A5032087142- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Multiple Sclerosis Research Studies
- Advanced MRI Techniques and Applications
- Polyomavirus and related diseases
- Cruise Tourism Development and Management
- Cardiomyopathy and Myosin Studies
- Chronic Lymphocytic Leukemia Research
- COVID-19 Clinical Research Studies
- Lung Cancer Treatments and Mutations
- Long-Term Effects of COVID-19
- Acute Lymphoblastic Leukemia research
- Data Management and Algorithms
- HVDC Systems and Fault Protection
- Lymphoma Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Peripheral Neuropathies and Disorders
- Colorectal Cancer Treatments and Studies
- Monoclonal and Polyclonal Antibodies Research
- Cardiovascular Disease and Adiposity
- Maritime Transport Emissions and Efficiency
- Cardiac Structural Anomalies and Repair
- Advanced Database Systems and Queries
- Melanoma and MAPK Pathways
- Radiopharmaceutical Chemistry and Applications
Huazhong University of Science and Technology
2015-2025
Union Hospital
2016-2025
State Key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing
2019-2025
Hubei Provincial Center for Disease Control and Prevention
2025
Wuhan Union Hospital
2020-2025
Sangamo BioSciences (United States)
2024
University of Sheffield
2024
North China Electric Power University
2012-2022
Peking University Third Hospital
2019-2021
Peking University
2019-2021
BCL2 overexpression is a hallmark of chronic lymphocytic leukemia (CLL). The novel BH3 mimetic navitoclax (ABT-263) specifically inhibits and related proteins BCL-x(l) BCL-w, potently inducing apoptosis CLL cells in vitro. A phase I trial patients with was conducted to evaluate the safety, pharmacokinetics, biologic activity oral navitoclax.Twenty-nine relapsed or refractory received daily for 14 days (10, 110, 200, 250 mg/d; n = 15) 21 (125, 250, 300 14) each 21-day cycle. Dose escalation...
Cardiac magnetic resonance (CMR) T1 mapping and tissue-tracking strain analysis are useful quantitative techniques that can characterize myocardial tissue mechanical alterations, respectively, in patients with early diabetic cardiomyopathy. The purpose of this study was to assess the left ventricular value, extracellular volume fraction (ECV), systolic asymptomatic type 2 diabetes mellitus (T2DM) their underlying relationships clinical parameters. We recruited 50 T2DM (mean age: 55 ± 7...
Background Early detection of subclinical myocardial dysfunction in asymptomatic patients with type 2 diabetes mellitus (T2DM) is essential before overt changes left ventricular ejection fraction (LVEF) and strain occur. The objective this study to quantitatively assess hemodynamic forces (HDFs) using a rigorous mathematical model based on conventional cine cardiac magnetic resonance (CMR) images T2DM, investigate their correlation late gadolinium enhancement (LGE) duration diabetes. Methods...
To investigate the value of pretreatment nasopharyngeal and neck magnetic resonance imaging (NN-MRI) combined with positron emission tomography (PET)/CT-guided therapy for improving survival in upper aerodigestive tract NK/T-cell lymphoma (UADT-NKTL) patients. We performed a prospective cohort study including 171 untreated patients histologically diagnosed UADT-NKTL, whom 71 received PET/CT NN-MRI other 100 alone. The clinical stage every patient was classified according to Ann Arbor TNM...
Cardiovascular magnetic resonance (CMR)-derived extracellular volume (ECV) and tissue tracking strain analyses are proposed as non-invasive methods for quantifying myocardial fibrosis deformation. This study sought (1) to histologically validate ECV against the collagen fraction (CVF) measured from samples of patients undergoing heart transplantation (2) detect correlations between systolic histological CVF in transplantation. A total 12 dilated cardiomyopathy (DCM) 10 ischaemic (ICM)...
To evaluate the diagnostic performance of left coronary bifurcation angles and plaque characteristics for prediction stenosis by dual-source CT.106 patients suspected artery disease undergoing both computed tomography angiography (CCTA) invasive (CAG) within three months were included. Left including between anterior descending circumflex (LAD-LCx), main (LM-LAD), (LM-LCx) measured on CT images. CCTA parameters calculated analysis software. Coronary ≥ 50% CAG was defined as significant.106...
