A5010761420- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Genetic Neurodegenerative Diseases
- Acute Lymphoblastic Leukemia research
- Ultrasound and Hyperthermia Applications
- Neurological disorders and treatments
- Mitochondrial Function and Pathology
- Advanced Neuroimaging Techniques and Applications
- RNA regulation and disease
- Systemic Sclerosis and Related Diseases
- Systemic Lupus Erythematosus Research
- Neurogenesis and neuroplasticity mechanisms
- Advanced MRI Techniques and Applications
- Health Systems, Economic Evaluations, Quality of Life
- Herpesvirus Infections and Treatments
- Bioinformatics and Genomic Networks
- Functional Brain Connectivity Studies
- Polyomavirus and related diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA Research and Splicing
- Botulinum Toxin and Related Neurological Disorders
- Cancer Treatment and Pharmacology
- Powdery Mildew Fungal Diseases
- Prion Diseases and Protein Misfolding
- Rheumatoid Arthritis Research and Therapies
The University of Texas at Austin
2018-2025
Johns Hopkins University
2019-2024
National Institute of Mental Health
2024
National Institutes of Health
2024
National Institute of Neurological Disorders and Stroke
2024
University of Pennsylvania
2024
Multiple Sclerosis Center of Atlanta
2022
The University of Texas Health Science Center at Houston
2014-2021
Houston Methodist
2021
Cornell University
2021
Quantitative in vivo imaging of myelin loss and repair patients with multiple sclerosis (MS) is essential to understand the pathogenesis disease evaluate promyelinating therapies. Selectively binding central nervous system white matter, Pittsburgh compound B ([11 C]PiB) can be used as a positron emission tomography (PET) tracer explore dynamics MS.Patients active relapsing-remitting MS (n = 20) healthy controls 8) were included longitudinal trial combining PET [11 C]PiB magnetic resonance...
Abstract Objective: Imaging of myelin tracts in vivo would greatly improve the monitoring demyelinating diseases such as multiple sclerosis (MS). To date, no imaging technique specifically targets demyelination and remyelination. Recently, amyloid markers related to Congo red have been shown bind central nervous system (CNS) myelin. Here we questioned whether thioflavine‐T derivative 2‐(4′‐methylaminophenyl)‐6‐hydroxybenzothiazole (PIB), which also binds plaques, could serve a marker....
Abstract Severe cognitive impairment involving multiple domains can occur early during the course of sclerosis (MS). We investigated resting state functional connectivity changes in large‐scale brain networks and related structural damage underlying dysfunction patients with MS. Patients relapsing MS (3–5 years disease duration) were prospectively assigned to two groups based on a standardized neuropsychological evaluation: (1) cognitively impaired group (CI group, n = 15), abnormal...
<h3>Objective</h3> To define the role played by microglia in different stages of Huntington disease (HD), we used TSPO radioligand [11C]-ER176 and PET to evaluate microglial activation relation neurodegeneration clinical features seen at premanifest manifest disease. <h3>Methods</h3> This is a cross-sectional study which 18 subjects (6 controls, 6 premanifest, HD gene carriers) underwent scan an MRI for anatomic localization. Segmentation regions interest (ROIs) was performed, group...
<h3>Importance</h3> Huntington disease (HD), a prototypic monogenic disease, is caused by an expanded CAG repeat in the<i>HTT</i>gene exceeding 35 units. However, not all patients with HD phenotype carry the pathological expansion in<i>HTT</i>, and positive diagnosis rate poor. <h3>Objectives</h3> To examine phenotypes to determine frequency of phenocopies typical features but without expansions in<i>HTT</i>in attempt improve rate. <h3>Design, Setting, Participants</h3> Between January 1,...
The specificity and implementation of current MRI-based diagnostic criteria for multiple sclerosis (MS) are imperfect. Approximately 1 in 5 individuals diagnosed with MS eventually determined not to have the disease, overreliance on MRI findings a major cause misdiagnosis. central vein sign (CVS), proposed biomarker lesions, has been extensively studied numerous cross sectional studies may increase MS. CVS desirable analytical, measurement, scalability properties. "Central Vein Sign: A...
ABSTRACT Background and Purpose The central vein sign (CVS) is a diagnostic imaging biomarker for multiple sclerosis (MS). FLAIR* combined MRI contrast that provides high conspicuity CVS at 3 Tesla (3T), enabling its sensitive accurate detection in clinical settings. This study evaluated whether of 3T reliable across sites vendors gadolinium (Gd) increases conspicuity. Methods A cross‐sectional, multicenter recruited adults referred possible diagnosis MS 10 sites. was generated using...
