A5101927342- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Medical Imaging and Analysis
- Hip and Femur Fractures
- Intracerebral and Subarachnoid Hemorrhage Research
- Climate Change and Health Impacts
- Glioma Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Sinusitis and nasal conditions
- Air Quality and Health Impacts
- Head and Neck Surgical Oncology
- Cardiac, Anesthesia and Surgical Outcomes
- Infectious Diseases and Tuberculosis
- Vascular Malformations Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Enhanced Recovery After Surgery
- Amoebic Infections and Treatments
- Nutrition and Health in Aging
- Meningioma and schwannoma management
- Management of metastatic bone disease
- Cardiac electrophysiology and arrhythmias
- SARS-CoV-2 and COVID-19 Research
- Fetal and Pediatric Neurological Disorders
- Otolaryngology and Infectious Diseases
- Spinal Dysraphism and Malformations
The First Affiliated Hospital, Sun Yat-sen University
2025
Sun Yat-sen University
2012-2025
Sichuan University
2010-2025
Capital Medical University
2014-2024
Chengdu Fifth People's Hospital
2020-2023
West China Hospital of Sichuan University
2010-2023
Chengdu University of Traditional Chinese Medicine
2022-2023
Chengdu University
2020-2022
Xiangya Hospital Central South University
2020
Beijing Sanbo Brain Hospital
2020
Abstract The coronavirus disease-19 (COVID-19) caused by SARS-CoV-2 infection can lead to a series of clinical settings from non-symptomatic viral carriers/spreaders severe illness characterized acute respiratory distress syndrome (ARDS)1,2. A sizable part patients with COVID-19 have mild symptoms at the early stage infection, but disease progression may become quite rapid in later ARDS as common manifestation and followed critical multiple organ failure, causing high mortality rate 7-10%...
The coronavirus disease 19 (COVID-19) pandemic has brought a great threat to global public health. Currently, mounting evidence shown the occurrence of neurological symptoms in patients with COVID-19. However, detailed mechanism by which SARS-CoV-2 attacks brain is not well characterized. Recent investigations have revealed that cytokine storm contributes inflammation and subsequently triggers manifestations during COVID-19 outbreak. Targeting may provide significant clues treatment...
Diabetic wound healing remains a significant clinical challenge because of hyperglycaemia-induced cellular senescence, impaired angiogenesis, and chronic inflammation. To address these issues, we developed multifunctional hydrogel (GelMA/PNS/Alg@IGF-1) that integrates gelatine methacryloyl (GelMA), Panax notoginseng saponins (PNS), sodium alginate microspheres encapsulating insulin-like growth factor-1 (IGF-1). This was engineered to achieve gradient sustained release bioactive agents target...
Peritumoral brain edema is a common complication of meningiomas. It believed that vascular endothelial growth factor (VEGF), as an angiogenic factor, plays vital role in formation. Aquaporin-4 (AQP4) small integral membrane protein regulates water the normal brain. However, expression AQP4 and its relationship to VEGF edematous meningiomas are not well known. We studied tumor specimens 59 human supratentorial Western blot analysis was used detect AQP4, double-labeling immunofluorescence...
Frailty is an independent predictor of mortality and adverse events (AEs) in patients undergoing surgery. This study aimed to quantify the ability Modified Index (mFI) predict AEs older elective posterior thoracolumbar fusion surgery.We retrospectively reviewed results 426 with following diagnoses follow-up evaluations at least 12 months duration: lumbar disc herniation, 125; degenerative spondylolisthesis, 81; spinal canal stenosis, 187; adult deformities, 33. The cases were divided into...
The benefits of the enhanced recovery after surgery (ERAS) program to elderly patients have not been evaluated in lumbar fusion surgery. Compliance with ERAS is associated prognosis. There currently no adequate assessment about importance individual components aim study was analyze effect compliance our and relative among undergoing surgery.A retrospective case-review conducted from March 2018 2020. for at department implemented. Overall found be 92.9%, this used as a cutoff dividing into...
