A5026637417- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Autophagy in Disease and Therapy
- Cannabis and Cannabinoid Research
- Epigenetics and DNA Methylation
- RNA and protein synthesis mechanisms
- Cancer, Hypoxia, and Metabolism
- Genomics, phytochemicals, and oxidative stress
- Immune cells in cancer
- Inflammatory mediators and NSAID effects
- Endoplasmic Reticulum Stress and Disease
- Heme Oxygenase-1 and Carbon Monoxide
- Tryptophan and brain disorders
- Urticaria and Related Conditions
- Cancer Mechanisms and Therapy
- Liver Disease Diagnosis and Treatment
- Lung Cancer Research Studies
- Pharmacogenetics and Drug Metabolism
- Forensic Toxicology and Drug Analysis
- Glycosylation and Glycoproteins Research
- Renal Diseases and Glomerulopathies
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Glutathione Transferases and Polymorphisms
- Lipid metabolism and disorders
Nantong University
2024-2025
Zhengzhou University
2021-2024
Nanyang Institute of Technology
2024
China Medical University
2016-2018
Frederick National Laboratory for Cancer Research
2008-2009
National Cancer Institute
2009
Abstract The tumor microenvironment (TME) was usually studied in tissue and relation to only progression, with little involved occurrence, recurrence metastasis of tumor. Thus, a new concept “peritumor (PME)” proposed the proteomic characterization peritumor liver tissues human hepatocellular carcinoma (HCC). PME for occurrence (PME-O) progression (PME-P) were almost totally different at proteome composition function. Proteins rarely overlapped crossed. Immunity played central role PME-O,...
Recent advancements in contemporary therapeutic approaches have increased the survival rates of lung cancer patients; however, long-term benefits remain constrained, underscoring pressing need for novel biomarkers. Surfactant-associated 3 (SFTA3), a long non-coding RNA predominantly expressed normal epithelial cells, plays crucial role development. Nevertheless, its function adenocarcinoma (LUAD) remains inadequately understood. Single-cell sequencing data were utilized to identify...
Glioblastoma (GBM) is a devastating inflammation-related cancer for which novel therapeutic targets are urgently required. Previous studies of the authors indicate Cytochrome P450 2E1 (CYP2E1) as inflammatory target and develop specific inhibitor Q11. Here it demonstrated that CYP2E1 overexpression closely related to higher malignancy in GBM patients. activity positively correlated with tumor weight rats. Significantly expression accompanied by increased inflammation detected mouse model....
Methamphetamine (MA) leads to cardiac and pulmonary toxicity expressed as increases in inflammatory responses oxidative stress. However, some interactions may exist between stress endoplasmic reticulum (ERS). The current study is designed investigate if both ERS are involved MA-induced chronic antioxidant tertiary butylhydroquinone (TBHQ) alleviated ERS-apoptosis by PERK-Nrf2 crosstalk. In this study, the rats were randomly divided into control group, MA-treated group (MA), MA plus...
Methamphetamine (MA) abuse is a major public health and safety concern throughout the world growing burden on healthcare costs. The purpose of present study was to investigate protective effect fluoxetine against MA‑induced chronic pulmonary inflammation evaluate potential role nuclear factor erythroid 2-related 2 (Nrf2)-mediated antioxidative stress. Wistar rats were divided into control, MA two fluoxetine‑treated groups. Rats in groups treated daily with intraperitoneal injection 10 mg/kg...
Background Ribosomal RNA (rRNA) is a central regulator of cell growth and may control cancer development. A cis noncoding rRNA (nc-rRNA) upstream from the 45S transcription start site has recently been implicated in mouse fibroblasts. We investigated whether similar nc-rRNA might be expressed human epithelial cells, related to any genomic characteristics. Methodology/Principal Findings Using quantitative measurement, we demonstrated that transcribed lung starting approximately −1000...
Abstract Objectives Methamphetamine ( MA ) abuse evokes pulmonary toxicity. The aim of our study is to investigate if autophagy induced by and autophagy‐initiated apoptosis in alveolar epithelial cells involved ‐induced chronic Materials Methods rats Control group were tested Doppler HE staining. treated with , following western blot, RT ‐ PCR immunofluorescence assay. Results Chronic exposure resulted lower growth ratio weight higher heart rate peak blood flow velocity the main artery rats....
Abstract Background Although an association between the cytochrome P4502D6 (CYP2D6) *10 (100C>T) polymorphism and hepatocellular carcinoma (HCC) is known, mechanism remains unclear. Here we aimed to explore mechanisms of CYP2D6*10 conferring HCC, screen markers for HCC. Methods Label-free global proteome profiling with 34 normal livers peritumor tissue from 61 HCC patients was performed, angiopoietin-like protein-6 (ANGPTL6) evaluated in 2 liver samples validation cohorts blood specimens...
Despite significant advancements in cancer immunotherapy, many patients continue to respond poorly. Novel therapeutic strategies and drugs are urgently needed. Here, we found that CYP2E1 is upregulated M2 macrophages. The inhibitor, Q11, could inhibit macrophage polarization, while overexpression promote it. Increased levels of macrophages the tumor microenvironment HCC correlate with poor prognosis. Q11 cells by targeting rather than directly attacking cells. Both Cyp2e1 knockout...
The imbalance between oxidative stress and antioxidant defense is important in the pathogenesis of lung diseases. Nuclear factor erythroid‑2‑related 2 (Nrf2) a key transcriptional that regulates response. purpose present study was to investigate whether Nrf2‑mediated antioxidative involved methamphetamine (MA)‑induced injury rats. Following establishment chronic MA toxicity rats, Doppler ultrasonic detection used measure changes physiological indexes, followed by hematoxylin eosin staining,...
The effect of the cytochrome P450 oxidoreductase (POR) rs10954732 (G > A) polymorphism on hepatocellular carcinoma (HCC) susceptibility is unknown. Here we found that A allele carriers showed a 69% decrease in to HCC with overall survival (OS) prolonged 199%, accompanied by lower activity for 2E1. total 222 differentially expressed proteins were mainly enriched neutrophil and T cell activation involved immune inflammatory responses, constituting altered tumor microenvironment related...
Background: ISCA1 (Iron–Sulfur Cluster Assembly 1) is involved in the assembly of iron–sulfur (Fe–S) clusters, which are vital for electron transport and enzyme activity. Some studies suggest potential involvement tumor progression through interactions with ferroptosis-related genes (FRGs) immune microenvironment (TME). However, there has been no systematic analysis its role FRGs TME or predictive value prognosis immunotherapy response across different cancer types. Methods: In this study,...