A5101613450- DNA and Nucleic Acid Chemistry
- Advanced biosensing and bioanalysis techniques
- Glycosylation and Glycoproteins Research
- Metal complexes synthesis and properties
- Mass Spectrometry Techniques and Applications
- Cardiovascular Function and Risk Factors
- Graphene and Nanomaterials Applications
- Cardiac Imaging and Diagnostics
- Image and Signal Denoising Methods
- Vascular Malformations and Hemangiomas
- RNA Interference and Gene Delivery
- Cancer, Hypoxia, and Metabolism
- Advanced SAR Imaging Techniques
- Image Enhancement Techniques
- Ferrocene Chemistry and Applications
- Analytical chemistry methods development
- Graphene research and applications
- Ion-surface interactions and analysis
- Membrane Separation Technologies
- Enzyme Structure and Function
- Advanced Image Fusion Techniques
- Advanced Proteomics Techniques and Applications
- Sparse and Compressive Sensing Techniques
- COVID-19 Clinical Research Studies
- Advanced MRI Techniques and Applications
Second Affiliated Hospital of Nanchang University
2025
Nanchang University
2024-2025
Sichuan University
2021-2024
Union Hospital
2016-2024
Huazhong University of Science and Technology
2016-2024
West China Hospital of Sichuan University
2024
First Affiliated Hospital of Jiangxi Medical College
2024
Hunan International Economics University
2010-2023
The Central Hospital of Shaoyang
2023
First Affiliated Hospital of Jinan University
2022
DNA G-quadruplexes are not only attractive drug targets for cancer therapeutics, but also have important applications in supramolecular assembly. Here, we report a platinum(II)-based tripod (Pt-tripod) specifically binds the biological relevant hybrid-1 human telomeric G-quadruplex (Tel26), and strongly inhibits telomerase activity. Further investigations illustrate Pt-tripod induces formation of monomeric multimeric Pt-tripod‒Tel26 complex structures solution. We solve 1:1 unique dimeric...
Cardiac magnetic resonance (CMR) T1 mapping and tissue-tracking strain analysis are useful quantitative techniques that can characterize myocardial tissue mechanical alterations, respectively, in patients with early diabetic cardiomyopathy. The purpose of this study was to assess the left ventricular value, extracellular volume fraction (ECV), systolic asymptomatic type 2 diabetes mellitus (T2DM) their underlying relationships clinical parameters. We recruited 50 T2DM (mean age: 55 ± 7...
An efficient palladium-catalyzed Suzuki coupling of 1,1-diarylmethyl-trimethylammonium triflates with arylboronic acids is reported. This reaction offers a novel approach to triarylmethane derivatives in good excellent yields the C–N bond cleavage as key feature. Broad substrate scope regarding both partners are observed. Moreover, reactive functional groups such vinyl and formyl conserved this transformation.
Platinum(II) terpyridine complexes has attracted increasing attention as they have displayed great potential antitumor agents due to their high intercalation affinity with nucleic acids. Epidermal growth factor receptor (EGFR) is often overexpressed in various tumor cells, leading uncontrolled of tumor, and regarded an important target for developing novel drugs. Herein, we report four platinum(II) bearing EGFR inhibiting 4-anilinoquinazoline derivatives potent multi-targeting...
Site-specific N-glycosylation characterization requires intact N-glycopeptide analysis based on suitable tandem mass spectrometry (MS/MS) method. Electron-transfer/higher-energy collisional dissociation (EThcD), stepped collision energy/higher-energy (sceHCD), higher-energy dissociation-product-dependent electron-transfer (HCD-pd-ETD), and a hybrid fragmentation method EThcD-sceHCD have emerged as valuable approaches for glycoprotein analysis. However, each of them incurs some compromise,...
Over the past decades, various microfluidic devices have been developed to investigate role of molecular gradient in axonal development; however, there are very few providing quantitative information about response axons gradients with different slopes. Here, we propose a novel laminar-based device enabling simultaneous generation multiple gradually changed slope on single chip. This device, two asymmetrically designed peripheral channels and opposite flow direction, could generate center...
The understanding of ion solvation phenomena is significance due to their influences on many important chemical, biological, and environmental processes. Mass spectrometry (MS)-based methods have been used investigate this topic with molecular insights. As ion–solvent interactions are weak, ionization processes should be as soft possible in order retain structures. An situ liquid secondary MS (SIMS) approach developed our group has recently utilized investigations Li nonaqueous solution, it...
