A5100320189- Seaweed-derived Bioactive Compounds
- Protein Hydrolysis and Bioactive Peptides
- Advanced Glycation End Products research
- Food Quality and Safety Studies
- Biochemical effects in animals
- Bioactive Compounds and Antitumor Agents
- Phytochemicals and Antioxidant Activities
- Agriculture, Soil, Plant Science
- Natural Antidiabetic Agents Studies
- Algal biology and biofuel production
- Fatty Acid Research and Health
- Aquaculture Nutrition and Growth
- Inflammatory mediators and NSAID effects
- Free Radicals and Antioxidants
- Proteins in Food Systems
- Insect Utilization and Effects
- Polysaccharides and Plant Cell Walls
- Nanocomposite Films for Food Packaging
- Aldose Reductase and Taurine
- Pharmacological Effects of Natural Compounds
- Meat and Animal Product Quality
- Cholinesterase and Neurodegenerative Diseases
- Echinoderm biology and ecology
- Alcohol Consumption and Health Effects
- Essential Oils and Antimicrobial Activity
Korea Food Research Institute
2015-2025
Korea University of Science and Technology
2014-2025
University of Pittsburgh
2023
UPMC Hillman Cancer Center
2023
University of Science and Technology
2016
Daejeon University
2016
Pukyong National University
2007-2015
Korea University
2015
Seoul National University
2013
Sejong University
2012
Three phlorotannins, including phloroglucinol, diphlorethohydroxycarmalol, and 6,6′-bieckol, were isolated from Ishige okamurae by column chromatography. The structures of the phlorotannins determined on basis spectroscopic analysis, NMR mass spectrometry (MS) techniques. Antioxidant effects measured direct free radical scavenging activities using electron spin resonance (ESR) technique cellular systems in vitro. results indicated that diphlorethohydroxycarmalol 6,6′-bieckol showed potential...
Abstract BACKGROUND: Diabetes mellitus (DM) is a chronic metabolic disorder characterized by defects in insulin secretion and action, which can lead to damaged blood vessels nerves. With respect effective therapeutic approaches treatment of DM, much effort has being made investigate potential inhibitors against α‐glucosidase α‐amylase from natural products. The edible marine brown alga Ecklonia cava been reported possess various interesting bioactivities, are studied here. RESULTS: In this...
Two bioactive phloroglucinol derivatives, fucodiphloroethol G (1) and phlorofucofuroeckol A (3) were first isolated from Eckolonia cava (EC) characterized by nuclear magnetic resonance (NMR) spectroscopic methods, along with eckol (2). In this study, anti-allergic activities of derivatives assessed on human basophilic leukemia (KU812) rat (RBL-2H3) cell lines using a histamine release assay. Both compounds 1 3 exhibited significant inhibitory activity against release. Meanwhile, the...
Abstract BACKGROUND: In an effort to develop alternative therapeutic agents, strong inhibitory activity against α‐glucosidase and α‐amylase was detected in Eisenia bicyclis methanolic extract. RESULTS: this study, two phlorotannins were isolated from E. characterised by chromatography nuclear magnetic resonance. The active substances identified as fucofuroeckol A (FF) dioxinodehydroeckol (DD). To the authors' knowledge, is first report of identification these . However, date, no antidiabetic...
Oxidative stress, caused by the excessive production of reactive oxygen species (ROS), results in cellular damage. Therefore, functional materials with antioxidant properties are necessary to maintain redox balance. Turmeric leaves (Curcuma longa L. leaves; TL) known have properties, including 2,2-Diphenyl-1-picrylhydrazyl (DPPH), 2,2′-Azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid (ABTS), and Hydrogen peroxide (H2O2) radical scavenging activity several studies. The effects TL come from...
To produce bioactive peptides from by-products of fish processing, bigeye tuna dark muscle was hydrolyzed using various enzymes (alcalase, α-chymotrypsin, neutrase, papain, pepsin, and trypsin), the hydrolysates were evaluated for antioxidant activity. Considering results degree hydrolysis activities, peptic hydrolysate used further studies to identify a potent peptide. Antioxidant peptide purified consecutive chromatographic methods identified as being...
Methicillin-resistant Staphylococcus aureus (MRSA) is spreading worldwide, emphasizing the need to search for new antibiotics. The anti-MRSA activities of gallic acid-grafted-chitosans (GA-g-chitosans) were investigated against 2 MRSA standards and 10 clinical isolates by determining minimum inhibitory concentrations (MICs). GA-g-chitosan (I), which has highest acid content, exhibited strongest activities, with MICs 32–64 μg/mL. A time-kill investigation revealed that (I) a bactericidal...
Ishige okamurae (I. okamuare), an edible brown alga, is rich in isophloroglucin A (IPA) phlorotannin compounds and effective preventing diseases, including diabetes. We evaluated its anti-glycation ability, intracellular reactive oxygen species scavenging activity, inhibitory effect on the accumulation of MGO/MGO-derived advanced glycation end products (AGE), regulation downstream signaling pathways related to AGE–receptor for AGEs (RAGE) interaction. IPA (0.2, 1, 5 μM) demonstrated ability...
Six phlorotannins, isolated from Eisenia bicyclis , were evaluated for antibacterial activity against methicillin‐resistant Staphylococcus aureus (MRSA). The minimum inhibitory concentrations (MIC) of the compounds in range 32 to 64 µg/mL. Phlorofucofuroeckol‐A (PFF) exhibited highest anti‐MRSA activity, with an MIC An investigation interaction between these and β‐lactam antibiotics ampicillin, penicillin, oxacillin revealed synergistic action MRSA combination compound PFF. To our knowledge,...
Cardiovascular diseases are closely related to hypertension, type 2 diabetes mellitus, obesity, and hyperlipidemia. Many studies have reported that an unhealthy diet sedentary lifestyle critical factors enhance these diseases. Recently, many bioactive compounds isolated from marine seaweeds been studied for their benefits in improving human health. In particular, several unique metabolites such as polyphenols, polysaccharides, peptides, carotene, sterol the most effective components...
The formation of advanced glycation end products (AGE) is linked to the pathogenesis diabetic nephropathy. aim this work was assess therapeutic potential and underlying mechanism action dieckol (DK), isolated from Ecklonia cava, on renal damage induced by methylglyoxal (MGO) in mouse glomerular mesangial cells. antiglycation properties DK were evaluated using ELISA. We conducted molecular docking, immunofluorescence analysis, Western blotting confirm which prevents AGE-related treatment...
In the exploration of abundant marine biological resources, edible red alga Laurencia undulata led to two bioactive isolates: floridoside (1) and D-isofloridoside (2). For first time, antioxidant properties both derivatives (1 2) were characterized via free radical scavenging using ESR technique, reactive oxygen species (ROS) inhibition, membrane protein oxidation, myeloperoxidase (MPO) gene expression levels glutathione (GSH) superoxide dismutase (SOD), MMP-2 MMP-9. The results demonstrate...