Alexandre Simonin

ORCID: 0009-0009-3022-8974
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About
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Research Areas
  • Asthma and respiratory diseases
  • Allergic Rhinitis and Sensitization
  • Dermatology and Skin Diseases

NBE Therapeutics (Switzerland)
2024

Inhibition of IL-4/IL-13 signaling has dramatically improved the treatment atopic dermatitis (AD). In many patients, however, clinical responses are slow to develop and remain modest. Indeed, some symptoms AD dependent on IL-31, which is only partially reduced by inhibition. Thus, there an unmet need for treatments that concomitantly block IL-31 pathways. We engineered NM26-2198, a bispecific tetravalent antibody designed accomplish this task. reporter cell lines, NM26-2198 inhibited with...

10.1016/j.xjidi.2024.100258 article EN cc-by-nc-nd JID Innovations 2024-01-16
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