A5066926559- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastric Cancer Management and Outcomes
- Cancer Mechanisms and Therapy
- Liver Disease and Transplantation
- Pharmacogenetics and Drug Metabolism
- Liver physiology and pathology
- Lung Cancer Treatments and Mutations
- Drug Transport and Resistance Mechanisms
- Cancer Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Head and Neck Cancer Studies
- MRI in cancer diagnosis
- Medical Imaging and Pathology Studies
- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Renal cell carcinoma treatment
- Cancer, Lipids, and Metabolism
- Enhanced Recovery After Surgery
- Neurological Disease Mechanisms and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Advanced Nanomaterials in Catalysis
- Esophageal and GI Pathology
- RNA modifications and cancer
Chongqing University
2025
National Research Institute of Brewing
2025
Zhengzhou University
2015-2024
Zhongnan Hospital of Wuhan University
2010-2024
Wuhan University
2010-2024
Henan Provincial People's Hospital
2022
Affiliated Zhongshan Hospital of Dalian University
2016-2022
First Affiliated Hospital of Xi'an Jiaotong University
2022
Dalian University
2021-2022
Zhengzhou People's Hospital
2022
The lack of information concerning individual variation in content and activity human liver microsomal protein is one the most important obstacles for designing personalized medicines. We demonstrated that mean value per gram (MPPGL) was 39.46 mg/g 128 livers up to 19-fold variations existed. Meanwhile, metabolic activities 10 cytochrome P450 (CYPs) were detected microsomes tissues, respectively, which showed huge (200-fold). Compared with microsomes, tissues much suitable express CYP...
The present study aimed to evaluate the short-term efficacy and safety of drug-eluting beads transarterial chemoembolization (DEB-TACE) with CalliSpheres Beads loaded doxorubicin (DOX) in treatment Chinese patients hepatocellular carcinoma (HCC) compared conventional TACE (cTACE). A total 54 HCC treated by from June 2016 February 2017 were retrospectively analyzed. These included 24 cases DEB-TACE group 30 cTACE group. clinical efficacy, tumor recurrence rate, complications between two...
Breast cancer is the leading cause of cancer-associated mortality in females. It has an incidence 1.3 million per year, which increases by 2% annually. In China, breast accounts for 12.2% all cases. The aim present study was to investigate inhibitory effect naringenin on triple-negative cells. Lactate dehydrogenase and MTT assay used MDA-MB-231 cell viability. Naringenin reduced viability cells arresting cycle at G2 phase. treatment not only influenced phase arrest, but also induced...
Human cytochrome b5 (Cyt b5) plays important roles in P450 (CYP)-mediated drug metabolism. However, the expression level of Cyt normal human liver remains largely unknown. The effect on overall CYP activity microsomes (HLM) has rarely been reported and relationship between polymorphic not systematically investigated. In this study, we found that median value protein was 270.01 pmol/mg from 123 HLM samples, 12- 19-fold individual variation observed mRNA levels, respectively. Gender smoking...
This study aimed to compare the efficacy and safety between transarterial chemoembolization (TACE) with CalliSpheres® microspheres (CSM-TACE) conventional TACE (cTACE) in patients hepatocellular carcinoma (HCC). Three hundred thirty-five HCC receiving CSM-TACE or cTACE were consecutively enrolled this multi-center, retrospective cohort study, then divided into group accordingly. Complete response (CR), objective (ORR) disease control (DCR) was assessed according mRECIST criteria at 1 month...
// Jie Gao 1 , Gao-Ju Wang Zhao Na Jing Li Yun-Fei Zhang 1,2 Jun Zhou 1,3 Hong-Xin Qiang Wen Han Jin and Hai-Ling Qiao Institute of Clinical Pharmacology, Zhengzhou University, Zhengzhou, Henan, China 2 Affiliated Cancer Hospital 3 Provincial People's Correspondence to: Qiao, email: Keywords : cytochrome P450 2E1; hepatic fibrosis; causal role; prevention; diethylnitrosamine; Gerotarget Received July 06, 2017 Accepted November 14, Published December 05, Abstract Hepatofibrosis, which leads...
This study aimed to compare efficacy and safety of HepaSpheres CalliSpheres in unresectable large hepatocellular carcinoma (HCC) patients. One hundred twenty-seven HCC patients receiving drug-eluting bead transarterial chemoembolization (DEB-TACE) treatment with or microspheres were analyzed. Treatment response, Karnofsky performance status (KPS) score, adverse events, main liver function indexes, time progression (TTP), overall survival (OS) Objective response rate (82.7% vs. 63.8%, p=.030)...
Hepatofibrosis is an important susceptibility factor for hepatocarcinogenesis. However, only a handful of cases hepatofibrosis will develop into hepatocellular carcinoma (HCC). As cytochrome P450 2E1 (CYP2E1) involved in the metabolism and activation many known environmental toxicants procarcinogens, this enzyme may play role development hepatocarcinogenesis subsequent to hepatofibrosis. Herein, we evaluated whether higher CYP2E1 activity risk from fibrotic tissues 72 HCC patients normal...
