A5004452315- COVID-19 Clinical Research Studies
- Wound Healing and Treatments
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Dermatologic Treatments and Research
- Mesenchymal stem cell research
- Diabetic Foot Ulcer Assessment and Management
- Extracellular vesicles in disease
- Pressure Ulcer Prevention and Management
- IL-33, ST2, and ILC Pathways
- Autoimmune Bullous Skin Diseases
- Cardiovascular Disease and Adiposity
- Electrospun Nanofibers in Biomedical Applications
- Hair Growth and Disorders
- Dermatology and Skin Diseases
- COVID-19 and healthcare impacts
- Fibroblast Growth Factor Research
- Immune Response and Inflammation
- Connective Tissue Growth Factor Research
- Immune cells in cancer
- Phagocytosis and Immune Regulation
- melanin and skin pigmentation
- Gut microbiota and health
- Adipokines, Inflammation, and Metabolic Diseases
- Ferroptosis and cancer prognosis
The First Affiliated Hospital, Sun Yat-sen University
2017-2025
Sun Yat-sen University
2017-2025
Tianjin Medical University General Hospital
2025
Guangdong Medical College
2025
South China Agricultural University
2024
University of California, Irvine
2017-2023
University of South Carolina
2020-2023
Sun Yat-sen University Cancer Center
2017-2023
Sichuan University
2023
State Key Laboratory of Oral Diseases
2023
Moderate inflammation is essential for standard wound healing. In pathological conditions, such as diabetes, protracted and refractory wounds are associated with excessive inflammation, manifested by persistent proinflammatory macrophage states. However, the mechanisms still unclear. Herein, we perform a metabolomic profile find significant phenylpyruvate accumulation in diabetic foot ulcers. Increased impairs healing augments inflammatory responses, whereas reducing via dietary...
In this retrospective study, we evaluated the levels of a series serum biomarkers in coronavirus disease 2019 (COVID-19) patients (mild: 131; severe: 98; critical: 23). We found that there were significant increases human epididymis protein 4 (HE4) (73.6 ± 38.3 vs 46.5 14.7 pmol/L; P < .001), cytokeratin-19 fragment (CYFRA21-1) (2.2 0.9 1.9 0.8 μg/L; carcinoembryonic antigen (CEA) (3.4 2.2 2.1 1.2 carbohydrate antigens (CA) 125 (18.1 13.5 10.5 4.6 and 153 (14.4 8.9 10.1 4.4 .001) COVID-19...
Niche signals maintain stem cells in a prolonged quiescence or transiently activate them for proper regeneration1. Altering balanced niche signalling can lead to regenerative disorders. Melanocytic skin nevi human often display excessive hair growth, suggesting cell hyperactivity. Here, using genetic mouse models of nevi2,3, we show that dermal clusters senescent melanocytes drive epithelial exit and change their transcriptome composition, potently enhancing renewal. Nevus distinct...
The control principles behind robust cyclic regeneration of hair follicles (HFs) remain unclear. Using multi-scale modeling, we show that coupling inhibitors and activators with physical growth HFs is sufficient to drive periodicity excitability regeneration. Model simulations experimental data reveal mouse skin behaves as a heterogeneous regenerative field, composed anatomical domains where have distinct cycling dynamics. Interactions between fast-cycling chin ventral slow-cycling dorsal...
As the pandemic evolves, post-acute sequelae of CoV-2 (PASC) including cardiovascular manifestations have emerged as a new health threat. This study aims to whether Spike protein plus obesity can exacerbate PASC-related cardiomyopathy.A protein-pseudotyped (Spp) virus with proper surface tropism SARS-CoV-2 was developed for viral entry assay in vitro and administration into high fat diet (HFD)-fed mice. The systemic loads cardiac transcriptomes were analyzed at 2 24 h, 3, 6, weeks post...
Abstract The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) plays a crucial role in mediating viral entry into host cells. However, whether it contributes to pulmonary hyperinflammation patients with disease 2019 is not well known. In this study, we developed protein–pseudotyped (Spp) lentivirus the proper tropism SARS‐CoV‐2 on surface and determined distribution Spp wild‐type C57BL/6J male mice that received an intravenous injection virus. Lentiviruses...