In multiple primary lung adenocarcinomas (MPLAs), the relationship between imaging and gene mutations remains unclear. This retrospective study aimed to identify correlation of epidermal growth factor receptor (EGFR) anaplastic lymphoma kinase (ALK) status with CT characteristics in MPLA patients.Sixty-seven patients (135 lesions) MPLAs confirmed by pathology were selected from our institution. All subjects tested for EGFR ALK underwent chest prior any treatment. The criteria definitions...
Chemoresistance is the major restriction on clinical use of cisplatin. Aberrant changes in protein glycosylation are closely associated with drug resistance. Comprehensive study role development cisplatin resistance would contribute to precise elucidation complicated mechanism However, comprehensive characterization glycosylated proteins remains a big challenge. In this work, we integrated proteomic and N-glycoproteomic workflow comprehensively characterize resistance-related membrane...
To evaluate the diagnostic performance of left coronary bifurcation angles and plaque characteristics for prediction stenosis by dual-source CT.106 patients suspected artery disease undergoing both computed tomography angiography (CCTA) invasive (CAG) within three months were included. Left including between anterior descending circumflex (LAD-LCx), main (LM-LAD), (LM-LCx) measured on CT images. CCTA parameters calculated analysis software. Coronary ≥ 50% CAG was defined as significant.106...
The clinically widely-used anticancer drug, cisplatin, binds strongly to DNA as a DNA-damaging agent. Herein, we investigated the interaction of cisplatin with 15-mer single-stranded C,T-rich oligodeoxynucleotide, 5′-CCTT4CTT7G8C9T10TCTCC-3′ (ODN15), using ultra-high resolution Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) in conjunction tandem (top-down MS). Top-down MS analysis collision-induced dissociation (CID) fragmentation mono-platinated and di-platinated...
Deciphering the glycosylation of viral envelope (Env) glycoprotein is critical for evaluating escape from host's immune response and developing vaccines antiviral drugs. However, it still challenging to precisely decode site-specific characteristics highly glycosylated Env proteins, although glycoproteomics have made significant advances in mass spectrometry techniques data analysis tools. Here, we present a hybrid dissociation technique, EThcD-sceHCD, by combining electron...
A new proteomic strategy combining functionalized magnetic nanoparticle affinity probes with mass spectrometry was developed to capture and identify proteins specifically responding 1,2-d(GpG) intrastrand cisplatin-cross-linked DNA, the major DNA lesion caused by cisplatin thought induce apoptosis. 16-mer oligodeoxynucleotide (ODN) duplex its adduct were immobilized on nanoparticles via click reaction, respectively, fabricate negative positive which very stable in cellular protein extracts...
Monoclonal immunoglobulin produced by clonal plasma cells is the main cause in multiple myeloma and monoclonal gammopathy of renal significance. Because complicated purification method low stoichiometry purified protein glycans, site-specific N-glycosylation characterization for still challenging. To profile immunoglobulins great interest. Therefore, this study, we presented an integrated workflow micro IgA IgG from patients with HYDRASYS system, in-agarose-gel digestion, LC-MS/MS analysis...
Image enhancement is a very important process of image preprocessing and it plays critical role in the improvement quality follow-up analysis, which makes research algorithm hot field. not only needs to strengthen determination recognition, but also avoid consequential color distortion. Pseudo-color technique map different gray scales black-and-white into image. As humans have extremely strong ability distinguishing colors visually relatively weak capacity discriminating scales, so,...
This letter proposes a synthetic aperture radar (SAR) target recognition method via joint classification of deep features fused by multi-canonical correlation analysis (MCCA). A convolutional neural network (CNN) is designed for feature learning from original SAR images. For the multiple maps different convolution layers, they are based on MCCA to maintain relevance while eliminating redundancy. Afterwards, sparse representation (JSR) employed jointly represent vectors layers under...
ObjectivesWe aimed to explore the effect of antiretroviral treatment (ART) history on clinical characteristics patients with co-infection SARS-CoV-2 and HIV.MethodsWe retrospectively reviewed 20 laboratory-confirmed HIV in a designated hospital. Patients were divided into medicine group (n = 12) non-medicine 8) according previous ART before infection.ResultsThe median age was 46.5 years 15 (75%) female. Ten had initial negative RT-PCR admission, 5 which normal CT appearance 4 asymptomatic....