Abstract Background Although an association between the cytochrome P4502D6 (CYP2D6) *10 (100C>T) polymorphism and hepatocellular carcinoma (HCC) is known, mechanism remains unclear. Here we aimed to explore mechanisms of CYP2D6*10 conferring HCC, screen markers for HCC. Methods Label-free global proteome profiling with 34 normal livers peritumor tissue from 61 HCC patients was performed, angiopoietin-like protein-6 (ANGPTL6) evaluated in 2 liver samples validation cohorts blood specimens...
Background/ Aims: Little is known about the effect of P450 oxidoreductase (POR) gene polymorphisms on activities CYPs with multiple genotypes.We genotyped 102 human livers for 18 POR single nucleotide (SNPs) allelic frequencies greater than 1% as well 27 SNPs in 10 CYPs. CYP enzyme microsomes prepared from these were determined by measuring probe substrate metabolism high performance liquid chromatograph.We found that effects genotype-dependent. The mutations significantly associated...
The potential advantages of Jiedu granule (a compound Chinese herbal medicine) combined therapeutic strategies compared with non-Jiedu for hepatocellular carcinoma (HCC) portal vein tumor thrombosis (PVTT) remain unclear. Thus, the purpose study was to investigate safety and efficacy HCC PVTT.We retrospectively reviewed clinical data 190 patients (94 96 Jiedu) PVTT from March 2012 October 2016. Patients were followed up by outpatient examination telephone till November 2018.It statistically...
The purpose of this investigation is to present a preliminary clinical experience in transarterial chemoembolization (TACE) with gelatin sponge microparticles (GSMs) for barcelona clinic liver cancer (BCLC) Stage C and large hepatocellular carcinoma (HCC) patients China.Between August 2009 2012, 20 BCLC HCC tumor size ≥5 cm undergoing GSMs-TACE were retrospectively analyzed. Tumor response was evaluated using modified evaluation criteria solid tumors (mRECIST) enhanced magnetic...
// Xiao-Jie Lu 1,* , Jing Dong 2,* Li-Juan Ji 3,* Li-Xin Xiao 4 Chang-Quan Ling 5 and Jun Zhou 6 1 Department of Gastroenterology, Shanghai East Hospital, Tongji University School Medicine, Shanghai, China 2 Outpatient Department, Zhejiang Provincial People’s Hangzhou, Province, 3 Rehabilitation, The Affiliated Huai’an Hospital Xuzhou Medical College Second Huai’an, Gamma Knife, 411st Chinese Liberation Army, Changhai Traditional Military University, Oncology Hematology, *...
How genotypic variation results in phenotypic differences is still a challenge for biology. In the field of drug metabolism, means by which specific cytochrome P4502D6 (CYP2D6) genotypes yield different phenotypes at various levels (molecular, cellular, and organismal) an important question, as CYP2D6 activity can contribute to adverse reactions. Herein, genotype was determined along with absolute content microsomal protein per gram liver human microsomes, molecular, cellular (microsomal,...
Spontaneous rupture of hepatocellular carcinoma hemorrhage is life-threatening. The aim the present study was to retrospectively analyze effect gelatin sponge microparticles (GSMs) various diameters on treatment spontaneous hemorrhage. GSMs serve as embolization agents by transcatheter arterial chemoembolization (TACE), and current analyzed their safety efficacy. Data from a total 13 cases hemorrhage, who were treated with GSM-TACE at Affiliated Zhongshan Hospital Dalian University (Dalian,...
Despite significant advancements in cancer immunotherapy, many patients continue to respond poorly. Novel therapeutic strategies and drugs are urgently needed. Here, we found that CYP2E1 is upregulated M2 macrophages. The inhibitor, Q11, could inhibit macrophage polarization, while overexpression promote it. Increased levels of macrophages the tumor microenvironment HCC correlate with poor prognosis. Q11 cells by targeting rather than directly attacking cells. Both Cyp2e1 knockout...
Liver injury has a critical effect on the severity and outcome of sepsis. The impact stored red blood cells (RBCs) pathogenesis sepsis-associated hepatic is not well understood. Therefore, to investigate effects stored-RBC transfusion sepsis-induced liver damage as associated mechanism, we constructed sepsis mouse model enabling noninvasive imaging bacterial infection caused by Pseudomonas aeruginosa, common gram-negative respiratory pathogen. We showed that transfusions with RBCs enhanced...
Abstract To prospectively compare the reproducibility of normal pancreas-normalized apparent diffusion coefficient (ADC) measurements for pancreas and mean normalized ADCs at different anatomic locations. In total, 22 healthy volunteers underwent pancreatic 3.0-T magnetic resonance (MR) imaging, including axial diffusion-weighted (DW) imaging with 3 b values used (0, 400, 800 s/mm 2 ) respiratory-triggered (RT) technique. The from regions interest (ROIs) in 5 locations (head [H], body [B],...