Abstract Background The optimal strategy for adjuvant therapy after curative resection hepatocellular carcinoma (HCC) patients with solitary tumor and microvascular invasion (MVI) is controversial. This trial evaluated the efficacy safety of transcatheter arterial chemoembolization (TACE) hepatectomy versus alone in HCC a ≥ 5 cm MVI. Methods In this randomized, open‐labeled, phase III trial, MVI were randomly assigned (1:1) to receive either 1–2 cycles TACE (Hepatectomy‐TACE) or (Hepatectomy...

Abstract Background & Aims The lymphocyte‐C‐reactive protein ratio (LCR) is a novel inflammatory‐based score, based solely on the lymphocyte and C‐reactive protein. We aimed to clarify prognostic value of LCR score in intrahepatic cholangiocarcinoma (ICC) patients after resection. Methods compared accuracy with other scores this large, multicentre cohort study. independent variables associated overall survival (OS) were explored both primary (n = 228) validation cohorts 135). Harrell's...

The optimal treatment strategy for recurrent hepatocellular carcinoma (HCC) remains unclear. Therefore, we aimed to compare the outcomes of repeat hepatic resection (RHR) and radiofrequency ablation (RFA) HCC.From December 2004 2015, 138 patients who underwent RHR 194 RFA were enrolled. Propensity score matching (PSM) was performed establish 1:1 RHR-RFA group matching. Clinical compared before after matching.Before matching, 1-, 3-, 5-year postrecurrence survival (PRS) rates 91.8%, 82.0%,...

We have previously reported that Cezanne could be a prognostic biomarker for survival in hepatocellular carcinoma (HCC) patients. However, the role of genes HCC cells and its response to postoperative adjuvant transcatheter arterial chemoembolization (TACE) patients remains unknown. In this study, expression was detected human using real-time PCR, western blot immunohistochemistry. The function determined by Transwell invasion assays nude mice metastasis assay. who received TACE after...

// Jia-hong Wang 1, * , Wei Jing Xu 2 Zhi-xing Guo 3 Cheng-zuo Xiao 1 Yong-fa Zhang Pei-en Jian Xiao-liang Wu Ming Shi Rong-ping Department of Hepatobilliary Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory Oncology in South China, Collaborative Innovation Center for Medicine, Guangzhou, China Ultrasonics, These authors have contributed equally to this work Correspondence to: Rong-Ping Guo, e-mail: guorp@sysucc.org.cn Keywords: hepatocellular carcinoma, Cripto-1, MMP-9,...

Although many staging classifications have been proposed for hepatocellular carcinoma (HCC), determining a patient's prognosis in clinical practice is challenge due to the molecular diversity of HCC. We investigated relationship between MEP1A, candidate oncogene, and outcomes HCC patients; furthermore, we explored role MEP1A In this report, it was demonstrated by quantitative real‐time polymerase chain reaction that messenger RNA levels were significantly elevated tumor tissues compared with...

Background and aimsThe liver function reserve in Child-Pugh (C-P) grade A hepatocellular carcinoma (HCC) patients varies widely, the value of platelet-albumin-bilirubin (PALBI) predicting posthepatectomy failure (PHLF) B/C overall survival (OS) remains unknown.MethodsFrom Dec 2004 to 2013, 2038 C-P HCC after resection were enrolled. Univariate multivariate analyses performed clarify risk factors for PHLF OS.ResultsThe PALBI had higher area under curve values than albumin-bilirubin (ALBI)...

Background: The benefits of anatomical resection (AR) and non-anatomical (NAR) on hepatocellular carcinoma (HCC) patients with microscope vascular invasion (MVI) remain unknown. We aimed to investigate the prognostic outcomes AR NAR for HCC MVI. Study Design: A total 362 consecutive diagnosed MVI after hepatic between February 2005 December 2013 were included in this study. patient compared, a 1:2 propensity score matching (PSM) analysis was applied eliminate selection bias. Results: Before...

Hepatocellular carcinoma (HCC) is among the most fatal types of cancer worldwide due to its high rates recurrence and metastasis. The molecular processes involved in HCC progression require further investigation identify biomarkers for use diagnosis treatment. In present study, significance prognostic value matrix metallopeptidase 12 (MMP12) expression human was investigated. MMP12 mRNA investigated using reverse transcription-quantitative polymerase chain reaction analysis 42 pairs tumor...