Abstract Study design Retrospective cohort study. Purpose The aim of our study was to determine the rates and indications reoperations following primary lumbar fusion, as well independent risk factors for early late reoperation. Methods We retrospectively reviewed patients who underwent fusion surgery between January 2017 March 2020. All were followed up more than 2 years. Characteristics, laboratory tests, diagnosis surgery-related variables compared among reoperation (< 3 months), (>...
Although there is much controversy over the use of methylprednisolone (MP), it one main drugs used in treatment acute spinal cord injury (SCI). The induction proliferation and differentiation endogenous neural progenitor cells (NPCs) considered a promising mode for SCI. However, effects MP on cord-derived NPCs low oxygen enviroment remain to be delineated. Thus, aim this study was investigate potential cultured under conditions vitro elucidate molecular mechanisms involved. Fetal rat were...
Cerebral sparganosis is a rare parasitic disease of thecentral nervous system that caused by sparganum.Cerebral occurs worldwide, but it foundmore frequently in China, Japan, and Southeastern Asia (1-2). Sparganum, the second-stage larva Spirometra mansoni,can produce chronic active inflammation through slowmigration brain (1). They can also parasitize othersites human body, such as subcutaneous tissue,body cavities eyes, survive for 5-20 years (3).In this paper, we report case cerebral...
Objective This study aimed to identify the risk factors for vertebral compression fractures in patients with osteoporosis. Methods A total of 864 osteoporosis were enrolled a retrospective from February 2010 June 2016. Patients diseases, such as pathological fractures, high-energy direct injury thoracic or lumbar vertebrae, and severe spinal deformity, excluded. The divided into two groups: those (288) no (576). Information on patients' age, sex, bone mineral density (BMD), trauma, body mass...
Objective To estimate the prevalence of psoriasis in resident population Hainan province through a large-scale,multi-center epidemiological survey.Methods Ten small towns or communities were selected from each 18 cities counties as survey sites.Multi-stage sampling strategies (including stratified sampling,simple random and cluster sampling) used this study.After respondents signed an informed consent form,investigators completed registration form containing information regarding clinical...
Objective : Pineal region tumors (PRTs) are uncommon, and treatments vary among neoplasm types. The authors report their experience with gamma knife surgery (GKS) as an initial treatment in a series of PRT patients unclear pathological diagnoses. Method Seventeen negative pathology who underwent GKS were retrospectively studied. Nine had further whole-brain spinal cord radiotherapy chemotherapy 6–9 months after GKS. Results Sixteen 17 cases followed up over mean 33.3 months. total response...
Background Lumbar drainage is widely used in the clinic; however, forecasting lumbar drainage-related meningitis (LDRM) limited. We aimed to establish prediction models using supervised machine learning (ML) algorithms. Methods utilized a cohort of 273 eligible cases. Data were preprocessed and split into training testing sets. Optimal hyper-parameters archived by 10-fold cross-validation grid search. The support vector (SVM), random forest (RF), artificial neural network (ANN) adopted for...
The correlation between meteorological parameters and intracerebral hemorrhage (ICH) occurrence is controversial. Our research explored the effect of daily on ICH risk in a subtropical monsoon basin climate.We retrospectively analyzed patients with teaching hospital. Daily including temperature (TEM), atmospheric pressure (PRE), relative humidity (RHU), sunshine duration (SSD) were collected, diurnal variation (daily maximum minus minimum) day-to-day (average day previous day) calculated to...
Purpose: To investigate the role of Mini Nutritional Assessment-Short Form (MNA-SF) in predicting postoperative complications older patients (≥ 75 years) undergoing lumbar fusion surgery. Patients and Methods: who had undergone posterior surgery between June 2019 September 2021 were enrolled. Those with an MNA-SF score 12 or higher categorized as Nourished group, while those a less than placed Malnutrition-Risk group. Preoperative, intraoperative, variables groups compared. then...
Short-term air pollution exposure and intracerebral hemorrhage (ICH) risk are related. However, the impact of pollutant levels decline on this relationship, which attributes to clean policy implementation COVID-19 pandemic lockdown, is unclear. In present research, we explored influence different ICH during eight years in a southwestern China megacity.Our research used time-stratified case-crossover design. We retrospectively analyzed patients teaching hospital from January 1, 2014, December...