A5100762731- Urinary Bladder and Prostate Research
- Hormonal and reproductive studies
- Multiple Sclerosis Research Studies
- Sexual function and dysfunction studies
- Retinal and Optic Conditions
- Peripheral Neuropathies and Disorders
- Ocular Diseases and Behçet’s Syndrome
- Pelvic floor disorders treatments
- Angiogenesis and VEGF in Cancer
- Urinary Tract Infections Management
- Cardiac Fibrosis and Remodeling
- Transplantation: Methods and Outcomes
- Liver physiology and pathology
- Schizophrenia research and treatment
- Glaucoma and retinal disorders
- Heart Failure Treatment and Management
- S100 Proteins and Annexins
- Hepatitis B Virus Studies
- Signaling Pathways in Disease
- Sexuality, Behavior, and Technology
- Molecular Communication and Nanonetworks
- RNA modifications and cancer
- Gene Regulatory Network Analysis
- Acute Myocardial Infarction Research
- High Altitude and Hypoxia
Shanghai Chest Hospital
2022
Shanghai Jiao Tong University
2022
Tongji Hospital
2013-2020
Huazhong University of Science and Technology
2006-2020
Union Hospital
2013-2020
Biogen (United States)
2014-2018
Beihua University
2018
Chinese General Hospital College of Nursing and Liberal Arts
2018
Chinese People's Liberation Army
2018
Amsterdam UMC Location Vrije Universiteit Amsterdam
2014
This study was designed to evaluate the short-term efficacy and safety of once-daily lurasidone (80 mg/day 160 mg/day) in treatment an acute exacerbation schizophrenia. Participants, who were recently admitted inpatients with schizophrenia psychotic symptoms, randomly assigned 6 weeks fixed-dose, double-blind 80 mg (n = 125), 121), quetiapine XR 600 (QXR-600 mg; n 119; active control included test for assay sensitivity), or placebo all dosed once daily evening. Efficacy evaluated using a...
No AccessJournal of UrologyAdult Urology1 Mar 2010Urodynamic Effects Once Daily Tadalafil in Men With Lower Urinary Tract Symptoms Secondary to Clinical Benign Prostatic Hyperplasia: A Randomized, Placebo Controlled 12-Week Trialis companion ofUrodynamic Trial Roger Dmochowski, Claus Roehrborn, Suzanne Klise, Lei Xu, Jed Kaminetsky, and Stephen Kraus DmochowskiRoger Dmochowski Department Urology, Vanderbilt University, Nashville, Tennessee , RoehrbornClaus Roehrborn UT Southwestern Medical...
<h3>Objective:</h3> To evaluate the safety, tolerability, and pharmacokinetics (PK) of BIIB033 (anti-LINGO-1 monoclonal antibody) in healthy volunteers participants with multiple sclerosis (MS). <h3>Methods:</h3> In 2 separate randomized, placebo-controlled studies, single ascending doses (SAD; 0.1–100 mg/kg) or placebo were administered via IV infusion subcutaneous injection to 72 volunteers, (MAD; 0.3–100 mg/kg; separated by 14 days) 47 relapsing-remitting secondary progressive MS. Safety...
Abstract Objective To compare the difference of SARS-CoV-2 IgG antibody between male and female COVID-19 patients figure out a possible explanation for different outcome patients. Methods A total number 331 confirmed infection were enrolled. The plasma these collected during hospitalization detected antibody. Afterwards, was analyzed. Results level in mild, general recovering showed on female. In severe status, average tended to be higher than that Compared with patients, most generated...
Nav1.7 is considered a promising target for developing next-generation analgesic drugs, given its critical role in human pain pathologies. Although most reported inhibitors with strong vitro activity and high selectivity share the aryl sulfonamide scaffold, they failed to demonstrate marked clinical efficacy. Therefore, exploring new Nav1.7-selective antagonists quite urgent development of drugs. Here, we report highly effective 1H-indole-3-propionamide inhibitor, WN2, identified through an...
Objectives To assess the safety and efficacy of tadalafil once daily on lower urinary tract symptoms suggestive clinical benign prostatic hyperplasia ( BPH‐LUTS ) in men without erectile dysfunction ED ). compare these with effects . Patients Methods After a 4‐week washout period placebo run‐in period, 1089 n = 338) 751) were randomly assigned to or 5 mg for 12 weeks three global studies similar designs. In pooled dataset, post hoc analyses covariance assessed impact severity using I...
BackgroundExercise training protects the heart against pathological cardiac remodeling and confers cardioprotection from failure. However, underlying mechanism is still elusive.MethodsAn integrative analysis of multi-omics data skeletal muscle in response to exercise performed search for potential exerkine. Then, CCDC80tide examined humans after acute exercise. The role assessed a mouse model hypertensive hypertension-mediated cell injury models. transcriptomic immunoprecipitation assay are...
