A5080087633- Cancer Genomics and Diagnostics
- Renal and related cancers
- Pluripotent Stem Cells Research
- Evolution and Genetic Dynamics
- SARS-CoV-2 and COVID-19 Research
- vaccines and immunoinformatics approaches
- Wnt/β-catenin signaling in development and cancer
- Skin and Cellular Biology Research
- Genomic variations and chromosomal abnormalities
- Hair Growth and Disorders
- CRISPR and Genetic Engineering
- Prenatal Screening and Diagnostics
Yonsei University
2024
Kyungpook National University
2017-2023
Kyungpook National University Hospital
2017
The control principles behind robust cyclic regeneration of hair follicles (HFs) remain unclear. Using multi-scale modeling, we show that coupling inhibitors and activators with physical growth HFs is sufficient to drive periodicity excitability regeneration. Model simulations experimental data reveal mouse skin behaves as a heterogeneous regenerative field, composed anatomical domains where have distinct cycling dynamics. Interactions between fast-cycling chin ventral slow-cycling dorsal...
Abstract Objective The objective of this study is to provide a comparative analysis variant clusters and their relevance across Africa, America, Europe, Asia, in order understand the evolutionary patterns virus different regions inform development targeted interventions genomic surveillance eforts. Methods analyzed global lineage evolution pattern 74, 075 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes from 32 countries four continents, focusing on regions. Variants were...
Summary The trillions of cells that constitute the human body are developed from a fertilized egg through embryogenesis. However, cellular dynamics and developmental outcomes embryonic in humans remain to be largely unknown due technical ethical challenges. Here, we explored whole-genomes 334 single-cell expanded clones targeted deep-sequences 379 bulk tissues obtained various anatomical locations seven individuals. Using discovered 1,688,652 somatic mutations as an intrinsic barcode,...