The optimal surgical resection method for hepatocellular carcinoma (HCC) patients with portal vein tumor thrombus (PVTT) that maximizes both safety and long-term outcome has not yet been determined. aim of this study was to compare the clinical outcomes following peeling off versus en bloc PVTT.From 2005 2012, 252 HCC type I/II PVTT who underwent hepatic were divided into two groups according whether they received (n = 113) or 139). compared before after propensity score matching.The model...

The subgroups of patients with intermediate-stage (BCLC-B) hepatocellular carcinoma (HCC) who would truly benefit from hepatic resection (HR) are unknown. An objective point score was established to guide the selection these for HR. In all, 255 consecutive HCC treated HR were evaluated retrospectively and included in this study (the training cohort). variables on overall survival (OS, log-rank test) investigated a NSP score) developed by using Cox-regression model validated an independent...

To compare the outcomes of hepatic resection and transcatheter arterial chemoembolization for resectable hepatocellular carcinoma with vein tumor thrombus. From January 2006 to November 2013, 28 patients initially diagnosed combined thrombus received resection. These were compared 56 case-matched controls (1:2 ratio) selected from a pool 91 who as an initial treatment during same period. Clinical characteristics, adverse events, overall survival survival-related factors analyzed. The 1-, 2-...

Objective: To compare the treatment outcomes of sorafenib plus transarterial chemoembolization (TACE) vs TACE alone in patients with hepatocellular carcinoma (HCC) and hepatic vein tumor thrombus (HVTT). Methods: Twenty who were initially diagnosed HCC HVTT received combined during February 2009 to October 2013 included study. minimize selection bias, these compared 60 case-matched controls selected from a pool 81 (in 1:3 ratio) same period. The primary end point was overall survival (OS)....

Most patients with hepatocellular carcinoma (HCC) are not candidates for liver resection. We investigated the clinicopathological characteristics and prognosis of initially unresectable HCC who underwent hepatectomy after conversion therapy hepatic arterial infusion chemotherapy (HAIC), tyrosine kinase inhibitors (TKIs), anti-PD-1 antibodies.Patients received HAIC combined TKIs antibodies followed by between December 2020 2022, were retrospectively analyzed. Patient characteristics, tumor...

The clinical significance of the sodium-potassium ATPase regulator FXYD domain-containing ion transport 3 (FXYD3) has been demonstrated in a number types cancer. However, role this protein human hepatocellular carcinoma (HCC) remains to be elucidated. In present study, 217 HCC tissue samples were analyzed evaluate expression and prognostic FXYD3 HCC. Reverse transcription-quantitative polymerase chain reaction was used analyze mRNA 80 primary specimens paired non-cancerous liver samples,...

This study aimed to evaluate the prognostic value of lymphocyte-C-reactive protein ratio (LCR) score, a novel inflammation-based score based on lymphocytes and C-reactive protein, in hepatocellular carcinoma (HCC) patients treated with curative intent.A total 1158 HCC undergoing surgical resection or radiofrequency ablation intent were recruited from 3 different centres divided into primary cohort (n=716) validation (n=442). Univariate multivariate analyses performed identify variables...

Introduction: EGF, latrophilin, and seven transmembrane domain containing 1 (ELTD1) constitutes an orphan G-protein-coupled receptor (GPCR) of the adhesion family. High expression ELTD1 is correlated with favorable prognosis hepatocellular carcinoma (HCC). After silencing expression, however, tumor invasiveness drastically reduced. The underlying mechanism this apparent contradictory phenomenon unknown. Because GPCRs couple extracellular to intracellular signaling, as a member family,...

Background: The combination of tyrosine kinase inhibitors (TKIs) and anti-PD-1 antibodies with hepatic arterial infusion chemotherapy (HAIC) or transarterial chemoembolization (TACE) has shown encouraging anti-tumor effects in the treatment hepatocellular carcinoma (HCC). We explored efficacy safety TKIs combined HAIC TACE HCC. Methods: Data from 302 HCC patients receiving (HAIC-TP group) 446 (TACE-TP were retrospectively collected. Clinicopathological characteristics, tumor response,...

RNA-binding motif protein 25 (RBM25) is a poorly characterized that involved in several biological processes and regulates the proliferation metastasis of tumor cells. The regulatory role RBM25 hepatocellular carcinoma (HCC) unknown. Here, expression outcomes HCC patients were evaluated using Cancer Genome Atlas database. was overexpressed compared with healthy group. high tissues significantly related to poor overall survival (P<0.001). Overexpression contributed poorer male N0 stage...