A5100320797- Neurological Disease Mechanisms and Treatments
- Eicosanoids and Hypertension Pharmacology
- Cancer, Hypoxia, and Metabolism
- Cardiovascular Health and Disease Prevention
- Hormonal Regulation and Hypertension
- Nitric Oxide and Endothelin Effects
- Cerebrovascular and Carotid Artery Diseases
- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Alcohol Consumption and Health Effects
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiovascular Health and Risk Factors
- Mitochondrial Function and Pathology
- Health, Environment, Cognitive Aging
- Renin-Angiotensin System Studies
- Growth Hormone and Insulin-like Growth Factors
- Advanced Drug Delivery Systems
- Personality Traits and Psychology
- Race, Genetics, and Society
- Intracranial Aneurysms: Treatment and Complications
- Ovarian function and disorders
- Protein Tyrosine Phosphatases
- Clusterin in disease pathology
- Cardiovascular Conditions and Treatments
- Birth, Development, and Health
University of Mississippi Medical Center
2019-2025
Shandong First Medical University
2024
Shandong Provincial Hospital
2024
Beijing University of Chinese Medicine
2023
West China Hospital of Sichuan University
2022
Sichuan University
2022
University of Mississippi
2019-2021
Qingdao University
2020-2021
Affiliated Hospital of Qingdao University
2020-2021
Jackson Memorial Hospital
2020
Epidemiological studies demonstrate that there are sex differences in the incidence, prevalence, and outcomes of cerebrovascular disease (CVD). The present study compared structure composition middle cerebral artery (MCA), neurovascular coupling, function cognition young Sprague-Dawley (SD) rats. Wall thickness inner diameter MCA were smaller females than males. Female exhibited less vascular smooth muscle cells (VSMCs), diminished contractile capability, more collagen media, a thicker...
Background Multiple evidence suggests that thyroid function is associated with polycystic ovary syndrome (PCOS), but whether causally related to PCOS unclear. To investigate the association reflect causality, a Mendelian randomization (MR) analysis was conducted. Methods Single nucleotide polymorphisms (SNPs) involved in this study were acquired from The ThyroidOmics Consortium and IEU Open Genome-wide (GWAS) database, respectively. In forward MR analysis, we included normal free thyroxine...
<title>Abstract</title> Although high-throughput DNA/RNA sequencing technologies have generated massive genetic and genomic data in human disease, these findings not been translated into new patient treatments. To address this problem, we utilized Mendelian randomization (MR) large patient-level functional to evaluate druggable targets using Alzheimer’s disease (AD) as a prototypical example. Specifically, applied the instruments from 9 expression quantitative trait loci (eQTL) 3 protein...
We recently reported that KO of Dual-specificity protein phosphatase 5 (Dusp5) enhances myogenic reactivity and blood flow autoregulation in the cerebral renal circulations association with increased levels pPKC pERK1/2 arteries arterioles. In kidney, hypertension-related damage was significantly attenuated Dusp5 rats. Elevations promote calcium influx VSMC facilitate vasoconstriction. However, whether DUSP5 plays a role altering passive mechanical properties arterioles has never been...
Dual-specificity protein phosphatase 5 (DUSP5) is a member of the tyrosine-threonine family with ability to dephosphorylate and inactivate extracellular signal-related kinase (ERK). The present study investigates whether knockout (KO) <i>Dusp5</i> improves renal hemodynamics protects against hypertension-induced injury. expression DUSP5 was reduced, levels phosphorylated (p) ERK1/2 p-protein C (PKC) <i>α</i> were elevated in KO rats. enhanced myogenic tone afferent arteriole interlobular...
We recently reported that the enhanced susceptibility to chronic kidney disease (CKD) in fawn-hooded hypertensive (FHH) rat is caused, at least part, by a mutation γ-adducin (ADD3) attenuates renal vascular function. The present study explored whether Add3 contributes modulation of podocyte structure and function using FHH FHH. transgenic rats. expression ADD3 on membrane primary podocytes isolated from was reduced compared with found F-actin nets, which are typically localized lamellipodia,...
Diabetes is the primary pathological factor attributed to Alzheimer’s disease and vascular cognitive impairment. Previous studies demonstrated that hyperglycemia promoted oxidative stress in cerebral vasculature. Cerebrovascular pericytes contribute maintaining blood-brain barrier (BBB) integrity regulating blood flow (CBF). However, whether diminishes contractile capability of pericytes, impairs CBF autoregulation increases BBB permeability are unclear. In present study, we examined role...
We have previously identified an inactivating mutation of ADD3 in FHH rats which is associated with impaired myogenic reactivity renal arterioles and podocyte function, contributes to the development CKD. found that SNPs human ADD1 or same region as Add3 are linked reductions brain volumes performance on cognitive tests 4,286 elderly patients (67-90 years old) Atherosclerosis Risk Communities Neurocognitive Study (ARIC-NCS), but mechanisms these pathologies unclear. The present study...
