A5100665866- RNA modifications and cancer
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Peptidase Inhibition and Analysis
- Acute Lymphoblastic Leukemia research
- Ovarian cancer diagnosis and treatment
- Chromatin Remodeling and Cancer
- Glioma Diagnosis and Treatment
- Protein Degradation and Inhibitors
- DNA Repair Mechanisms
- Histone Deacetylase Inhibitors Research
- Carcinogens and Genotoxicity Assessment
- Cancer, Lipids, and Metabolism
- Ubiquitin and proteasome pathways
- Transplantation: Methods and Outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer, Hypoxia, and Metabolism
- Genetics and Neurodevelopmental Disorders
- Cancer Immunotherapy and Biomarkers
- Neuroblastoma Research and Treatments
- Gastric Cancer Management and Outcomes
- Chemical Reactions and Isotopes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer Genomics and Diagnostics
Fudan University
2022-2025
University of California, Davis
2019-2025
Zhongshan Hospital
2022-2025
The First Affiliated Hospital, Sun Yat-sen University
2022-2025
Sun Yat-sen University
2021-2025
Tropical Crops Genetic Resources Institute
2025
Chinese Academy of Tropical Agricultural Sciences
2025
Hangzhou Cancer Hospital
2021-2025
Obstetrics and Gynecology Hospital of Fudan University
2025
West China Hospital of Sichuan University
2022-2025
The Hu5F9-G4 (hereafter, 5F9) antibody is a macrophage immune checkpoint inhibitor blocking CD47 that induces tumor-cell phagocytosis. 5F9 synergizes with rituximab to eliminate B-cell non-Hodgkin's lymphoma cells by enhancing macrophage-mediated antibody-dependent cellular This combination was evaluated clinically.
PURPOSE To evaluate the safety, pharmacokinetics, and pharmacodynamics of Hu5F9-G4 (5F9), a humanized IgG4 antibody that targets CD47 to enable phagocytosis. PATIENTS AND METHODS Adult patients with solid tumors were treated in four cohorts: part A, determine priming dose; B, weekly maintenance C, study loading dose week 2; tumor biopsy cohort. RESULTS Sixty-two treated: 11 14 22 15 Part A used doses ranged from 0.1 3 mg/kg. On basis tolerability receptor occupancy studies showed 100%...
Abstract Glioblastoma multiforme (GBM) remains the top challenge to radiotherapy with only 25% one-year survival after diagnosis. Here, we reveal that co-enhancement of mitochondrial fatty acid oxidation (FAO) enzymes (CPT1A, CPT2 and ACAD9) immune checkpoint CD47 is dominant in recurrent GBM patients poor prognosis. A glycolysis-to-FAO metabolic rewiring associated anti-phagocytosis radioresistant cells regrown radiation syngeneic mice. Inhibition FAO by CPT1 inhibitor etomoxir or...
Tumor cells, including cancer stem cells (CSCs) resistant to radio- and chemotherapy, must enhance metabolism meet the extra energy demands repair survive such genotoxic conditions. However, stress-induced adaptive metabolic alterations, especially in that radiotherapy, remain unresolved. In this study, we found CPT1 (Carnitine palmitoyl transferase I) CPT2 II), a pair of rate-limiting enzymes for mitochondrial fatty acid transportation, play critical role increasing oxidation (FAO) required...
Abstract Although the efficacy of cancer radiotherapy (RT) can be enhanced by targeted immunotherapy, immunosuppressive factors induced radiation on tumor cells remain to identified. Here, we report that CD47-mediated anti-phagocytosis is concurrently upregulated with HER2 in radioresistant breast (BC) and RT-treated mouse syngeneic BC. Co-expression both receptors more frequently detected recurrent BC patients poor prognosis. CD47 preferentially HER2-expressing cells, blocking or reduces...
Abstract Ferroptosis, an iron-dependent regulated cell death mechanism, holds significant promise as a therapeutic strategy in oncology. In the current study, we explored regulatory effects of epigallocatechin gallate (EGCG), prominent polyphenol green tea, on ferroptosis and its potential implications for non-small lung cancer (NSCLC). Treatment NSCLC lines with varying concentrations EGCG resulted notable suppression proliferation, evidenced by reduction Ki67 immunofluorescence staining....
