A5101751622- Micro and Nano Robotics
- Microfluidic and Bio-sensing Technologies
- Cellular Mechanics and Interactions
- Hair Growth and Disorders
- Biomimetic flight and propulsion mechanisms
- Skin and Cellular Biology Research
- Plant Molecular Biology Research
- RNA Research and Splicing
- Pluripotent Stem Cells Research
- Wnt/β-catenin signaling in development and cancer
- Slime Mold and Myxomycetes Research
- CAR-T cell therapy research
- Single-cell and spatial transcriptomics
- Nanoporous metals and alloys
- Gastric Cancer Management and Outcomes
- Modular Robots and Swarm Intelligence
- Magnetic and Electromagnetic Effects
- Electrospun Nanofibers in Biomedical Applications
- Astrophysical Phenomena and Observations
- Cancer Cells and Metastasis
- Mechanics and Biomechanics Studies
- Tissue Engineering and Regenerative Medicine
- Spaceflight effects on biology
- Gene Regulatory Network Analysis
- Protist diversity and phylogeny
Shanghai University
2024
Sun Yat-sen University
2024
University of California, Riverside
2019-2023
Nanchang University
2022-2023
Beijing University of Chinese Medicine
2022
University of California, Irvine
2015-2018
Zhejiang University
2018
University of Minnesota
2012-2015
The control principles behind robust cyclic regeneration of hair follicles (HFs) remain unclear. Using multi-scale modeling, we show that coupling inhibitors and activators with physical growth HFs is sufficient to drive periodicity excitability regeneration. Model simulations experimental data reveal mouse skin behaves as a heterogeneous regenerative field, composed anatomical domains where have distinct cycling dynamics. Interactions between fast-cycling chin ventral slow-cycling dorsal...
This paper explores the continuum fitting method for estimating spin of stellar-mass black holes in X-ray binaries. By thermal emission created by accretion disk to theoretical models, this provides a precise and accessible way estimate holes. Key developments, including use KERRBB SIMPL improve accuracy accounting structure Compton scattering effects. reviews recent applications technique compare it reflection method, noting that is highly accurate with strong emission. also gives new...
A critical event in mammalian embryo development is construction of an inner cell mass surrounded by a trophoectoderm (a shell cells that later form extraembryonic structures). We utilize multi-scale, stochastic modeling to investigate the design principles responsible for robust establishment these structures. This investigation makes three predictions, each supported our quantitative imaging. First, stochasticity expression genes promotes plasticity and has role accurately organizing...
Chimeric antigen receptor (CAR) T-cell based immunotherapy has shown its potential in treating blood cancers, and application to solid tumors is currently being extensively investigated. For glioma brain tumors, various CAR targets include IL13Rα2, EGFRvIII, HER2, EphA2, GD2, B7-H3, chlorotoxin. In this work, we are interested developing a mathematical model of IL13Rα2 targeting T-cells for glioma. We focus on extending the work Kuznetsov et al. (1994) by considering binding multiple single...
During early mammalian embryo development, a small number of cells make robust fate decisions at particular spatial locations in tight time window to form inner cell mass (ICM), and later epiblast (Epi) primitive endoderm (PE). While recent single-cell transcriptomics data allows scrutinization heterogeneity individual cells, consistent temporal mechanisms the utilize robustly Epi/PE layers from ICM remain elusive. Here we build multiscale three-dimensional model for recapitulate observed...
Introduction: Mesenchymal stem cells (MSCs) possess a high degree of self-renewal capacity and in vitro multi-lineage differentiation potential. Decellularized materials have garnered considerable attention due to their elevated biocompatibility, reduced immunogenicity, excellent biodegradability, the ability partially mimic vivo microenvironment conducive cell growth. To address issue mesenchymal losing characteristics during two-dimensional (2D) cultivation, this study established...
A fundamental question in biology is how sharp boundaries of gene expression form precisely spite biological variation/noise. Numerous mechanisms position domains across fields cells (e.g. morphogens), but these are refined remains unclear. In some cases, domain sharpen through differential adhesion-mediated cell sorting. However, can also cellular plasticity, with fate changes driven by up- or down-regulation expression. this context, we have argued that noise help transition to the correct...
Background: The basement membrane (BM) serves as a major barrier to impede tumor cell invasion and extravasation during metastasis. However, the associations between BM-related genes GC remain unclear. Methods: RNA expression data corresponding clinical information of STAD samples were downloaded from TCGA database. We identified subtypes constructed gene prognostic model using lasso-Cox regression analysis. also investigated single-cell properties prognostic-related TME characteristic, TMB...
Objective Ischemic stroke (IS) with subsequent cerebrocardiac syndrome (CCS) has a poor prognosis. We aimed to investigate electrocardiogram (ECG) changes after IS artificial intelligence (AI). Methods collected ECGs from healthy population and patients IS, then analyzed participant demographics ECG parameters identify abnormal features in post-IS ECGs. Next, we trained the convolutional neural network (CNN), random forest (RF) support vector machine (SVM) models automatically detect ECGs;...
Optimal gait design is important for micro-organisms and micro-robots that propel themselves in a fluid environment the absence of external force or torque. The simplest models shape changes are those comprise series linked-spheres can change their separation and/or sizes. We examine dynamics three existing linked-sphere types modeling swimmers low Reynolds number Newtonian fluids using asymptotic analysis, obtain optimal swimming strokes by solving Euler–Lagrange equation shooting method....
Swimming by shape changes at low Reynolds number is widely used in biology andunderstanding how the performance of movement depends on geometric pattern ofshape important to understand swimming microorganisms and designing lowReynolds models. Thesimplest models are those that comprise a series linkedspheres can change their separation and/or size. Herein we comparethe three which these modes different ways.
Flagella and cilia are common features of a wide variety biological cells play important roles in locomotion feeding at the microscale. The beating flagella is controlled by molecular motors that exert forces along length flagellum regulated feedback mechanism coupled to deformation. We develop three-dimensional (3D) model based on sliding-controlled motor feedback, accounting for both bending twist, as well differential resistances orthogonal major plane flagellum. show generated sustained...
Abstract Bencao Tujing ( Illustrated Classic of Materia Medica ) is a brilliant and monumental compendium materia medica by Su Song, which was published in 1061 gathered ancestral knowledge from the Song dynasty as legacy for posterity. The emphasized clinical applications medicinal materials collected nationwide, used illustrated atlases references. descriptions each material subsumed prescriptions containing it were supplemented with relevant medical cases. Medical predating included,...
Recent research has shown that motile cells can adapt their mode of propulsion depending on the environment in which they find themselves. One is swimming by blebbing or other shape changes, and this paper we analyze a class models for movement nano- robots viscous fluid at low Reynolds number. At level individuals, changes comprise volume exchanges between connected spheres control separation, are simple enough significant analytical results be obtained. The goal to understand how...
Cells and microorganisms adopt various strategies to migrate in response different environmental stimuli. To date, many modeling research has focused on the crawling-basedDictyostelium discoideum(Dd) cells migration induced by chemotaxis, yet recent experimental results reveal that even without adhesion or contact a substrate, Dd can still swim follow chemoattractant signals. In this paper, we develop framework investigate chemotaxis amoeboid cell swimming dynamics. A minimal system consists...