Abstract FBXO32, a member of the F-box protein family, is known to play both oncogenic and tumor-suppressive roles in different cancers. However, functions molecular mechanisms regulated by FBXO32 lung adenocarcinoma (LUAD) remain unclear. Here, we report that overexpressed LUAD compared with normal tissues, high expression correlates poor prognosis patients. Firstly, observed series functional experiments alters cell cycle promotes invasion metastasis cells. We further corroborate our...

Abstract TNF receptor‐associated factor 3 interacting protein (TRAF3IP3/T3JAM) exhibits dual roles in cancer progression. While upregulated most malignancies and critical for immune regulation. However, the specific effects molecular mechanisms of TRAF3IP3 on progression lung adenocarcinoma (LUAD) remains poorly understood. This study reveals is several tumor tissues but exclusively decreased LUAD Lung squamous cell carcinoma (LUSC) tissues, consequential a favorable overall survival (OS)...

To evaluate the safety and efficacy of transarterial arterial chemoembolization (TACE) with gelatin sponge particles (GSPs-TACE) Huaier granule to treat primary hepatic carcinoma (PHC). A series 62 patients PHC were included between June 2009 December 2011, randomly assigned a control (n = 31) or an experimental group 31). The received TACE 350 560 μm GSPs plus lobaplatin chemotherapy. Patients in granule. Treatment mid-to-long-term evaluated. Follow-up ranged from 12 24 months mean 28.7...

Abstract Background Breast cancer is one of the most common cancers in world, and identification biomarkers for early detection breast a relevant target. The present study aims to determine serum peptidome patterns screening cancer. Methods work focused on proteomic analysis 36 healthy volunteers 37 patients using ClinProt Kit combined with mass spectrometry (MS). This approach allows determination that are able differentiate studied populations. An independent group sera (36 patients) was...

The study aimed to retrospectively evaluate the success rate, utility, practicality and results of pre-operative CT (computed tomography)–guided semi-rigid single hook-wire placement pathology small pulmonary nodules (SPN). Seventy-four patients with 81 underwent CT-guided hook wire localization consecutively between 2016 2017 were reviewed. VATS (video-assisted thoracoscopic surgery) resection lung tissue containing each nodule performed in direction wire. rate utility localization, related...

Abstract Background To observe the medium- and long-term clinical efficacy safety of radioactive 125 I seed implantation for refractory malignant tumours based on CT-guided 3D template-assisted technique. Methods Twenty-five patients with who underwent technique were selected. The post-operative adverse reactions recorded. number puncture needles particles used in operation, dosimetric parameters, physical strength scores, tumour response statistically analysed. overall survival time rate...

Background: As a new style of cell death, necroptosis plays crucial role in tumor immune microenvironment. LncRNAs have been identified to act as competitive RNAs influence genes involved necroptosis. Therefore, we aim create signature based on necroptosis-related lncRNAs predict the prognosis and landscape lung adenocarcinoma (LUAD) patients this study. Methods: TCGA database was used acquire RNA sequencing (RNA-Seq) data clinical information for 59 normal samples 535 samples. The Pearson...

This study aimed to prospectively observe the efficacy and safety of CalliSpheres drug-eluting beads bronchial arterial chemoembolization (DEB-BACE) for refractory non-small-cell lung cancer (NSCLC).The interventional therapy plan was as follows: 300-500 μm drug-loaded microspheres were loaded with epirubicin, then slow embolization tumor supplying artery performed after microcatheter superselection. Chest enhanced computed tomography related hematological examination reviewed 2 months...

Background . Colorectal cancer (CRC) is one of the most common cancers in world, identification biomarkers for early detection CRC represents a relevant target. The present study aims to determine serum peptidome patterns diagnosis. Methods work focused on proteomic analysis 32 health volunteers and 38 by ClinProt Kit combined with mass spectrometry. This approach allowed construction peptide able differentiate studied populations. An independent group (including 33 volunteers, 34 CRC, 16...

Tumor cells tend to utilize glycolysis rather than aerobic respiration even under conditions. OVOL2, an inhibitory C2H2 zinc finger transcription factor, is a potential tumor suppressor in cancers. However, the association between OVOL2 and energy metabolism unknown.Western blotting was used determine expression of different non-small cell lung cancer (NSCLC) lines mouse models. The metabolic parameters NSCLC following overexpression or knockdown were examined. To define mechanism by which...

Abstract Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers in world. Early diagnosis critical for guiding therapeutic management ESCC. The present study aims to determine serum peptidome patterns diagnosing To identify novel ESCC, sera from 31 healthy volunteers and 32 ESCC patients were subjected a comparative proteomic analysis using ClinProt™ Kit combined with mass spectrometry (MS). This approach enables determination that can differentiate between volunteers....

