A5100390316- Inhalation and Respiratory Drug Delivery
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Lung Cancer Diagnosis and Treatment
- Advanced Drug Delivery Systems
- Extracellular vesicles in disease
- Ferroptosis and cancer prognosis
- Protein Interaction Studies and Fluorescence Analysis
- Advancements in Transdermal Drug Delivery
- Surfactants and Colloidal Systems
- Esophageal Cancer Research and Treatment
- Spine and Intervertebral Disc Pathology
- Solar-Powered Water Purification Methods
- Antimicrobial Peptides and Activities
- Spinal Fractures and Fixation Techniques
- Pleural and Pulmonary Diseases
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Optical Wireless Communication Technologies
- Aquaculture Nutrition and Growth
- Solar Thermal and Photovoltaic Systems
- Drug Solubulity and Delivery Systems
- Head and Neck Surgical Oncology
- Photodynamic Therapy Research Studies
- Thermodynamic properties of mixtures
Sichuan University
2025
Sun Yat-sen University
2014-2024
Soochow University
2022-2024
PLA Rocket Force University of Engineering
2024
Nanjing Forestry University
2021-2024
Nanjing University of Science and Technology
2024
Xian Central Hospital
2024
East China Normal University
2024
Shanghai Sixth People's Hospital
2024
Anhui University
2024
Although certain therapeutic agents with immunogenic properties may enhance antitumor immunity, cancer cells can eliminate harmful cytoplasmic entities and escape immunosurveillance by orchestrating autophagy. Here, an ingenious in situ self-assembled nanomicelle dissolving microneedle (DMN) patch was designed for intralesional delivery of cell death-inducer (IR780) autophagy inhibitor (chloroquine, CQ) coencapsulated micelles (C/I-Mil) efficient therapy. Upon insertion into skin, the...
Lung cancer with the highest mortality poses a great threat to human health. Ferroptosis therapy has recently been raised as promising strategy for lung treatment by boosting reactive species (ROS) production and lipid peroxidation (LPO) accumulation intracellularly. However, insufficient intracellular ROS level unsatisfactory drug in lesions hamper efficacy of ferroptosis therapy. Here, an inhalable biomineralized liposome LDM co-loaded dihydroartemisinin (DHA) pH-responsive calcium...
With the development of nanotechnology and confronting problems traditional pharmaceutical formulations in treating lung diseases, inhalable nano-formulations have attracted interest. Inhalable for diseases allow precise pulmonary drug delivery, overcoming physiological barriers, improving aerosol deposition rates, increasing bioavailability. They are expected to solve difficulties faced diseases. However, limited success has been recorded industrialization translation nano-formulations....
When nanoparticles were introduced into the biological media, protein corona would be formed, which endowed with new bio-identities. Thus, controlling formation is critical to in vivo therapeutic effect. Controlling particle size most feasible method during design, and influence of media pH varies disease condition quite important. The impact on bovine serum albumin (BSA) solid lipid (SLNs) was studied here. BSA SLNs increasing (120–480 nm) 6.0 7.4 investigated. Multiple techniques employed...
Ferroptosis therapy by catalyzing the Fenton reaction has emerged as a promising tumor elimination strategy for lung adenocarcinoma (ADC). However, unsatisfactory efficiency, strong intracellular antioxidant system, and insufficient drug accumulation limits ferroptosis therapeutic effect. To address these issues, an inhalable nanoreactor was proposed spontaneously adsorbing biomimetic protein corona (PC) composed of matrix metalloproteinase 2 responsive gelatin glutamate (Glu) on surface...
Deep eutectic solvents (DESs) are considered one of the most promising biomass pretreatment reagents, and their research applications in woody fibrous increasing yearly.
In this review, we provide a comprehensive overview and analysis of the current advancements in nanomedicines for targeted pulmonary delivery.
Background Spinal cord injuries are highly disabling and deadly injuries. Currently, few studies focus on non-traumatic spinal injuries, there is little information regarding the risk factors for complete This study aims to describe demographics injury characteristics both traumatic explore Methods A retrospective was performed by reviewing medical records of 3,832 patients with who were first admitted sampled hospitals in Guangdong, China. The described compared between different groups...
Abstract Combination therapy of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (EGFR TKIs) with other chemotherapeutic agents is a feasible strategy to overcome resistance that often occurs after 9–13 months EGFR TKIs administration in nonsmall cell lung cancer (NSCLC). In this study, pulmonary microspheres system codelivers afatinib and paclitaxel (PTX) developed for treatment resistant NSCLC. system, loaded stearic acid‐based solid lipid nanoparticles, then these...
Abstract Black phosphorus (BP) nanosheets emerged as promising 2D nanomaterial that have been applied to eradicate antibiotic‐resistant bacteria. However, their applications are limited by intrinsic ambient instability. Here, the ε ‐poly‐ l ‐lysine ( ‐PL)‐engineered BP constructed via simple electrostatic interaction cater demand for passivating with amplified antibacterial activity. The dual drug‐delivery complex named BP@ε‐PL can closely anchor onto surface of bacteria, leading membrane...
While single-view 3D reconstruction has made significant progress benefiting from deep shape representations in recent years, garment is still not solved well due to open surfaces, diverse topologies and complex geometric details. In this paper, we propose a novel learn-able Anchored Unsigned Distance Function (AnchorUDF) representation for single image. AnchorUDF represents shapes by predicting unsigned distance fields (UDFs) enable surface modeling at arbitrary resolution. To capture...
Abstract Background The aim of this study is to build a prognostic model for cutaneous melanoma (CM) using fatty acid-related genes and evaluate its capacity predicting prognosis, identifying the tumor immune microenvironment (TIME) composition, assessing drug sensitivity. Methods Through analysis transcriptional data from TCGA-SKCM GTEx datasets, we screened differentially expressed acids-related (DEFAGs). Additionally, employed clinical GSE65904 identify associated with prognosis....
Background Multiple evidence suggests that thyroid function is associated with polycystic ovary syndrome (PCOS), but whether causally related to PCOS unclear. To investigate the association reflect causality, a Mendelian randomization (MR) analysis was conducted. Methods Single nucleotide polymorphisms (SNPs) involved in this study were acquired from The ThyroidOmics Consortium and IEU Open Genome-wide (GWAS) database, respectively. In forward MR analysis, we included normal free thyroxine...