A5069166240- Cellular Mechanics and Interactions
- Hair Growth and Disorders
- Developmental Biology and Gene Regulation
- Skin and Cellular Biology Research
- Microtubule and mitosis dynamics
- Biocrusts and Microbial Ecology
- Plant Molecular Biology Research
- Wnt/β-catenin signaling in development and cancer
- Tissue Engineering and Regenerative Medicine
Dartmouth College
2021-2022
University of California, Irvine
2017
The control principles behind robust cyclic regeneration of hair follicles (HFs) remain unclear. Using multi-scale modeling, we show that coupling inhibitors and activators with physical growth HFs is sufficient to drive periodicity excitability regeneration. Model simulations experimental data reveal mouse skin behaves as a heterogeneous regenerative field, composed anatomical domains where have distinct cycling dynamics. Interactions between fast-cycling chin ventral slow-cycling dorsal...
ABSTRACT Epithelial folding mediated by apical constriction serves as a fundamental mechanism to convert flat epithelial sheets into multilayered structures. It remains unknown whether additional mechanical inputs are required for constriction-mediated folding. Using Drosophila mesoderm invagination model, we identified an important role the non-constricting, lateral mesodermal cells adjacent domain (‘flanking cells’) in facilitating We found that depletion of basolateral determinant Dlg1...
Abstract Elongation of the body axis through convergent extension is a conserved developmental process that mediated by cell intercalation. During germband epithelium in Drosophila embryos, planar polarized activation non-muscle myosin II (“myosin”) promotes intercalation facilitating patterned remodeling adherens junctions. Here, we report loss basolateral determinant Dlg1 leads to defects subcellular distribution during extension, and consequently, impairs proper junctional apical area...
Abstract Epithelial folding mediated by apical constriction serves as a fundamental mechanism to convert flat epithelial sheets into multilayered structures. It remains elusive whether additional mechanical inputs are required for constriction. Using Drosophila mesoderm invagination model, we identified an important role the non-constricting, lateral mesodermal cells adjacent domain (“flanking cells”) in facilitating folding. We found that depletion of basolateral determinant, Dlg1, disrupts...