Background: Efficacy of interferon beta in multiple sclerosis (MS) can be dampened patients who develop neutralizing antidrug antibodies (NAbs). Peginterferon beta1a is an conjugated with a polyethylene glycol (PEG) moiety. Pegylation increases drug’s half life and exposure, may also reduce immunogenicity. Objective: The objective this study was to characterize the incidence impact immunogenicity peginterferon over 2 years MS. Methods: Patients relapsing–remitting MS ( N = 1512) were...
Abstract Background Previous studies have found that impaired global myocardial systolic strain is associated with cardiovascular events in T2DM patients. However, the effect of hypertension (HT) on left atrial (LA), right ventricular (RV) and (LV) deformation hypertensive patients has not been fully studied by cardiac magnetic resonance feature tracking (CMR-FT). Our aim was to assess LA, RV LV T2DM-HT without using CMR-FT determine underlying relationships clinical parameters. Methods A...
Social media are transforming communication between organizations and their audiences, even changing the themselves. media's low cost requirements for technical skills needed to both use maintain an online presence allow small businesses with limited marketing budgets same strategies as bigger large budgets. In addition, social provides direct interactive ways reach out retain customers. This case study analyzes Cedar Park Farmers Market (CPFM)'s of its Facebook page. Using Graph API...
Abstract The aim of this study was to assess the prognostic value baseline clinical and high resolution CT (HRCT) findings in patients with severe COVID-19. In retrospective, two-center study, we included two groups inpatients COVID-19 who had been discharged or died Jin Yin-tan hospital Wuhan union between January 5, 2020, February 22, 2020. Cases were confirmed by real-time polymerase chain reaction. Demographic, clinical, laboratory data, HRCT imaging collected compared deceased patients....
To determine chest CT changes 6 months and 12 after the onset of coronavirus disease 2019 (COVID-19) in patients with diabetes or hyperglycemia risk factors for these residual lung abnormalities.
Aims To evaluate the pharmacokinetics (PK) and pharmacodynamics (PD) of subcutaneous peginterferon beta‐1a in patients with relapsing‐remitting multiple sclerosis ( RRMS ) phase 3 ADVANCE study n = 1512). Methods During year 1, were randomized (1:1:1) to placebo or 125 μg every 2 4 weeks. After re‐randomized administered weeks for 2. Patients 1 remained on same dosing regimen Intensive blood samples PK PD (neopterin elevation; a biomarker pharmacological activity induced by interferon...
ADVANCE was a phase III trial of the efficacy and safety subcutaneous peginterferon beta-1a 125 µg every 2 or 4 weeks in patients with relapsing-remitting multiple sclerosis (RRMS). ATTAIN 2-year extension study ADVANCE. The aim to evaluate long-term safety, tolerability, ATTAIN.ADVANCE dosing schedules were maintained ATTAIN, except that every-4-weeks switched every-2-weeks after conversion an open-label protocol. considered complete when last patient completed 96-week study. Primary...
An improved analytical tuning rule of a Proportional-Integral-Derivative (PID) controller for integrating systems with time delay is proposed using the direct synthesis method and multiple dominant pole-placement approach. Different from traditional method, desired characteristic equation obtained by placing third-order poles at −1/λ second-order non-dominant −5/λ (λ parameter). According to root locus theory, are nearly symmetrically located two sides fifth-order poles. This makes closer...
Abstract Myocardial fibrosis assessed by late gadolinium enhancement (LGE) on cardiovascular magnetic resonance (CMR) is associated with outcomes in hypertrophic cardiomyopathy (HCM) patients, but little known about the utility of non-invasive markers for detecting LGE. This study aims to explore association between cardiac-specific biomarkers, CMR myocardial strain, left ventricular (LV) hypertrophy and LGE HCM patients preserved ejection fraction (EF) investigate predictive values these...
Methods This was a single-dose, open-label, 3-period crossover study with randomized, design. Healthy male and female subjects (n = 27) participated in the study. Serial blood samples were collected for 36 hours after each dose. Ritonavir AUC from time 0 to last measurable concentration (AUCt) infinity (AUCinf), maximum plasma (Cmax), of Cmax (Tmax) determined using noncompartmental methods. The bioavailability tablet following meal relative fasting condition assessed by two one-sided tests...