A5103080115- Cancer Immunotherapy and Biomarkers
- Cutaneous Melanoma Detection and Management
- Melanoma and MAPK Pathways
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Radiomics and Machine Learning in Medical Imaging
- Immune Cell Function and Interaction
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Head and Neck Cancer Studies
- Lung Cancer Research Studies
- NF-κB Signaling Pathways
- Advanced X-ray and CT Imaging
- interferon and immune responses
- Meat and Animal Product Quality
- T-cell and B-cell Immunology
- Spinal Fractures and Fixation Techniques
- Adipose Tissue and Metabolism
- Advanced MRI Techniques and Applications
- Cutaneous lymphoproliferative disorders research
- Virus-based gene therapy research
- Diet and metabolism studies
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
Institute of Subtropical Agriculture
2022-2025
University of Chinese Academy of Sciences
2020-2025
Ningbo University
2025
Chinese Academy of Sciences
2022-2024
Peking University
2005-2024
Peking University Cancer Hospital
2005-2024
Air Force General Hospital PLA
2024
First People's Hospital of Chongqing
2019-2024
Kunming Institute of Botany
2023
Shanghai Ocean University
2023
Chimeric antigen receptor (CAR)-engineered T cells have demonstrated promising clinical efficacy in patients with B cell lymphoma. However, the application of CAR-T therapy treatment other solid tumors has been limited. We incorporated 4-1BB into anti-GD2 to test their cytotoxicity melanoma vitro and vivo. Moreover, we reported expression ganglioside GD2 non-Caucasian populations for first time, thus providing a basis future research. This study included tumor samples from 288 at Peking...
JS001, a humanized IgG4 monoclonal antibody against the programmed death-1 (PD-1) receptor, blocks interaction of PD-1 with its ligands and promotes T cell activation in preclinical studies. This phase I study is designed to evaluate safety, tolerability, clinical activity JS001 advanced melanoma or urologic cancer patients who are refractory standard systemic therapy. In dose escalation cohorts, subjects initially received single-dose, intravenous infusion were followed for 28 days by...
Abstract Development of an immune or autoimmune response involves T-cell activation in lymphoid organs and subsequent migration to peripheral tissues. Here we show that T-cell-specific ablation the kinase TBK1 promotes but causes retention effector T cells draining lymph node a neuroinflammatory autoimmunity model, experimental encephalomyelitis (EAE). At older ages, T-cell-conditional TBK1-knockout mice also spontaneously accumulate with activated phenotype. controls AKT its downstream...
Purpose: Effective therapies for the majority of metastatic acral melanoma patients have not been established. Thus, we investigated genetic aberrations CDK4 pathway in and evaluated efficacy CDK4/6 inhibitors targeted therapy melanoma.Experimental Design: A total 514 primary samples were examined copy number variations (CNV) pathway-related genes, including Cdk4, Ccnd1, P16INK4a , by QuantiGenePlex DNA Assay. The sensitivity established cell lines patient-derived xenograft (PDX) containing...
PD-1 checkpoint blockade immunotherapy induces long and durable response in patients with advanced melanoma. However, only a subset of melanoma benefit from this approach. The mechanism triggering the innate resistance anti-PD-1 therapy remains unclear.Experimental Design: Whole-exome sequencing (WES) RNA (RNA-Seq) analyses were performed training cohort (n = 31) using baseline tumor biopsies treated antibody. Copy-number variations (CNVs) for genes CDK4, CCND1, CDKN2A assayed TaqMan...
Background The indoleamine 2,3-dioxygenase (IDO) pathway is a key counter-regulatory mechanism that, in cancer, exploited by tumors to evade antitumor immunity. Indoximod small-molecule IDO inhibitor that reverses the immunosuppressive effects of low tryptophan (Trp) and high kynurenine (Kyn) result from activity. In this study, indoximod was used combination with checkpoint (CPI) pembrolizumab for treatment advanced melanoma. Methods Patients melanoma were enrolled single-arm phase II...