Neurofibromatosis type 2 (NF2) is an autosomal-dominant disease that results in the formation of bilateral vestibular schwannomas (VSs) and multiple meningiomas. Treatment options for NF2-associated tumors are limited, to date, no medical therapies FDA approved. The ideal chemotherapeutic agent would inhibit both VS meningiomas simultaneously. objectives this study (1) test efficacy AR42, a novel histone deacetylase inhibitor, meningioma growth (2) investigate drug's mechanisms action....
Abstract Objective To construct and validate a model based on the dual-energy computed tomography (DECT) quantitative parameters radiological features to predict Ki-67 expression levels in pancreatic ductal adenocarcinoma (PDAC). Materials methods Data from 143 PDAC patients were analysed. The variables of clinic, radiology DECT evaluated. In arterial phase portal venous (PVP), normalized iodine concentration (NIC), effective atomic number slope spectral attenuation curves measured....
Cassava is a crucial food and economic crop in tropical regions globally. In response to challenges fertilizer use efficiency for cassava cultivation, which traditionally compromised by extensive leaching broad root zone distribution, novel large-particle slow-release (LPF) was developed this study. This synthesized through solution polymerization using non-metallic minerals seaweed extract. Compared conventional SFs that release 99% of nutrients within 1 min, the LPF prolonged duration 51...
Background Dual induction with all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) has made acute promyelocytic leukemia (APL) a curable disease. However, differentiation syndrome (DS) can be life-threatening complication of therapy. It is considered to result from severe systemic inflammatory response mediated by increased expression cytokines, chemokines, adhesion molecules on differentiating blast cells. The kidney, as vital organ rich in the capillary endothelium, could targeted...
Abstract Fire‐related smoke inhalation‐induced acute lung injury (SI‐ALI) is a prevalent condition in modern fires, characterized by high mortality and lack of targeted therapeutic options. Previous research has been hindered instability generation modeling methods, limiting the investigation SI‐ALI mechanisms. This study, for first time, utilized organ‐on‐a‐chip organoid technologies, optimizing chip design precisely controlling from non‐metallic materials to establish human‐relevant,...
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal of gastrointestinal tract. The mutations in GISTs those receptor tyrosine kinase (KIT) and platelet-derived growth factor alpha (PDGFRA). without KIT or PDGFRA defined as wild-type (WT) GISTs. molecular changes, prognosis, treatments WT remain uncertain. Among GISTs, neurotrophic (NTRK) fusions have rarely been reported. We report a case quadruple GIST harboring novel CDC42BPB::NTRK3 fusion. In this study, we described...
Background Although imaging tools are crucial in identifying features of atherosclerotic plaque, there remains a lack consensus on the use serological markers for assessing high-risk plaques. Methods Patients diagnosed with CAS who met criteria CEA were categorized as operation group, while those without designated control group. Multi-modal was conducted pre- and post-CEA to evaluate plaque features, such volume calcification LRNC, intra-plaque hemorrhage, degree carotid stenosis. Serum...
Eight coding regions designated gag, pol, env, sor, R, tat, art/trs, and 3' orf have been identified in the genome of human immunodeficiency virus type 1 (HIV-1). Several other open reading frames potential to encode additional viral proteins. In this study, we show that HIV-1 has another sequence whose product is expressed during natural infection. Unlike antibody proteins, prevalence encoded by region elevated patients with acquired immune deficiency syndrome (AIDS). Because no analogous...
It has been nearly a century since Otto Loewi discovered that acetylcholine (ACh) release from the vagus produces bradycardia and reduced cardiac contractility. is now known parasympathetic control of heart mediated by ACh stimulation G(i/o)-coupled muscarinic M2 receptors, which directly activate G protein-coupled inwardly rectifying potassium (GIRK) channels via Gβγ resulting in membrane hyperpolarization inhibition action potential (AP) firing. However, expression M2R-GIRK signaling...
Abstract Guillain-Barré syndrome (GBS) is preceded by an infection in about two-thirds of patients. However, the infectious organism often not identified. GBS secondary to Japanese encephalitis virus (JEV) has been reported only India. Herein, we report a case JEV China. A 23-year-old male had generalized weakness, numbness extremities, and bilateral facial nerve paralysis. One week prior, he high fever with headache, several days later, developed diplegia sensory disturbances. Physical...