A5050579675- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Hepatitis B Virus Studies
- Spinal Cord Injury Research
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Management of metastatic bone disease
- Circular RNAs in diseases
- Cutaneous Melanoma Detection and Management
- RNA modifications and cancer
- Bone and Joint Diseases
- Liver Disease and Transplantation
- Nonmelanoma Skin Cancer Studies
- Ferroptosis and cancer prognosis
- Sarcoma Diagnosis and Treatment
- Spondyloarthritis Studies and Treatments
- Reconstructive Surgery and Microvascular Techniques
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Autoimmune Bullous Skin Diseases
- Virus-based gene therapy research
- NF-κB Signaling Pathways
- Bone health and treatments
- Cancer Mechanisms and Therapy
Sun Yat-sen University
2016-2025
Guangzhou Eighth People's Hospital
2012-2025
Guangzhou Medical University
2020-2025
Sun Yat-sen Memorial Hospital
2013-2024
Hangzhou Normal University
2024
Eighth Affiliated Hospital of Sun Yat-sen University
2019-2023
University of Glasgow
2022
The Eighth Hospital of Xi'an
2022
Nanjing Forestry University
2022
Sir Run Run Shaw Hospital
2013-2021
Abstract Introduction Ankylosing spondylitis (AS) is a chronic autoimmune disease, and the precise pathogenesis largely unknown at present. Bone marrow-derived mesenchymal stem cells (BMSCs) with immunosuppressive anti-inflammatory potential Th17/Treg reciprocal relationship regulated by BMSCs have been reported to be involved in some disorders. Here we studied biological immunological characteristics of BMSCs, frequency phenotype CCR4 + CCR6 Th/Treg their interaction vitro AS. Methods The...
Background Spinal cord injuries are highly disabling and deadly injuries. Currently, few studies focus on non-traumatic spinal injuries, there is little information regarding the risk factors for complete This study aims to describe demographics injury characteristics both traumatic explore Methods A retrospective was performed by reviewing medical records of 3,832 patients with who were first admitted sampled hospitals in Guangdong, China. The described compared between different groups...
A new class of white luminescent materials, white-light-emitting graphene quantum dots (WGQDs), have attracted increasing attention because their unique features and potential applications.
Spinal cord injury (SCI) often causes severe functional impairment of body, which leads to a huge burden the patient and whole society. Many strategies, especially biomaterials, have been employed for SCI repair. Among various injectable hydrogels attracted much attention because their ability load components be injected into lesioned area without surgeries. In this review, we summarize recent progress in We firstly introduce pathophysiology SCI, reveals mechanism clinical manifestations...
Our objective was to evaluate the feasibility, safety, and efficacy of intravenous (IV) infusion allogenic mesenchymal stem cells (MSCs) in ankylosing spondylitis (AS) patients who are refractory or cannot tolerate side effects nonsteroidal anti-inflammatory drugs (NSAIDs). AS enrolled this study received four IV infusions MSCs on days 0, 7, 14, 21. The percentage ASAS20 responders (the primary endpoint) at fourth week mean response duration secondary were used assess treatment MSC...
The control of self-renewal and differentiation neural stem progenitor cells is a crucial issue in cell cancer biology. Drosophila type II neuroblast lineages are prone to developing impaired homeostasis if the limited self-renewing potential intermediate progenitors (INPs) unrestrained. Here, we demonstrate that SWI/SNF chromatin remodeling Brahma (Brm) complex functions cooperatively with another factor, Histone deacetylase 3 (HDAC3) suppress formation ectopic neuroblasts. We show multiple...
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide. The T cell receptor (TCR) and B (BCR) are receptors on surface or cell, which crucial for recognizing tumor antigens. It profound to establish a practical TCR/BCR-related gene signature prognostic model further diagnosis treatment among HCC patients. In this study, we categorized expression data patients from Cancer Genome Altas identified TCR related genes by Least Absolute Shrinkage Selection...
SUMMARY This retrospective study was conducted to assess and compare the diagnostic accuracy between referring general practitioners dermatologists with regard skin conditions. Six hundred fifty‐six consecutive practitioner referrals a private dermatology practice outpatient department were assessed. The concordance rate in diagnoses from wide spectrum of dermatological diseases compared dermatologists. Referring agreed dermatologists’ clinical diagnosis histology (when available) 42% cases....
