A5100720761- Toxoplasma gondii Research Studies
- Inflammasome and immune disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Nanoparticles: synthesis and applications
- Advanced Nanomaterials in Catalysis
- Reproductive tract infections research
- Amoebic Infections and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Pharmacological Effects of Natural Compounds
- Endoplasmic Reticulum Stress and Disease
- Immune cells in cancer
- Inflammatory mediators and NSAID effects
- Cytokine Signaling Pathways and Interactions
- Parasitic Infections and Diagnostics
- interferon and immune responses
- Nanoplatforms for cancer theranostics
- Viral-associated cancers and disorders
- Reproductive System and Pregnancy
- Viral Infections and Vectors
- Pediatric health and respiratory diseases
- GDF15 and Related Biomarkers
- Lymphoma Diagnosis and Treatment
- NF-κB Signaling Pathways
- Macrophage Migration Inhibitory Factor
- Paraquat toxicity studies and treatments
Chungnam National University
2019-2024
Guangdong Medical College
2021-2023
Zhengzhou University
2023
Affiliated Hospital of Hebei University
2021
University of Hong Kong
2015-2018
Chinese University of Hong Kong
2015
State Key Laboratory of Oncology in South China
2013
Abstract Transplantation of bone marrow mesenchymal stem cells (BM-MSCs) can protect cardiomyocytes against anthracycline-induced cardiomyopathy (AIC) through paracrine effects. Nonetheless the effects human induced pluripotent cell-derived MSCs (iPSC-MSCs) on AIC are poorly understood. In vitro studies reveal that doxorubicin (Dox)-induced reactive oxidative stress (ROS) generation and cell apoptosis in neonatal rat (NRCMs) significantly reduced when treated with conditioned medium...
This study evaluated the clinical efficacy of autologous cytokine-induced killer (CIK) cell transfusion in combination with transcatheter arterial chemoembolization (TACE) and radiofrequency ablation (RFA), compared to sequential therapy TACE RFA, for treatment hepatocellular carcinoma (HCC). We retrospectively studied 2 groups HCC patients: 85 patients TACE+RFA+CIK group were treated adoptive CIK minimally invasive therapy, 89 TACE+RFA alone. The overall response rate was 76.5% 79.8% group....
Glioblastoma (GBM) is a devastating inflammation-related cancer for which novel therapeutic targets are urgently required. Previous studies of the authors indicate Cytochrome P450 2E1 (CYP2E1) as inflammatory target and develop specific inhibitor Q11. Here it demonstrated that CYP2E1 overexpression closely related to higher malignancy in GBM patients. activity positively correlated with tumor weight rats. Significantly expression accompanied by increased inflammation detected mouse model....
External and internal stimuli easily affect the retina. Studies have shown that cells infected with Toxoplasma gondii are resistant to multiple inducers of apoptosis. Nanoparticles (NPs) been widely used in biomedical fields; however, little is known about cytotoxicity caused by NPs retina modulators inhibit nanotoxicity.ARPE-19 from human retinal pigment epithelium were treated silver nanoparticles (AgNPs) alone or combination T. gondii. Then, cellular toxicity, apoptosis, cell cycle...
Trichomonas vaginalis causes lesions on the cervicovaginal mucosa in women; however, its pathogenesis remains unclear. We have investigated involvement of endoplasmic reticulum (ER) induction apoptosis by T. and molecular mechanisms human cervical cancer SiHa cells.Apoptosis, reactive oxygen species (ROS) production, mitochondrial membrane potential (MMP), ER stress response Bcl-2 family protein expression were evaluated using immunocytochemistry, flow cytometry,...
Toxoplasma gondii is a parasite that primarily infects through the oral route. Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) play crucial roles in immune responses generated during parasitic infection and also drive inflammatory response against invading parasites. However, little known about regulation of NLRs inflammasome activation T. gondii-infected human small intestinal epithelial (FHs 74 Int) cells. FHs Int cells infected with were subsequently evaluated for...
Intervertebral disc degeneration (IVDD) is a common cause of low back pain. This study aimed at investigating the role microRNAs (miRNAs) in regulating human nucleus pulposus (NP) cell injury induced by tumor necrosis factor- (TNF-) α IVDD. In this study, we NP cells with 20 ng/mL TNF-α vitro, which promoted obvious apoptosis and activation nuclear transcription factor (NF)-κB. contrast, using specific NF-κB inhibitor BAY 11-7082 to treat greatly impaired increased sensitivity TNF-α-induced...
The retina is the primary site of Toxoplasma gondii infection in eye, and choroidal neovascularization ocular toxoplasmosis one most important causes visual impairment. Vascular endothelial growth factor (VEGF) key regulators blood vessel development, however, little known about mechanisms T. gondii-induced VEGF production toxoplasmosis. Here, we investigate effect on regulation human retinal pigment epithelium ARPE-19 cells attempted to unveil underlying mechanism this event by focusing...
Background: Breast cancer mortality has been stable or decreasing in the world, its incidence and recurrence rates have sharply risen worldwide recent years. Objective: To investigate clinicopathological significance potential function of GRP78 development progression breast cancer. explore effects neoisoliquiritigenin (NISL) underlying mechanism. Method: was detected by immunohistochemistry (IHC) using tissue microarrays (TMAs), association between levels factors prognosis analyzed. The...
Aim: To investigate the anticancer mechanisms of silver nanoparticles (AgNPs) in colorectal cancer. Methods: Anticancer effects AgNPs were determined cancer HCT116 cells and xenograft mice using cellular molecular methods. Results: induced mitochondrial reactive oxygen species production, dysfunction endoplasmic reticulum (ER) stress responses through NOX4 led to cell apoptosis. Pretreatment with DPI or 4-PBA significantly inhibited apoptosis, ER response, expression AgNP-treated cells. also...
Based on the reactive oxygen species (ROS) regulatory properties of diphenyleneiodonium (DPI), we investigated effects DPI host-infected T. gondii proliferation and determined specific concentration that inhibit intracellular parasite growth but without severe toxic effect human retinal pigment epithelial (ARPE-19) cells. As a result, it is observed host superoxide, mitochondria superoxide H2O2 levels can be increased by DPI, significantly, followed suppression infection proliferation. The...
Targeting altered expression and/or activity of GABA (γ-aminobutyric acid) transporters (GATs) provide therapeutic benefit for age-related impairments, including cognitive dysfunction. However, the mechanisms underlying transcriptional regulation GATs are unknown. In present study, we demonstrated that stimulator interferon genes (STING) upregulates GAT1 and GAT3 in brain, which resulted Genetic pharmacological intervention STING suppressed both GAT3, increased ambient concentration,...
Abstract Background: Toxoplasma gondii is a parasite that majorly infects through the oral route. Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) play crucial roles in immune responses generated during parasitic infection and also drive inflammatory response against invading parasites. However, little known about regulation of NLRs inflammasome activation T. -infected human small intestinal epithelial (FHs 74 Int) cells. Methods: FHs Int cells infected with were...
Abstract Background: Human trichomoniasis is one of the most common sexually transmitted infections; however, its pathogenesis remains unclear. Here, we investigated role endoplasmic reticulum (ER) in apoptosis induction by T. vaginalis human cervical epithelial SiHa cells Methods: We evaluated cytotoxicity, apoptosis, reactive oxygen species (ROS) production, mitochondrial membrane potential (MMP), ER stress response, and Bcl-2 family protein expressions using LDH assay,...