A5001025883- Advancements in Transdermal Drug Delivery
- Nanoplatforms for cancer theranostics
- Immunotherapy and Immune Responses
- Advanced Nanomaterials in Catalysis
- Cancer Immunotherapy and Biomarkers
- Gold and Silver Nanoparticles Synthesis and Applications
- Drug Solubulity and Delivery Systems
- Sulfur Compounds in Biology
- Nanoparticle-Based Drug Delivery
- Antimicrobial agents and applications
- Advanced Drug Delivery Systems
- MicroRNA in disease regulation
- Ubiquitin and proteasome pathways
- Protein purification and stability
- Anesthesia and Pain Management
- Cancer-related molecular mechanisms research
- Pediatric health and respiratory diseases
- Spectroscopy Techniques in Biomedical and Chemical Research
- Wound Healing and Treatments
- Autophagy in Disease and Therapy
- Dental Anxiety and Anesthesia Techniques
- RNA Interference and Gene Delivery
- PI3K/AKT/mTOR signaling in cancer
- Biopolymer Synthesis and Applications
- Synthetic Organic Chemistry Methods
Sun Yat-sen University
2009-2024
Xi'an Jiaotong University
2024
Gannan Medical University
2023
Fujian University of Traditional Chinese Medicine
2021
In this study, an ingenious core–shell structure microneedle (CSMN) array was designed to synergistically boost robust immune response by the intralesional codelivery of photosensitizer and indoleamine 2,3-dioxygenase (IDO) blockade. Photosensitizer indocyanine green encapsulated into chitosan nanoparticles (ICG-NPs), followed concentrating on tip shell microneedles. 1-Methyl-tryptophan loaded cross-linked poly(vinyl pyrrolidone) alcohol) gel as core. Through direct deposition ICG-NP-loaded...
High aggressiveness and recurrence of melanoma tumors require multiple systemic drug administrations, causing discomfort severe side effects to the patients. Topical treatment strategies that provide repetitively controllable precise administrations will greatly improve effects. Methods: In this study, a spatiotemporally controlled pulsatile release system, which combined dissolving microneedles (DMNs) thermal-sensitive solid lipid nanoparticles (SLNs), was constructed realize doses...
Infection is the major reason that people die from burns; however, traditional medical dressings such as gauze cannot restrain bacterial growth and enhance healing process. Herein, an organic- inorganic-base hydrogel with antibacterial activities was designed prepared to treat burn wounds. Oxidized dextran (ODex) adipic dihydrazide grafted hyaluronic acid (HA-ADH) were prepared, mixed quaternized chitosan (HACC) silver nanoparticles fabricate Ag@ODex/HA-ADH/HACC hydrogel. The hydrogel,...
The rapid release of poorly water-soluble drugs from amorphous solid dispersion (ASD) is often associated with the generation supersaturated solution, which provides a strong driving force for precipitation and results in reduced absorption. Precipitation inhibitors, such as polymers surfactants, are usually used to stabilize solution by blocking way kinetic or thermodynamic crystal growth. To evaluate combined effect surfactants on maintaining state itraconazole (ITZ), various were...
The excessive colonization of Propionibacterium acnes (P. acnes) is responsible for the genesis acne vulgaris, a common inflammatory disease skin. However, conventional anti-acne therapies are always limited by various side effects, drug resistance, and poor skin permeability. Microneedles (MNs) emerging topical delivery systems capable noninvasively breaking through stratum corneum barrier to efficiently enhance transdermal penetration. Herein, MNs loaded with intelligent pH-sensitive...
Abstract FBXO32, a member of the F-box protein family, is known to play both oncogenic and tumor-suppressive roles in different cancers. However, functions molecular mechanisms regulated by FBXO32 lung adenocarcinoma (LUAD) remain unclear. Here, we report that overexpressed LUAD compared with normal tissues, high expression correlates poor prognosis patients. Firstly, observed series functional experiments alters cell cycle promotes invasion metastasis cells. We further corroborate our...
The therapeutic efficacy of cisplatin has been restricted by drug resistance cancers. Intracellular glutathione (GSH) detoxification under the catalysis S-transferases (GST) plays important roles in development resistance. Herein, a strategy "pincer movement" based on simultaneous GSH depletion and GST inhibition is proposed to enhance cisplatin-based chemotherapy. Specifically, redox-responsive nanomedicine disulfide-bridged degradable organosilica hybrid nanoparticles developed loaded with...
Integrating dissolving microneedles (DMNs) and nanocarriers (NC) holds great potential in transdermal drug delivery because it can simultaneously overcome the stratum corneum barrier achieve efficient controlled delivery. However, different skin sites with thicknesses compositions affect diffusion of NC-loaded DMNs. There are few reports on biological fate (especially diffusion) DMNs, inaccurate bioimaging information intact NC limits accurate understanding vivo The aggregation-caused...
With the development of modern medical technology, common diseases usually can be treated by traditional medicines and their formulation, while with multiple etiologies still remain a great challenge in clinic. Nanoformulation was widely explored to address this problem. However, due limited drug loading space nanocarriers, co-delivery strategy fails achieve sufficient drugs simultaneously. In research, we potential poly(ethylene glycol) (PEG) crosslinked alternating copolymers MPLL-alt-PEG...
Colon cancer ranks second in overall cancer-related deaths and poses a serious risk to human life health. In recent years, exosomes are believed play an important significant role cancer, especially tumor-derived (TDEs). Previous studies have highlighted the pivotal of tumor development, owing their ability mediate communication between cells macrophages, induce macrophage M2 polarization, facilitate progression tumorigenesis. this study, we revealed that colon cancer-derived promoted...
Phototherapy has emerged to eradicate recalcitrant bacteria without causing drug resistance, but it is often accompanied by considerable limitations owing a high tolerance of heat and oxidative damage, leading low efficiency monotherapy unwanted side effects. Assuming that employing antimicrobial peptides (AMPs) disrupt bacterial membranes could reduce tolerance, multifunctional "on-demand" nanosystem based on zeolitic imidazolate framework-8 (ZIF-8) with metal ions for intrinsic...
Fenofibrate (FNB) is an effective drug for the treatment of hypertriglyceridemia, hypercholesterolemia as well mixed hyperlipidemia. However, due to its poor aqueous solubility, FNB has problem oral absorption followed by low bioavailability.The aim this research was construct amorphous solid dispersion employing PVP VA64 carrier hot-melt extrusion method, in order improve bioavailability. Additionally, cell transport experiment conducted further investigate mechanism promoted osmotic...
Abstract Triple‐negative breast cancer (TNBC) remains one of the most fatal diseases in human populations, characterized by a high incidence and mortality rate. Although conjunction chemotherapeutic agents, like nanoparticle albumin‐bound paclitaxel (nab‐PTX), immune checkpoint inhibitors, exemplified anti‐PD‐1 antibody (aPD‐1), has surfaced as promising modality for TNBC treatment, optimization their synergistic therapeutic impact while concurrently curtailing associated adverse reactions...
Dissolving microneedles (DMNs) hold great popularity because of their precise drug delivery and administration portability. DMNs with different lengths could reach depths punctures that consequently resulted in diffusive effects. Therefore, to clarify the effect length needles on vivo fate is significance. In this study, solid lipid nanoparticles (SLNs) were chosen as model NC loaded DMNs. To unambiguously determine biological DMNs, P4 probe aggregation caused quenching property was...