Objective Using positron emission tomography (PET) with [ 11 C]flumazenil ([ C]FMZ), an antagonist of the central benzodiazepine site located within GABA A receptor, we quantified and mapped neuronal damage in gray matter (GM) patients multiple sclerosis (MS) at distinct disease stages. We investigated relationship between white (WM) lesions evaluated clinical relevance this PET metric. Methods cohort 18 MS (9 progressive 9 relapsing‐remitting) was compared to healthy controls underwent...
Background: The central vein sign (CVS) is a proposed magnetic resonance imaging (MRI) biomarker for multiple sclerosis (MS); the optimal method abbreviated CVS scoring not yet established. Objective: aim of this study was to evaluate performance simplified approach assessment in multicenter patients being evaluated suspected MS. Methods: Adults referred possible MS 10 sites were recruited. A post-Gd 3D T2*-weighted MRI sequence (FLAIR*) obtained each subject. Trained raters at site...
This study aimed to determine whether choroid plexus volume (CPV) could differentiate multiple sclerosis (MS) from its mimics. A secondary analysis of two previously enrolled studies, 50 participants with MS and 64 alternative diagnoses were included. CPV was automatically segmented 3T magnetic resonance imaging (MRI), followed by manual review remove misclassified tissue. Mean normalized (nCPV) intracranial demonstrated relatively high specificity for in each cohort (0.80 0.76) an area...
Real-world studies of disease-modifying therapies (DMTs) in multiple sclerosis (MS) have reported suboptimal adherence.We aimed to describe treatment patterns, relapses, healthcare resource utilization, and costs MS patients experiencing their first observed DMT switch.In this retrospective, claims database study, adult were selected if they had an diagnosis claim during the study period (1 January 2009-31 March 2019). Patients who switched a new between 1 2010 31 2018 included. Adherence,...
Global and regional cortical thicknesses based on T1-weighted magnetic resonance images acquired at 1.5 T 3 were measured a relatively large cohort of 295 subjects using FreeSurfer software. Multivariate regression analysis was performed Pillai's trace test to determine significant differences in these two field strengths. Our results indicate that global thickness is not affected by the strength or gender. In contrast, observed be dependent. Specifically, regions such as parahippocampal,...
Cerebrospinal fluid (CSF) oligoclonal bands (OCB) are a diagnostic biomarker in multiple sclerosis (MS). The central vein sign (CVS) is an imaging for MS that may improve accuracy.
Abstract Background: Responsive ataxia rating scales are essential for determining outcome measures in clinical trials. Methods: We evaluated the responsiveness over time of composite cerebellar functional severity score, a quantitative score measuring 133 patients with autosomal dominant ataxias (ADCA), which were prospectively at inclusion and after one‐year follow‐up. A more responsive tool was developed, Cerebellar Functional Severity writing, incorporating writing test hand to score....
Multiple sclerosis (MS) is a complex disease in which the immune system attacks central nervous system. The molecular mechanisms contributing to etiology of MS remain poorly understood. Genome-wide association studies (GWAS) have identified small number genetic loci significant at genome level, but they are mainly non-coding variants. Network-assisted analysis may help better interpret functional roles variants with signals and potential translational medicine application. Dense Module...
The central vein sign (CVS) is a proposed MRI biomarker of multiple sclerosis (MS). impact gadolinium-based contrast agent (GBCA) administration on CVS evaluation remains poorly investigated.
The striatum is a well‐known region affected in Huntington disease (HD). However, other regions, including the visual cortex, are implicated. We have identified previously an abnormal energy response cortex of patients at early stage HD using 31 P magnetic resonance spectroscopy ( MRS). therefore sought to further characterize these metabolic alterations with 1 H MRS well‐validated semi‐localized by adiabatic selective refocusing (semi‐LASER) sequence that allows measurement expanded number...
Early diagnosis and treatment of multiple sclerosis (MS) with disease-modifying therapy (DMT) can reduce relapse number severity, which has cost implications. We describe patterns, healthcare utilization, among MS patients newly initiating DMTs (index).DMT-naïve adults 12 months' continuous enrollment pre- post-index ≥2 claims (2009‒2018) were identified from the Optum Clinformatics Data Mart database. Treatment adherence persistence measured as time on index DMT. Relapses using a validated...
Multiple sclerosis (MS) is a complex dysimmune disorder of the central nervous system. Genome-wide association studies (GWAS) have identified 233 genetic variations associated with MS at genome-wide significant level. Epigenetic pinpointed differentially methylated CpG sites in patients. However, interplay between risk factors and epigenetic regulation remains elusive. Here, we employed network model to integrate GWAS summary statistics 14 802 cases 26 703 controls DNA methylation profiles...