Plant-microbe interactions are considered to be important processes determining the efficiency of phytoremediation petroleum pollution, however relatively little is known about how these influenced by pollution. In this experimental study using a microcosm approach, we examined plant ecophysiological traits, soil nutrients and microbial activities were pollution in Phragmites australis, phytoremediating species. Generally, reduced performance, especially at early stages growth. Petroleum had...
Background Melanoma in people of Asian descent presents primarily non-sun-exposed areas, such as acral and mucosal melanoma. Compared with the predominant sun-exposed area melanomas Caucasians, do not respond well to immunotherapy are associated a worse prognosis. Hence, there is an urgent need for improved treatment melanoma Asians. This phase Ib trial evaluated safety efficacy modified herpes simplex virus-1 oncolytic virus OrienX010 Chinese patients unresectable stage IIIC–IV Methods...
The tropane alkaloids (TAs) cocaine and hyoscyamine have been used medicinally for thousands of years. To understand the evolutionary origins trajectories serial biosynthetic enzymes TAs especially characteristic skeletons, we generated chromosome-level genome assemblies cocaine-producing Erythroxylum novogranatense (Erythroxylaceae, rosids clade) hyoscyamine-producing Anisodus acutangulus (Solanaceae, asterids clade). Comparative genomic phylogenetic analysis suggested that lack spermidine...
Abstract Objective To construct and validate a model based on the dual-energy computed tomography (DECT) quantitative parameters radiological features to predict Ki-67 expression levels in pancreatic ductal adenocarcinoma (PDAC). Materials methods Data from 143 PDAC patients were analysed. The variables of clinic, radiology DECT evaluated. In arterial phase portal venous (PVP), normalized iodine concentration (NIC), effective atomic number slope spectral attenuation curves measured....
Study Design. Retrospective cohort study. Objective. To illustrate the technique of modified transpedicular subtraction and disc osteotomy combined with long-segment fixation for treatment Kümmell disease neurologic deficits to evaluate clinical radiographic results patients treated technique. Summary Background Data. is a condition in which develop kyphosis lower thoracolumbar spinal region months years after sustaining an otherwise asymptomatic minor spinal. Currently, neurological...
This study aims to investigate the role of BRAF-activated long non-coding RNA (BANCR) in papillary thyroid carcinoma (PTC) progression and its association with clinical molecular characteristics. Sixteen PTC patients were stratified into four groups (PTC, HT, HT-LNM, PTC-LNM) based on cervical lymph node metastasis concurrent Hashimoto's thyroiditis (HT) explore BANCR expression relationship immune-related factors tumor microenvironment (TME). Functional assays, including Transwell invasion,...
The noncanonical NF-κB pathway induces processing of the NF-κB2 precursor protein p100, and thereby mediates activation p52-containing complexes. This is crucial for B cell maturation humoral immunity, but its role in regulating T function less clear. Using mutant mice that express a nonprocessible NF-κB2(lym1), we show has cell-intrinsic pathogenesis cell-mediated autoimmunity, experimental autoimmune encephalomyelitis (EAE). Although lym1 mutation does not interfere with naive activation,...
Abstract Mitogen activated protein kinase 18 (MAPKKK18) mediated signaling cascade plays important roles in Arabidopsis drought stress tolerance. However, the post‐translational modulation patterns of MAPKKK18 are not characterized. In this study, we found that level was tightly controlled by 26S proteasome. Ubiquitin ligases RGLG1 and RGLG2 ubiquitinated at lysine residue K32 K154, promoted its degradation. Deletion stabilized further enhanced tolerance ‐overexpression plants. Our data...
T-cell receptor–α (TCRα) rearrangement in CD4 + CD8 double-positive immature thymocytes is a prerequisite for production of αβ T cells and invariant natural killer cells. This developmental event regulated by the TCRα enhancer (Eα), which induces chromatin modification recruitment recombination-activating proteins Rag1 Rag2. However, molecular mechanism underlying activation long-range action Eα remains incompletely understood. We show here that chromatin-modifying factor TRIM28 highly...