, syntax, and phonology. There consistent evidence linking focal neurodegeneration the anterior temporal lobes (ATL) to observed in svPPA. Less known about large-scale functional connectivity changes this syndrome, particularly regarding interplay between affected spared language networks that leads unique cognitive dissociations typical...
In multisite neuroimaging studies there is often unwanted technical variation across scanners and sites. These "scanner effects" can hinder detection of biological features interest, produce inconsistent results, lead to spurious associations. We propose mica (multisite image harmonization by cumulative distribution function alignment), a tool harmonize images taken on different identifying removing within-subject scanner effects. Our goals in the present study were (1) establish method that...
Background: Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) and pediatric-onset multiple sclerosis (POMS) share clinical magnetic resonance imaging (MRI) features but differ in prognosis management. Early POMS diagnosis is essential to avoid disability accumulation. Central vein sign (CVS), paramagnetic rim lesions (PRLs), central core (CCLs) are susceptibility-based (SbI)-related signs understudied pediatric populations that may help discerning from MOGAD....
ABSTRACT Background and Purpose The central vein sign (CVS) is a diagnostic imaging biomarker for multiple sclerosis (MS). FLAIR* combined MRI contrast that provides high conspicuity CVS at 3 Tesla (3T), enabling its sensitive accurate detection in clinical settings. This study evaluated whether of 3T reliable across sites vendors gadolinium (Gd) increases conspicuity. Methods A cross‐sectional, multicenter recruited adults referred possible diagnosis MS 10 sites. was generated using...
Sporadic Creutzfeldt-Jakob disease is considered primarily a of grey matter, although the extent white matter involvement has not been well described. We used diffusion tensor imaging to study in sporadic compared healthy control subjects and correlated magnetic resonance findings with histopathology. Twenty-six patients nine age- gender-matched underwent volumetric T1-weighted imaging. Six had post-mortem brain analysis available for assessment neuropathological associated prion disease....
A concern for researchers planning multisite studies is that scanner and T1-weighted sequence-related biases on regional volumes could overshadow true effects, especially with a heterogeneous set of scanners sequences. Current approaches attempt to harmonize data by standardizing hardware, pulse sequences, protocols, or calibrating across sites using phantom-based corrections ensure the same raw image intensities. We propose avoid harmonization correction entirely. hypothesized bias...