Little is known about the long-term outcomes for patients with schizophrenia who fail to achieve symptomatic remission. This post-hoc analysis of a 3-year study compared costs mental health services and functional between individuals met or did not meet cross-sectional symptom remission at enrollment. used data from large, prospective, non-interventional observational treated in United States conducted July 1997 September 2003. At enrollment, were classified as non-remitted remitted using...
SUMMARY To detect the expression of pro-fibrotic molecules, such as heat shock protein 47 (Hsp47), transforming growth factor-beta 1 (TGF- β 1) and connective tissue factor (CTGF) in liver specimens, analyse their correlations with progression schistosomal hepatic fibrosis, biopsy was performed 42 chronic schistosomiasis (CS) patients, 16 hepatitis B (CHB) patients five healthy individuals (HI). Immunohistochemistry (IHC) analyses displayed that Hsp47, TGF- CTGF increased CS CHB compared HI....
The objective of this study was to evaluate prespecified and post hoc analyses in RENEW subgroups identify participants more likely benefit from opicinumab.RENEW assessed the efficacy/safety opicinumab versus placebo with a first unilateral acute optic neuritis (AON) episode. Difference visual evoked potential (VEP) latency affected eye at 24 weeks fellow baseline primary endpoint. Interactions between endpoint variables (including age, timing treatment initiation, impairment) using median...
Leucine-rich repeat and immunoglobulin domain-containing Nogo receptor-interacting protein 1 (LINGO-1) is a key suppressor of oligodendrocyte differentiation axonal remyelination regeneration. This analysis evaluated the potential benefit opicinumab, human monoclonal antibody against LINGO-1, vs placebo on exploratory clinical endpoints patient-reported vision-related functioning high-contrast visual acuity (HCVA) in RENEW participants with acute optic neuritis (AON).Participants were...
OBJECTIVE: To determine the efficacy of anti-LINGO-1 antibody BIIB033 in subjects with a first episode acute optic neuritis (AON). BACKGROUND: The demyelination and axonal injury during AON usually results permanent structural functional visual deficits. Although corticosteroid treatment can accelerate rate spontaneous recovery, no reparative is available to reduce sequelae AON. LINGO-1 CNS-specific membrane glycoprotein that suppresses oligodendrocyte differentiation myelination. fully...
To establish a rapid method for the stat laboratory to identify falsely elevated serum cardiac troponin I (cTnI) values caused by endogenous interferences. Serum specimens with cTnI were recentrifuged and was measured again. If difference between first second value less than +/− 30%, specimen diluted 1:2, 1:5, 1:10, in specimens. concentrations did not change linearly dilution, referred an outside lab re-analysis of different immunochemical method. Troponin 132 In 18 specimens, we attributed...
This study aimed to evaluate the clinical applicability of plasma copeptin level assess heart failure with reduced left ventricular ejection fraction (HFrEF).One hundred thirty-one patients HFrEF, 127 preserved (HFpEF), and 119 healthy candidates were involved. The basic data examination results collected. function HFrEF HFpEF graded on basis criteria New York Heart Association (NYHA) classification. N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels tested using enzyme-linked...
RF(Rheumatoid factor) is usually thought to cause positive interference in immunoassay. Recently, our study showed that high-concentration RFs caused negative as well serum HBsAg(Hepatitis B surface antigen) ELISA(Enzyme-linked immunosorbent assay), but it unclear RF causing an anomaly produced by a certain ELISA kit or common property of most HBsAg kits.Serum models were made blending HBsAg-positive sera and high- moderate-concentration at the ratio 1: 9, then one-step two-step adopted...
Background The indirect antiglobulin test (IAT) and direct (DAT) have been used as common tests for transfusion. Recently, we found that in addition to causing false increases, rheumatoid factor (RF) can also cause decreases immunoassays hepatitis B surface antigen B-type natriuretic peptide. However, it remains unclear whether RF interferes with the IAT DAT. Methods models were produced by mixing IAT-positive plasma RF-positive plasma, then one-step two-step IATs adopted detection. DAT...
The chemiluminescent microparticle immunoassay (CMIA) is widely used for the quantitative determination of B-type natriuretic peptide (BNP) in human ethylenediaminetetraacetic acid plasma. Rheumatoid factor (RF) usually thought to result a positive interference immunoassays, but it not clear whether its presence plasma can lead interferences CMIA BNP.The estimation BNP recovery was carried out by diluting high-concentration samples with RF-positive or RF-negative at ratio 1:9. diluted were...
Background Rheumatoid factor causes positive interference in multiple immunoassays. Recently, negative has also been found immunoassays the presence of rheumatoid factor. The chemiluminescent microparticle immunoassay is widely used to determine serum alpha-fetoprotein. However, it not clear whether Methods Serum alpha-fetoprotein was determined using ARCHITECT assay. estimation recovery carried out samples prepared by diluting high-concentration with factor-positive or factor-negative...