Increasing evidence showed that the dysregulation of DNA methylation regulators is a decisive feature almost all cancer types and affects tumor progressions. However, few studies focused on underlying influences regulators-related genes (DMRegs) in immune cell-infiltration characteristics, microenvironment (TME) immunotherapy HCC patients. In our study, alterations modification patterns (DMRPs) were clustered from hepatocellular carcinoma (HCC) samples based expression as well genetic...

Esophageal cancer (EC) is one of the most common malignant tumors, and incidence esophageal squamous cell carcinoma (ESCC) highest in China. Early diagnosis effective monitoring are keys to comprehensive treatment discovering tumor metastases recurrence time. The aim this study was confirm serum peptidome pattern utility for ESCC, assessment operation success, postoperative chemotherapy results, metastasis recurrence. Serum samples were collected from 61 patients treated with surgery 20...

Lung adenocarcinoma (LUAD) is a highly aggressive cancer in advanced stages and has the highest cancer-related death across world. Anoikis emerged as specific form of apoptotic cell that may play vital role formation development tumors.Based on The Cancer Genome Atlas dataset, we developed novel anoikis-related genes (ARGs) signature LUAD evaluated differences between low high-risk groups clinical characteristics, expression patterns, immune infiltration, drug sensitivity, etc. According to...

Abstract Lung cancer is the leading cause of cancer-related death. Lysosomes are key degradative compartments that maintain protein homeostasis. In current study, we aimed to construct a lysosomes-related genes signature predict overall survival (OS) patients with Adenocarcinoma (LUAD). Differentially expressed (DELYs) were analyzed using The Cancer Genome Atlas (TCGA-LUAD cohort) database. prognostic risk was identified by Least Absolute Shrinkage and Selection Operator (LASSO)-penalized...

Objective To explore the clinical efficacy and prognostic factors of use Gelfoam for drug-eluting bead (DEB) transarterial chemoembolization (GMD-TACE) in patients with unresectable large hepatocellular carcinoma (HCC) portal vein tumor thrombus (PVTT).

To retrospectively analyze the safety and efficacy of 350–560 μm gelatin sponge particles combined with single-chemotherapy drug transcatheter arterial chemoembolization (Gs-TACE) for treatment elderly hepatocellular carcinoma without surgical resection. Thirty patients resection, who received Gs-TACE in our hospital, were selected. Slowly injected (350–560 μm)+ 10 mg lobaplatin injection into regional embolization tumor target vessel. The Response Evaluation Criteria Solid Tumors could be...

A pathologically confirmed negative margin is required when performing sublobar resection in patients with early stage peripheral lung adenocarcinoma. However, the optimal distance to ensure complete tumor while preserving healthy tissue remains unknown. We aimed establish a reliable range for margins.A total of 52 intraoperative para-cancer specimens from adenocarcinoma pathological tumors ≤2 cm size were examined. Depending on edge (D), tissues divided into following five groups: D < 0.5...

Abstract Objective To retrospectively analyze the safety and long-term clinical efficacy of gelatin sponge microparticles combined with chemotherapy drug pirarubicin for hepatic transcatheter arterial chemoembolization (GSMs-TACE) in order to treat breast cancer liver metastasis (BCLM). Methods Twenty-seven BCLM patients who underwent GSMs-TACE from July 2010 2016 were enrolled. Tumor target blood vessels slowly regionally embolized absorbable particles injections. Plain computed tomography...

The purpose of this study was to observe the safety and efficacy CalliSpheres microspheres drug-eluting beads (DEB) transhepatic arterial chemoembolization (CSM-TACE) for liver metastasis gastric cancer (GCLM) combined with trans-arterial infusion therapy (TAIT) as primary focus cancer.Unresectable advanced GCLM patients were collected retrospective analysis. Patients who progressed after chemotherapy or could not receive systematic selected. CSM-TACE used treatment oxaliplatin TAIT cancer....

To assess the clinical efficacy and safety of gelatin sponge microparticles-transcatheter arterial chemoembolization (GSMs-TACE) plus synchronous antigen-presenting dendritic cell (DC) sequential reinfusion for advanced large liver cancer (LC).Patients with LC were assigned to experimental (combined DC therapy) or control group. All patients received standardized GSMs-TACE. In group, 60 mL peripheral blood was collected in vitro culture DCs (10-14 days). Then, intravenous conducted 3 times...

Background: The aim of this study was to compare the effects currently available preoperative localization methods, including semi-rigid single hook-wire, double-thorn and microcoil, in localizing pulmonary nodules, thus select best technology assist video-assisted thoracoscopic surgery (VATS) for small ground glass opacities (GGO). Methods: Preoperative CT-guided techniques hook-wire microcoil were used re-aerated fresh swine lung location experiments. advantages drawbacks three positioning...