Abstract Background COVID-19 patients develop hypolipidemia. However, it is unknown whether lipid levels have improved and there are potential sequlae in recovered patients. Objective In this follow-up study, we evaluated serum lipidemia various physiopathological laboratory values Methods A 3–6 month study was performed between June 15 September 3, 2020, to examine of 107 discharged (mild = 59; severe/critical 48; diagnoses on admission). Sixty-one had a revisit chest CT scan. Wilcoxon...
The dysfunction of endothelial cells caused by hyperglycemia is observed as a decrease in neovascularization diabetic wound healing. Studies have found that epidermal stem (EpiSCs) can promote the angiogenesis full-thickness wounds. To further explain therapeutic effect EpiSCs, EpiSC–derived exosomes (EpiSC-EXOs) are considered main substance contributing to cell effectivity. In our study, EpiSCs and EpiSC-EXOs were supplied dorsal wounds db/db mice. Results showed could colonize area both...
Skin fibrosis is a lesion in the dermis causing to itching, pain, and psychological stress. The gut microbiome plays as an essential role skin diseases developments. We conducted Mendelian randomization study determine causal association between fibrosis.
Although the relationship between macroautophagy/autophagy and Alzheimer disease (AD) is widely studied, underlying mechanisms are poorly understood, especially regulatory role of initiation signaling autophagy on AD. Here, we find that ER transmembrane protein CANX (calnexin) a novel interaction partner autophagy-inducing kinase ULK1 required for recruitment to under basal or starved conditions. Loss results in inactivity inhibits flux. In brains people with AD APP-PSEN1 mice, declines....
Abstract Background Approximately 30% of patients with Crohn’s disease (CD) experience primary loss response (PLR) administrated ustekinumab (UST) [1]. Unlike the assessment traditional biologic treatments, there is still a lack studies that thoroughly integrate imaging parameters to evaluate UST for disease. This study aims precisely quantify endoluminal and intestinal wall from computed tomography enterography (CTE) predict PLR. Methods multicentre included 466 segments 161 CD between...
Diabetic wound healing remains a significant clinical challenge because of hyperglycaemia-induced cellular senescence, impaired angiogenesis, and chronic inflammation. To address these issues, we developed multifunctional hydrogel (GelMA/PNS/Alg@IGF-1) that integrates gelatine methacryloyl (GelMA), Panax notoginseng saponins (PNS), sodium alginate microspheres encapsulating insulin-like growth factor-1 (IGF-1). This was engineered to achieve gradient sustained release bioactive agents target...
Skin fibrosis is a dermal lesion associated with inflammatory factors. However, the exact causal relationship between circulating proteins (CIPs) and skin remains unclear. To investigate this potential association mediated effect, Mendelian randomization (MR) two-step MR were used. Summary statistics from genome-wide studies (GWAS) extracted GWAS Catalog for CIPs, blood metabolites (BMs), fibrosis. Two-sample reverse conducted to determine effect of CIPs on Two-step was then performed role...
Coronavirus disease 2019 (COVID-19) patients show lipid metabolic alterations, but the mechanism remains unknown. In this study, we aimed to investigate whether Spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) impairs metabolism in host cells. We generated a cell line HEK293 using pcDNA vector carrying gene expression cassette. A control was empty vector. Gene profiles related metabolic, autophagic, and ferroptotic pathways were investigated. Palmitic acid...
Abstract Background Split-thickness skin graft (STSG) is used frequently, but may result in complications at the donor site. Rapid healing of donor-site wounds critical to relieving morbidity. This study investigated whether autologous cell suspension could improve STSG wounds. Methods Between September 2014 and February 2016, patients requiring STSGs were randomized receive plus hydrocolloid dressings (experimental group) or alone (control for The primary outcome was time complete...
Abstract Background Autologous epidermal basal cell suspension therapy has been proven to be one of the most effective treatments for full-thickness wounds. However, we found there remain obvious defects that significantly confined utilization and function cells (EBCs), especially stem (ESCs) in it. This study investigated whether precoating fibronectin (FN) on wound bed before spraying EBCs could overcome these further explored its possible mechanisms. Methods In vitro study, were isolated...