Alzheimer's Disease (AD) is the primary cause of dementia and characterized by extracellular beta-amyloid plaques intracellular hyperphosphorylated tau-containing neurofibrillary tangles in brain. Emerging evidence suggests that cerebrovascular dysfunction associated with AD. Although two-thirds AD patients are female, sex differences transgenic models have been largely ignored. The present study investigated potential mechanisms using a TgF344-AD rat model. APP/PS1 rats serve as preferred...
The purpose of this study was to summary the characteristics ophthalmic artery (OphA) aneurysms and obtain independent risk factors for poor prognosis microsurgical clipping treatment OphA aneurysms.The clinical results all 63 patients with aneurysm were investigated reviewed. patient's case records reviewed including characteristics, image findings, outcomes. Then, analyzed retrospectively.Monocular blindness persisted in 4 (6.35%), 1 patient developed persistent vegetate state (PVS)...
Little systematic research on the antecedents of counterproductive work behaviors(CWBs) has been focusing both individual differences and environmental variables simultaneously. This survey study explored effects big five personality dimensions CWBs. We also testified moderating Perceived Organizational Support (POS) .Using data 447 participants, hierarchical regression analyses revealed that conscientiousness had significant predictive power property CWB production CWB. Among factors,...
ABSTRACT We previously reported that deficiency in 20-HETE or CYP4A impaired the myogenic response and autoregulation of cerebral blood flow (CBF) rats. The present study demonstrated was coexpressed with alpha-smooth muscle actin (α-SMA) vascular smooth cells (VSMCs) most pericytes along parenchymal arteries (PAs) isolated from SD Cell contractile capabilities VSMCs were reduced a synthesis inhibitor, N-Hydroxy-N′-(4-butyl-2-methylphenyl)-formamidine (HET0016) but restored analog...
Diabetes is an important risk factor for dementia. We previously reported that cognitive dysfunction associated with impaired cerebral vascular function in our diabetic rat model. Hyperglycemia contributes to endothelial by increasing the production of reactive oxygen species (ROS). However, role changes mitochondrial dynamics altering autoregulation blood flow and loss diabetes unknown. The present study examined myogenic response middle arteries (MCAs), as well fission primary smooth...
Abstract Background Diabetes mellitus (DM) is a leading risk factor for aging‐related dementia. We previously demonstrated that an SGLT2 inhibitor (SGLT2i) reversed the impaired myogenic response (MR) of middle cerebral artery (MCA) and blood flow (CBF) autoregulation on surface cortex, improved cognition with eight‐arm water maze in 18‐month old diabetic rats. The present study aims to investigate whether normalizing plasma glucose by inhibition also ameliorate MR parenchymal arteriole (PA)...
Objective To investigate the health status of seafarers in Yantai port, and to analyze influential factors chronic diseases, so as provide reliable evidence for development related prevention treatment measures. Methods Medical check-up data 10 200 from our hospital were random selected study, collected classified analyzed. Results The morbidity rate diseases among port was 34.62%. Statistical analyses indicated that hypertension, hyperlipidemia, coronary heart disease, fatty...
Transient receptor potential channel 6 (TRPC6) is a nonselective cation belonging to the TRP ion family and expressed in vascular smooth muscle cells. TRPC6 regulates calcium influx response wall mechanical stretch. A previous study reported that critical for myogenic of middle cerebral artery (MCA). Impaired MCA implicated blood flow dysfunction may promote cognitive deficits. In this study, we investigated whether contributes at pressure range (from 40 180 mmHg) 12-week-old male wild-type...
To illustrate the cerebral protective effect of scalp mechanical stimulation (SMS) on edema in rats with hypoperfusion. First, we screened strength SMS by measuring skin temperature and blood perfusion using laser speckle contrast imaging. Next, observed effects perfusion, edema, pathological changes modified two-vessel carotid artery occlusion (2-VO). Furthermore, apoptosis-related proteins (caspase-3, cleaved-caspase-3) related [antiglial fibrillary acidic protein (GFAP) antiaquaporin-4...
The FHH rat is a genetic model of hypertension that develops proteinuria, glomerulosclerosis, and chronic kidney disease. However, the causes are unknown. We have previously identified an inactivating mutation Add3 in rats association with reduced ADD3 expression impaired myogenic reactivity renal arterioles. vascular impairment dysfunction were restored knock-in wild type (WT) rats. present study examined whether knockout (KO) normal WT impairs response afferent arteriole (Af-art),...
20-HETE is synthesized from arachidonic acid by cytochrome P450 (CYP) enzymes 4A and 4F. Inactivating mutations in the CYP that produce are associated with hypertension stroke man. We previously revealed inactivating variants of CYP4A/F dementia Atherosclerosis Risk Communities Neurocognitive Study (ARIC-NS) population. involved sodium regulation kidney a powerful vasoconstrictor. It was recently discovered CCL5 share same receptor, GPR75. found constricts augments myogenic response (MR)...