A5077745456- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Lung Cancer Diagnosis and Treatment
- Cancer-related gene regulation
- Radiomics and Machine Learning in Medical Imaging
- RNA Research and Splicing
- Urinary Bladder and Prostate Research
- Pelvic floor disorders treatments
- MicroRNA in disease regulation
- Spinal Fractures and Fixation Techniques
- Cancer Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Esophageal Cancer Research and Treatment
- Tracheal and airway disorders
- Global Cancer Incidence and Screening
- Myasthenia Gravis and Thymoma
- COVID-19 and healthcare impacts
- Medical Imaging and Analysis
- Urinary Tract Infections Management
- Abdominal Trauma and Injuries
- Plant Physiology and Cultivation Studies
- Cancer Genomics and Diagnostics
- Sperm and Testicular Function
- Sexual Differentiation and Disorders
Sanya University
2024
Hainan University
2024
Xi'an Chest Hospital
2024
Huazhong University of Science and Technology
2019-2022
Tongji Hospital
2019-2022
Weatherford College
2020
Union Hospital
2019
Chinese Center For Disease Control and Prevention
2010
Jining First People's Hospital
2001
Abstract Cancer cell growth, metastasis, and drug resistance pose significant challenges in the management of lung adenocarcinoma (LUAD). However, there is a deficiency optimal predictive models capable accurately forecasting patient prognoses guiding selection targeted treatments. Programmed death (PCD) pathways play pivotal role development progression various cancers, offering potential as prognostic indicators sensitivity markers for LUAD patients. The validation were conducted by...
Among plant metabolites, phenolamides, which are conjugates of hydroxycinnamic acid derivatives and polyamines, play important roles in adaptation to abiotic biotic stresses. However, the molecular mechanisms underlying phenolamide metabolism regulation as well effects domestication breeding on diversity tomato remain largely unclear. In this study, we performed a metabolite-based genome-wide association study identified two biosynthetic gene clusters (BGC7 BGC11) containing 12 genes...
Abstract Ferroptosis, an iron-dependent regulated cell death mechanism, holds significant promise as a therapeutic strategy in oncology. In the current study, we explored regulatory effects of epigallocatechin gallate (EGCG), prominent polyphenol green tea, on ferroptosis and its potential implications for non-small lung cancer (NSCLC). Treatment NSCLC lines with varying concentrations EGCG resulted notable suppression proliferation, evidenced by reduction Ki67 immunofluorescence staining....
Growth arrest associated lncRNA 1 (GASL1) is a newly discovered tumor suppressor long non-coding RNA (lncRNA) in osteosarcoma; however its role other malignancies remains unknown. The aim of the present study was to investigate involvement GASL1 gastric cancer. In current study, cancer tissue and adjacent healthy samples were collected from patients with carcinoma, blood carcinoma controls detect expression serum GASL1. All followed up for 5 years diagnostic prognostic value evaluated by ROC...
To compare the perioperative and follow-up outcomes of patients with myasthenia gravis (MG) receiving subxiphoid-subcostal or unilateral thoracoscopic thymectomy to identify factors affecting MG prognosis.From January 2013 December 2019, a total 137 consecutive received (STT, n = 65) conventional (UTT, 72). The primary this study were complications, duration expenses hospitalization, VAS score complete stable remission (CSR).The STT had significantly shorter drainage postoperative hospital...
Abstract Background It has been established that microRNA (miR)-449a is anti-tumorigenic in cancers, including lung cancer. Therefore, this study further explored miR-449a-mediated mechanism cancer, mainly focusing on lysine demethylase 3A/hypoxia-induced factor-1α (KDM3A/HIF-1α) axis. Methods miR-449a, KDM3A and HIF-1α levels cancer tissues cell lines (A549, H1299 H460) were measured. Loss- gain-of-function assays performed then proliferation, cycle, apoptosis, invasion migration traced....
Tumor metastasis is still an insurmountable obstacle in tumor treatment. Lung cancer represents one of the most common malignancies with high morbidity worldwide. hnRNPA1 has been reported to be involved regulation metastasis, while its specific role seems controversial and molecular mechanism lung remains further elucidated. In this study, we confirmed that knockdown led enhanced migration, invasion EMT transition cells. Bioinformatics analysis GSE34992 dataset revealed may regulate...
