A5083050578- Food Quality and Safety Studies
- Phytochemicals and Antioxidant Activities
- Toxoplasma gondii Research Studies
- Advanced Glycation End Products research
- 3D Printing in Biomedical Research
- Pharmacological Effects of Natural Compounds
- Protein Hydrolysis and Bioactive Peptides
- Adipose Tissue and Metabolism
- Microfluidic and Capillary Electrophoresis Applications
- Parasite Biology and Host Interactions
- Cytomegalovirus and herpesvirus research
- Helminth infection and control
- Bioactive natural compounds
- Innovative Microfluidic and Catalytic Techniques Innovation
- Ginseng Biological Effects and Applications
- Natural product bioactivities and synthesis
- Biochemical effects in animals
- Adipokines, Inflammation, and Metabolic Diseases
- Alcohol Consumption and Health Effects
- Polysaccharides and Plant Cell Walls
- Heme Oxygenase-1 and Carbon Monoxide
- Fatty Acid Research and Health
- Herpesvirus Infections and Treatments
- Essential Oils and Antimicrobial Activity
- Tea Polyphenols and Effects
Korea Food Research Institute
2014-2024
Chungnam National University
2012-2023
Jeonbuk National University
2018
Toxoplasma gondii can invade and replicate in all nucleated cells a wide range of host species, infection induces IL-1β production. plays central roles the stimulation innate immune system inflammation. However, little is known responses human fetal small intestinal epithelial (FHs 74 Int cells) after T. infection. FHs were infected with GFP-RH strain. Then, production its mechanisms action evaluated using ELISA, MTT cell viability assays, Western blotting, immunofluorescence, quantitative...
A multi-organ-on-a-chip (MOC), also known as a human-on-a-chip, aims to simulate whole body response drugs by connecting microscale cell cultures of multiple tissue types via fluidic channels and reproducing the interaction between them. While several studies have demonstrated usefulness MOC at proof-of-concept level, improvements are needed enable wider acceptance such systems; ease use for general biological researchers, mathematical framework design interpret systems. Here, we introduce...
Oxidative stress, caused by the excessive production of reactive oxygen species (ROS), results in cellular damage. Therefore, functional materials with antioxidant properties are necessary to maintain redox balance. Turmeric leaves (Curcuma longa L. leaves; TL) known have properties, including 2,2-Diphenyl-1-picrylhydrazyl (DPPH), 2,2′-Azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid (ABTS), and Hydrogen peroxide (H2O2) radical scavenging activity several studies. The effects TL come from...
Abstract Polyphenolic compounds were examined for their effects on suppressing adipocyte differentiation in 3T3‐L1 cells. Most polyphenolic inhibited development from cells to some extent. Among them, rutin was the most effective a dosage dependant manner. Activity of glycerol‐3‐phosphate dehydrogenase (GPDH), which has central position lipogenesis adipose cells, also decreased by addition at induction stage. RT‐PCR results demonstrated that mRNA expression adipogenic transcription factors...
The formation of advanced glycation end products (AGE) is linked to the pathogenesis diabetic nephropathy. aim this work was assess therapeutic potential and underlying mechanism action dieckol (DK), isolated from Ecklonia cava, on renal damage induced by methylglyoxal (MGO) in mouse glomerular mesangial cells. antiglycation properties DK were evaluated using ELISA. We conducted molecular docking, immunofluorescence analysis, Western blotting confirm which prevents AGE-related treatment...
The absorption of drugs via oral route is a subject great interest in drug development process. current vitro method for measuring the kinetics relies on 2-D monolayer culture Caco-2 cells porous membrane, but physiologically unrealistic environment provided by this often results inaccurate kinetics. Here we report novel microfluidic system which better mimics physiological human small intestine. Three dimensional geometries villi intestine were reproduced hydrogel microfabrication...
A study was conducted to develop a simple sequential separation protocol separate phosvitin and IgY from egg yolk without using organic solvents. Egg diluted with 2 volumes of distilled water (DW), homogenized, centrifuged. The precipitant collected homogenized 4 10% NaCl (wt/vol) in 0.05 N NaOH solution extract phosvitin. pH the homogenate adjusted 4.0 precipitate removed by centrifugation. supernatant then heat-treated at 70°C for 30 min centrifuged remove impurities. containing collected,...
Interleukin (IL)-23 and IL-12 are closely related in structure, these cytokines regulate both innate adaptive immunity. However, the precise signaling networks that production of each Toxoplasma gondii-infected THP-1 monocytic cells, particularly PI3K/AKT MAPK pathways, remain unknown. In present study, T. gondii infection upregulated expression IL-23 increased with parasite dose. secretion was strongly inhibited by TLR2 monoclonal antibody (mAb) treatment a dose-dependent manner siRNA...
The aim of this study was to improve the anti-inflammatory activities apigenin through co-treatment with resveratrol as a bioenhancer apigenin. RAW 264.7 cells pretreated hepatic metabolites formed by co-metabolism and (ARMs) in HepG2 were stimulated lipopolysaccharide (LPS). ARMs prominently inhibited (p < 0.05) production nitric oxide (NO), prostaglandin E2 (PGE2), interleukin (IL)-1β, IL-6 TNF-α. Otherwise no such activity observed alone (AMs). also effectively suppressed protein...
Enzyme‐catalyzed, ring‐opening polymerization of biodegradable aliphatic polyesters has successfully been applied to surface‐initiated (see Figure). Using lipase B as a catalyst, thin film poly(ϵ‐caprolactone) (PCL) and poly( p ‐dioxanone) (PPDX) on gold substrate (after formation self‐assembled monolayers terminating in hydroxyl groups) is formed.
Toxoplasma gondii is an obligate intracellular parasite that stimulates production of high levels proinflammatory cytokines, which are important for innate immunity. NLRs, i.e., nucleotide-binding oligomerization domain (NOD)-like receptors, play a crucial role as immune sensors and form multiprotein complexes called inflammasomes, mediate caspase-1-dependent processing pro-IL-1β. To elucidate the inflammasome components in T. gondii-infected THP-1 macrophages, we examined...