A5035116666- Multiple Sclerosis Research Studies
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Peripheral Neuropathies and Disorders
- Polyomavirus and related diseases
- Systemic Sclerosis and Related Diseases
- Immune Cell Function and Interaction
- Systemic Lupus Erythematosus Research
- Cerebral Venous Sinus Thrombosis
- Monoclonal and Polyclonal Antibodies Research
- Herpesvirus Infections and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Noise Effects and Management
- Viral-associated cancers and disorders
- Rheumatoid Arthritis Research and Therapies
- Cerebrovascular and genetic disorders
- Immunodeficiency and Autoimmune Disorders
- Sexual function and dysfunction studies
- Cytokine Signaling Pathways and Interactions
- CAR-T cell therapy research
- Gut microbiota and health
- T-cell and Retrovirus Studies
- Vestibular and auditory disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Trigeminal Neuralgia and Treatments
The University of Texas Health Science Center at Houston
2013-2024
University of California, San Francisco
2024
Faculty of 1000 (United States)
2023
Baylor College of Medicine
2023
Texas Neurology
2020
The University of Texas at Austin
2008-2019
In-Q-Tel
2015
Naval Medical Research Command
1998
Wright-Patterson Air Force Base
1998
University of Alabama at Birmingham
1997
The gut microbiome plays an important role in immune function and has been implicated multiple sclerosis (MS). However, how if the modulation of microbiota can prevent or treat MS remain largely unknown. In this study, we showed that probiotic Lactobacillus reuteri DSM 17938 (L. reuteri) ameliorated development murine experimental autoimmune encephalomyelitis (EAE), a widely used animal model MS, which is primarily mediated by TH17 TH1 cells. We discovered L. treatment reduced TH1/TH17 cells...
The ongoing US Glatiramer Acetate (GA) Trial is the longest evaluation of continuous immunomodulatory therapy in relapsing—remitting multiple sclerosis (RRMS). objective this study was to evaluate up 15 years GA as a sole disease-modifying therapy. Two hundred and thirty-two patients received at least one dose since initiation 1991 (mITT cohort), 100 (43%, Ongoing cohort) continued February 2008. Patients were evaluated every 6 months using Expanded Disability Status Scale (EDSS). Mean...
Abstract Development of an immune or autoimmune response involves T-cell activation in lymphoid organs and subsequent migration to peripheral tissues. Here we show that T-cell-specific ablation the kinase TBK1 promotes but causes retention effector T cells draining lymph node a neuroinflammatory autoimmunity model, experimental encephalomyelitis (EAE). At older ages, T-cell-conditional TBK1-knockout mice also spontaneously accumulate with activated phenotype. controls AKT its downstream...
Epstein-Barr virus (EBV) infection has long been associated with multiple sclerosis (MS), but the role of EBV in pathogenesis MS is not clear. Our hypothesis that a major fraction expanded clones T lymphocytes cerebrospinal fluid (CSF) are specific for autologous EBV-infected B cells. We obtained blood and CSF samples from eight relapsing-remitting patients process diagnosis. stimulated cells lymphoblastoid cell lines (LCL), EBV, varicella zoster virus, influenza, candida sorted responding...
Abstract We treated 21 multiple sclerosis patients with two to four doses of cM‐T412, a chimeric monoclonal antibody against the CD4 antigen found on helper/inducer T lymphocytes. The mean number (± standard error) circulating lymphocytes decreased from 888 81) cells/mm 3 at baseline 246 18) after treatment. At 1 year last treatment, count had recovered only 335 32). no effect CD8 lymphocytes, B or other leukocytes. Side effects were minimal. Despite prolonged depletion opportunistic...
Six patients with severe postural cerebellar tremor were studied in a double-blind, placebo-controlled, crossover trial isoniazid. Each phase of the study lasted 4 weeks, and isoniazid received an increasing dose up to 1200 mg/d. Patients self-rating scales, quantitative recording, blinded ratings videotapes. All improved by at least one method, three all methods, four sufficiently want continue drug after was finished. There is definite, but limited, therapeutic role for
Background Epstein–Barr virus (EBV) is associated with MS, but it not clear whether EBV plays a role in the pathogenesis of MS. Hypothesis We hypothesized that immune control might be defective and reactivation drive response Methods collected blood from controls patients measured amounts DNA RNA using quantitative PCR. Results found were frequently detectable peripheral leukocytes both MS normal controls. There was no significant difference between or Paired samples small number subjects...