The survival rate of patients with lung adenocarcinoma (LUAD) is low. This study analyzed the correlation between expression long noncoding RNA (lncRNA) and epigenetic alterations along investigation prognostic value these outcomes for LUAD. Differentially expressed lncRNAs were identified based on multiomic data positively related genes using DESeq2 in R, differentially histone-modifying specific to LUAD histone modification data, gene enhancers from information collected FANTOM5 (Function...
Pulmonary carcinosarcomas (PCSs) are a heterogeneous group of non-small-cell lung carcinomas (NSCLCs) with aggressiveness and poor prognosis. Although genetic mutations some common cancer subtypes have been extensively studied, the molecular characteristics PCSs existence abnormal target genes unknown.In this study, clinical characterization in 3 pulmonary sarcomatoid (PSCs) were presented using microscope analysis next-generation sequencing (NGS) analysis.The results revealed subtype...
Background . Glycolysis is closely associated with tumor progression, but the roles of lncRNAs in glycolysis have not been comprehensively investigated lung adenocarcinoma (LUAD). This study aimed at studying possible mechanisms glycolysis‐related development and providing a guidance for targeted therapy. Methods Unsupervised consensus clustering was used to identify molecular subtypes. Gene enrichment analysis applied screen important pathways involved progression. A series immune performed...
Circular RNAs (circRNAs) have been demonstrated as potential biomarkers for the diagnosis and treatment of human diseases. Previous studies unveiled carcinogenic role circRNA_102399 (circCNN2) in lung cancer. Through UALCAN database, it was found that CNN2, parent gene circCNN2, specifically highly expressed squamous cell carcinoma (LUSC) cells, but regulatory mechanism circCNN2 LUSC is unclear. In this study, expression cells examined via RT-qPCR, its effects on progression verified through...
Objectives . To evaluate the effects of pentobarbital dosages on lower urinary tract function and to define an appropriate dosage sodium that would be suitable for urodynamic studies in which recovery from anesthesia long term survive were needed subsequent experiment. Methods Twenty-four 8-week-old, female, virgin, Sprague-Dawley rats (200-250 g) used this study. Rats study groups received gradient doses intraperitoneally, those control group urethane intraperitoneally. External urethral...
Currently, COVID-19 has made a significant impact on many countries in the world. However, there have been no reported cases of pulmonary lobectomy with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) infection. We are first to report such case.We 63-year-old Wuhan male patient smoking history 40 cigarettes per day for years. He sought medical consultation right lower lung nodules found by CT scan.The patient's postoperative pathological diagnosis was squamous cell carcinoma...
Understanding the genomic landscape of early-stage lung adenocarcinoma (LUAD) may provide new insights into molecular evolution in early stages LUAD.Through sequencing 79 spatially distinct regions from 37 patients with ground glass opacities (GGOs), we provided a comprehensive mutational GGOs, highlighting importance ancestry differences.Our study had several interesting features. First, epidermal growth factor receptor (EGFR), BRAF (v-RAF murine sarcoma viral oncogene homologue B1), and...
The widespread use of low-dose chest CT screening has improved the detection early lung adenocarcinoma. Radical surgery is best treatment strategy for patients with adenocarcinoma; however, some present postoperative recurrence and poor prognosis. Through this study, we hope to establish a model that can identify are prone have prognosis after adenocarcinoma.We screened prognostic relapse-related genes using Cancer Genome Atlas (TCGA) database GSE50081 dataset from Gene Expression Omnibus...
Objective To investigate the anatomical tips of submandibular approach surgery and evaluate effectiveness this for surgical treatment Hangman's fracture. Methods Major vessels nerves in area 5 corpses were observed. The minimum vertical distance between hypoglossal nerve internal branch laryngeal was measured. included 3 males 2 females, aged from 39 to 62 years, without history cervical related diseases. Twenty-one patients Hangman fracture treated with reviewed. There 14 7 27 59...