Study Design. A hospital-based retrospective epidemiological study. Objective. The aim of this study was to examine the demographic and characteristics patients with traumatic spinal cord injury (TSCI) in Guangdong help health-related institutions develop measures determine best allocation medical resources. Summary Background Data. TSCI is a highly disabling deadly injury. Currently, there little information regarding for Guangdong. Methods. We retrospectively reviewed records partial...
Although many staging classifications have been proposed for hepatocellular carcinoma (HCC), determining a patient's prognosis in clinical practice is challenge due to the molecular diversity of HCC. We investigated relationship between MEP1A, candidate oncogene, and outcomes HCC patients; furthermore, we explored role MEP1A In this report, it was demonstrated by quantitative real‐time polymerase chain reaction that messenger RNA levels were significantly elevated tumor tissues compared with...
Non-small cell lung cancer (NSCLC) stands prominent among the prevailing and formidable oncological entities. The immune metabolic-related molecule Phospholipase A2, group IID (PLA2G2D) exerts promotional effects on tumor progression. However, its involvement in angiogenesis remains elusive. Therefore, this investigation delved into functional significance of PLA2G2D concerning NSCLC. This study analyzed expression enriched pathways NSCLC tissues through bioinformatics analysis, measured...
This study aimed to investigate the effect of residential exposure green space on incident osteoporosis and further explore modification genetic susceptibility.
ABSTRACT: Aim: The slit diaphragm (SD) of podocyte impairment contributes to massive proteinuria and progressive glomerulosclerosis in many human glomerular diseases. aim the study was determine if thiazolidinedione (TZD) reduce focal segmental (FSGS) by preserving structure function SD. Methods: Adriamycin‐induced FSGS rat models were employed. Urinary protein content measured dynamically during experiment. Additional biochemical parameters serum samples after animals killed. Glomerular...
OBJECTIVE The aim of this work was to investigate the effects methylprednisolone on proliferation endogenous neural stem cells (ENSCs) in nonhuman primates with spinal cord injury (SCI). METHODS A total 14 healthy cynomolgus monkeys ( Macaca fascicularis ) (4–5 years age) were randomly divided into 3 groups: control group (n = 6), SCI and therapy 2). Only laminectomy performed animals at T-10. induced using Allen’s weight-drop method (50 mm × 50 g) injure posterior portion In group,...
Accurate assessment of breast volume is an essential component preoperative planning in one-stage immediate reconstruction (IBR) for achieving symmetry and a satisfactory cosmetic outcome. In this study, we compared estimation using three-dimensional (3D) surface imaging with magnetic resonance (MRI) to determine the accuracy measurements. Further, 3D printing mold facilitating autologous intraoperatively described.Patients scheduled therapeutic or prophylactic mastectomy IBR, either by...
Osteosarcoma (OS) patients with lung metastasis have poor prognoses, and effective therapeutic strategies for delaying or inhibiting the spread of from primary OS site are lacking. Hence, it is critical to elucidate underlying mechanisms identify additional new treatment patients.Differential expression functional analyses were performed key genes relevant signaling pathways associated metastasis. The CCR9 in cell lines tissues was measured by RT-qPCR, western blotting immunohistochemistry....
SUMMARY A dual‐centre, randomized, double‐blind, vehicle‐controlled study was conducted to evaluate the safety and efficacy of short courses therapy with imiquimod 5% cream in clearing ≥75% baseline solar keratoses (SK) within a field treatment. Subjects 5–15 SK one treatment area (scalp, forehead temples, or both cheeks) were randomized apply vehicle entire three times week for 3 weeks. assessed 4 weeks after completing first course clearance lesions. <75% commenced on second 3‐week...
Death-associated protein kinase 1 (DAPK1) is a key that mediates neuronal death in ischemic stroke. Although the substrates of DAPK1 and molecular signal stroke have been gradually discovered, modulation itself still unclear. Here we first reveal Caytaxin, brain-specific member BCL2/adenovirus E1B -interacting (BNIP-2), increases interacts with as early 2 h after middle cerebral artery occlusion (MCAO) penumbra area mouse brain. Furthermore, Caytaxin binds to at presynaptic site inhibits...
The pathogenesis of dysfunctional immunoregulation mesenchymal stem cells (MSCs) in ankylosing spondylitis (AS) is thought to be a complex process that involves multiple genetic alterations. In this study, MSCs derived from both healthy donors and AS patients were cultured normal media or mimicking an inflammatory environment. Whole genome expression profiling analysis 33,351 genes was performed differentially expressed related analyzed by GO term KEGG pathway analysis. Our results showed...