A5000756423- Hair Growth and Disorders
- melanin and skin pigmentation
- RNA regulation and disease
- Dermatology and Skin Diseases
- Immune Cell Function and Interaction
- Dermatologic Treatments and Research
- Autoimmune Bullous Skin Diseases
- Skin and Cellular Biology Research
- Genetic and rare skin diseases.
- Nerve injury and regeneration
- T-cell and B-cell Immunology
- Cancer and Skin Lesions
- Wound Healing and Treatments
- Mast cells and histamine
- Cutaneous Melanoma Detection and Management
- Immunotherapy and Immune Responses
- Melanoma and MAPK Pathways
- Contact Dermatitis and Allergies
- Mesenchymal stem cell research
- Hedgehog Signaling Pathway Studies
- Cell Adhesion Molecules Research
- Wnt/β-catenin signaling in development and cancer
- Skin Protection and Aging
- Genomics and Chromatin Dynamics
- Tryptophan and brain disorders
University of British Columbia
2014-2025
University of Bradford
2017-2025
Monasterium Laboratory Skin & Hair Research Solutions (Germany)
2020
Vancouver Coastal Health Research Institute
2006-2017
Vale (Canada)
2015
Vancouver Coastal Health
2012-2015
SKiN Health
2011-2014
The University of Texas Medical Branch at Galveston
2013
University of California, Davis
2013
Philipps University of Marburg
2000-2006
Alopecia areata (AA) is a CD8+ T-cell dependent autoimmune disease of the hair follicle (HF) in which collapse HF immune privilege (IP) plays key role. Mast cells (MCs) are crucial immunomodulatory implicated regulation T cell-dependent immunity, IP, and growth. Therefore, we explored role MCs AA pathogenesis, focusing on MC interactions with T-cells vivo, both human mouse skin lesions. Quantitative (immuno-)histomorphometry revealed that number, degranulation proliferation perifollicular...
Frontal fibrosing alopecia is a distinctive form of scarring presenting with frontal and temporoparietal recession the hairline. Its etiology remains unknown, there are no universal treatment guidelines. We conducted retrospective cohort study to define clinical findings outcomes 62 patients alopecia, one largest cohorts date.Data analysis from case notes was performed on diagnosis seen January 2004 March 2012.Except for male, all in this were females (80% post-menopausal) mostly Caucasians...
Niche signals maintain stem cells in a prolonged quiescence or transiently activate them for proper regeneration1. Altering balanced niche signalling can lead to regenerative disorders. Melanocytic skin nevi human often display excessive hair growth, suggesting cell hyperactivity. Here, using genetic mouse models of nevi2,3, we show that dermal clusters senescent melanocytes drive epithelial exit and change their transcriptome composition, potently enhancing renewal. Nevus distinct...
Alopecia areata (AA) is a T-cell mediated putative autoimmune disease of hair follicles, which can be transferred by CD4(+) T cells. However, whether T-helper (Th) 1 or Th2 cytokines are predominant has not yet been defined.To elucidate the importance Th1 cells in pathogenesis AA we investigated functional role interferon (IFN)-gamma experimental induction AA.AA was experimentally induced grafting full-thickness skin from AA-affected C3H/HeJ mice on to with targeted deletion cytokine...
Alopecia areata (AA) is a nonscarring, inflammatory skin disease that results in patchy hair loss. AA unpredictable its onset, severity, and duration making it potentially very stressful for affected individuals. Currently, the treatment options are limited efficacy of these treatments varies from patient to patient. The exact etiology unknown. This article provides some insights into etiopathogenesis why people develop it. current knowledge on pathogenesis summarized recent hypotheses...