Background: In Phase 3 double-blind trials (MS-F203 and MS-F204), dalfampridine extended release tablets 10 mg twice daily (dalfampridine-ER; prolonged-release fampridine in Europe; modified or sustained elsewhere) improved walking speed relative to placebo patients with multiple sclerosis (MS). Objectives: Evaluation of long-term safety efficacy dalfampridine-ER open-label extensions (MS-F203EXT, MS-F204EXT). Methods: Patients received daily; had Timed 25-Foot Walk (T25FW) assessments at 2,...
Spasticity is a serious problem in multiple sclerosis (MS) and many patients do not achieve satisfactory response to currently available oral antispasticity drugs. Tizanidine hydrochloride, an alpha 2-noradrenergic agonist, has been shown have effect single center trials of with MS.To compare plasma concentrations tizanidine objective measures muscle tone MS moderate severe spasticity.Ten centers, all tertiary referral centers for the specialized treatment MS, United States Canada.A...
Chronic cerebrospinal venous insufficiency (CCSVI) has been implicated in the pathophysiology of multiple sclerosis (MS). We sought to determine whether neurosonography (NS) provides reliable information on cerebral outflow patterns specific MS.This was a single-center, prospective case-control study volunteer MS and non-MS participants. A neurosonologist, blind subjects' diagnosis, used high-resolution B-mode imaging with color spectral Doppler systematically investigate, capture, record...
The repertoire of TCR V beta genes transcribed and expressed within the central nervous system was determined in mice with experimental allergic encephalomyelitis. Disease induced (PL/J x SJL/)F1 by immunizing myelin basic protein-acetylated peptide 1-11, were sacrificed at intervals from day 3 postimmunization to wk after recovery disease. Transcription reverse transcriptase polymerase chain reaction on RNA extracted spinal cord, expression gene products detected immunohistochemistry mAb...
We conducted an open trial of cM-T412, a chimeric monoclonal anti-CD4 antibody, in 29 patients with MS. This antibody caused prompt and long-lasting depletion circulating CD4 (helper/inducer) lymphocytes. The mean (±SE) count for the group decreased from 870 (±66) cells/mm<sup>3</sup> at baseline to 76 (±11) 3 hours after treatment, then increased 425 (±38) 1 month treatment 475 (±39) 6 months treatment. Numbers CD8 (cytotoxic/suppressor) lymphocytes, B granulocytes, monocytes changed...
Background: Our objective was to determine whether antibodies against the Epstein–Barr virus (EBV) nuclear antigen‐1 (EBNA‐1), early antigen (EA), and EBV neutralizing (NeutAb) are altered in multiple sclerosis (MS). Methods: We measured EBNA‐1 IgG, EA IgA using quantitative ELISA. NeutAb a competitive studied 80 patients with MS, matched controls, 19 MS samples collected both whilst stable relapse. Results: IgG were increased compared controls. The index value 23.3 ± 18.3 (mean SD) 16.3...
Large demyelinating lesions with possible mass effect (tumefactive multiple sclerosis or tumefactive demyelination) can be mistaken for tumour-like space-occupying suggesting a malignant outcome.We reviewed our own experience of subjects (n = 28) demyelination to determine the relationship between clinical outcomes and lesion evolution, their different therapies. Patients central nervous system disease were identified from database over last 10 years.No patient increased in extended...
We sought to determine whether combinations of glatiramer acetate and parenteral or ingested type I interferon were synergistic in experimental autoimmune encephalomyelitis. Glatiramer acetate, subcutaneous murine interferon-alpha, interferon-alpha individually improved clinical scores. In contrast, conjunction with either did not improve scores compared control. These data suggest that trials designed test a possible effect humans should be detect adverse effects this combination...
The objective of this study was to determine whether reactivation Epstein-Barr (EBV) or activation the anti-EBV immune response correlates with MS disease activity on MR imaging.Subjects early, active relapsing-remitting were studied for 16 weeks blood and saliva samples collected every 2 brain MRI performed 4 weeks. We isolated peripheral mononuclear cells from each sample tested EBV, autologous EBV-infected lymphoblastoid cell lines (LCL), human herpesvirus 6 (HHV6), varicella zoster virus...