A5044150025- Circadian rhythm and melatonin
- Asthma and respiratory diseases
- Hair Growth and Disorders
- Psoriasis: Treatment and Pathogenesis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Inflammasome and immune disorders
- melanin and skin pigmentation
- Skin Protection and Aging
- Antifungal resistance and susceptibility
- Vasculitis and related conditions
- Health Sciences Research and Education
- IL-33, ST2, and ILC Pathways
- Inflammatory mediators and NSAID effects
- Health and Medical Research Impacts
- Dermatology and Skin Diseases
- Mesenchymal stem cell research
- Heme Oxygenase-1 and Carbon Monoxide
University of California, Irvine
2018-2023
Gasdermin-D (GSDMD) in inflammasome-activated macrophages is cleaved by caspase-1 to generate N-GSDMD fragments. then oligomerizes the plasma membrane (PM) form pores that increase permeability, leading pyroptosis and IL-1β release. In contrast, we report although required for secretion NLRP3-activated human murine neutrophils, does not localize PM or permeability pyroptosis. Instead, biochemical microscopy studies reveal neutrophils predominantly associates with azurophilic granules LC3+...
Niche signals maintain stem cells in a prolonged quiescence or transiently activate them for proper regeneration1. Altering balanced niche signalling can lead to regenerative disorders. Melanocytic skin nevi human often display excessive hair growth, suggesting cell hyperactivity. Here, using genetic mouse models of nevi2,3, we show that dermal clusters senescent melanocytes drive epithelial exit and change their transcriptome composition, potently enhancing renewal. Nevus distinct...
The circadian clock coordinates a variety of immune responses with signals from the external environment to promote survival. We investigated potential reciprocal relationship between and skin inflammation. treated mice topically Toll-like receptor 7 (TLR7) agonist imiquimod (IMQ) activate IFN-sensitive gene (ISG) pathways induce psoriasiform IMQ transiently altered core expression, an effect mirrored in human patient psoriatic lesions. In mouse 1 d after treatment, ISGs, including key ISG...
Neutrophil extracellular trap (NET) formation requires chromatin decondensation prior to nuclear swelling and eventual release of DNA, which occurs together with cytoplasmic anti-microbial proteins. A key mediator is protein deiminase 4 (PAD4), catalyzes histone citrullination. In the current study, we examined role PAD4 NETosis following activation neutrophils by A. fumigatus hyphal extracts or cell wall β-glucan (curdlan), found that both induced NET human murine neutrophils. Also, using...