A5031861915- Hair Growth and Disorders
- Dermatology and Skin Diseases
- Immune Cell Function and Interaction
- melanin and skin pigmentation
- Skin Protection and Aging
- Dermatologic Treatments and Research
- RNA regulation and disease
- T-cell and B-cell Immunology
- Skin and Cellular Biology Research
- Wound Healing and Treatments
- Olfactory and Sensory Function Studies
- Mesenchymal stem cell research
- Autoimmune Bullous Skin Diseases
- Nerve injury and regeneration
- IL-33, ST2, and ILC Pathways
- Mast cells and histamine
- Urticaria and Related Conditions
- Hidradenitis Suppurativa and Treatments
- Immunotherapy and Immune Responses
- dental development and anomalies
- Acne and Rosacea Treatments and Effects
- Peroxisome Proliferator-Activated Receptors
- Immune cells in cancer
- Chemotherapy-related skin toxicity
- NF-κB Signaling Pathways
Monasterium Laboratory Skin & Hair Research Solutions (Germany)
2016-2025
University of Münster
2014-2023
University of Miami
2019
University of Manchester
2019
Textile Research Institute
2019
University of Bradford
2019
CTO Hospital
2015
University of Lübeck
2011-2014
University of California, Davis
2006
Rutgers, The State University of New Jersey
1994-1995
Alopecia areata (AA) is a CD8+ T-cell dependent autoimmune disease of the hair follicle (HF) in which collapse HF immune privilege (IP) plays key role. Mast cells (MCs) are crucial immunomodulatory implicated regulation T cell-dependent immunity, IP, and growth. Therefore, we explored role MCs AA pathogenesis, focusing on MC interactions with T-cells vivo, both human mouse skin lesions. Quantitative (immuno-)histomorphometry revealed that number, degranulation proliferation perifollicular...
Olfactory receptors are expressed by different cell types throughout the body and regulate physiological functions beyond olfaction. In particular, olfactory receptor OR2AT4 has been shown to stimulate keratinocyte proliferation in skin. Here, we show that epithelium of human hair follicles, particularly outer root sheath, expresses OR2AT4, specific stimulation a synthetic sandalwood odorant (Sandalore®) prolongs growth ex vivo decreasing apoptosis increasing production anagen-prolonging...
Autophagy plays a crucial role in health and disease, regulating central cellular processes such as adaptive stress responses, differentiation, tissue development, homeostasis. However, the of autophagy human physiology is poorly understood, highlighting need for model organ system to assess efficacy safety strategies therapeutically modulate autophagy. As complete, cyclically remodelled (mini-)organ, culture scalp hair follicles (HFs), which, after massive growth (anagen), spontaneously...
Although the effect of ultraviolet radiation (UVR) on human skin has been extensively studied, very little is known how UVR impacts hair follicle (HF) homeostasis. Here, we investigated solar spectrum that hits surface HF biology, and whether any detrimental effects can be mitigated by a widely used cosmetic nutraceutical ingredient, caffeine.Human scalp with terminal HFs was irradiated transepidermally ex vivo using either 10 J/cm2 UVA (340-440 nm) + 20 mJ/cm2 UVB (290-320 (low dose) or 50...
Transplanting aged human skin onto young SCID/beige mice morphologically rejuvenates the xenotransplants. This is accompanied by angiogenesis, epidermal repigmentation, and substantial improvements in key aging-associated biomarkers, including ß-galactosidase, p16ink4a, SIRT1, PGC1α, collagen 17A, MMP1. Angiogenesis- hypoxia-related pathways, namely, vascular endothelial growth factor A (VEGF-A) HIF1A, are most up-regulated rejuvenated skin. rejuvenation cascade, which can be prevented...
Despite recent advances in our understanding of the pathogenesis ectodermal dysplasias (EDs), molecular basis many these disorders remains unknown. In present study, we aimed at elucidating genetic a new form ED featuring facial dysmorphism, scalp hypotrichosis and hypodontia. Using whole exome sequencing, identified 2 frameshift missense mutations TSPEAR segregating with disease phenotype 3 families. encodes thrombospondin-type laminin G domain EAR repeats (TSPEAR) protein, whose function...
Alopecia areata (AA) is an autoimmune disorder whose pathogenesis involves the collapse of relative immune privilege (IP) hair follicle (HF). Given that vasoactive intestinal peptide (VIP) immunoinhibitory neuropeptide released by perifollicular sensory nerve fibres, which play a role in IP maintenance, it may modulate human HF-IP and thus be therapeutically relevant for AA.To answer following questions: Do HFs express VIP receptors, does their stimulation protect from or restore...
Alopecia areata (AA) is a hair loss disorder resulting from an autoimmune reaction against follicles. T-helper 1 cells are major contributor to this disorder, but little known about the role of T-regulatory (Tregs) in AA. Here, we analysed distribution circulating Treg subsets twenty AA patients with active and fifteen healthy subjects by flow cytometry. The suppressor HLA-DR+ subpopulation was significantly reduced (P<0.001) there were fewer expressing CD39 among CD4+CD25+Foxp3+ (P =...
Permanent chemotherapy-induced alopecia (pCIA), for which preventive interventions remain limited, can manifest with scarring. While the underlying pathomechanisms of pCIA are unclear, depletion epithelial hair follicle (HF) stem cells (eHFSCs) is likely to play a role.To explore hypothesis that, besides apoptosis, eHFSCs undergo pathological epithelial-mesenchymal transition (EMT) in pCIA, thus explaining scarring phenotype. Furthermore, we tested whether peroxisome proliferator-activated...
ABSTRACT Epidermal melanocytes form synaptic‐like contacts with cutaneous nerve fibers, but the functional outcome of these connections remains elusive. In this pilot study we used our fully humanized re‐innervated skin organ culture model to investigate melanocyte‐nerve fiber interactions in UV‐B‐induced melanogenesis. UV‐B‐irradiation significantly enhanced melanin content and tyrosinase activity compared non‐innervated controls, indicating that neuronal presence is essential for...
Here, we have explored the involvement of innate lymphoid cells-type 1 (ILC1) in pathogenesis alopecia areata (AA), because found them to be significantly increased around lesional and non-lesional HFs AA patients. To further explore these unexpected findings, first co-cultured autologous circulating ILC1-like cells (ILC1lc) with healthy, but stressed, organ-cultured human scalp hair follicles (HFs). ILClc induced all hallmarks ex vivo: they promoted premature, apoptosis-driven HF regression...
Inhibition of IL-4/IL-13 signaling has dramatically improved the treatment atopic dermatitis (AD). In many patients, however, clinical responses are slow to develop and remain modest. Indeed, some symptoms AD dependent on IL-31, which is only partially reduced by inhibition. Thus, there an unmet need for treatments that concomitantly block IL-31 pathways. We engineered NM26-2198, a bispecific tetravalent antibody designed accomplish this task. reporter cell lines, NM26-2198 inhibited with...