A5080596529- Plant Molecular Biology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Immune cells in cancer
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Plant Stress Responses and Tolerance
- Plant nutrient uptake and metabolism
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- COVID-19 diagnosis using AI
- Pancreatic and Hepatic Oncology Research
- Artificial Intelligence in Healthcare and Education
- Organ Transplantation Techniques and Outcomes
- Genomics and Chromatin Dynamics
- Radiomics and Machine Learning in Medical Imaging
- Cancer Research and Treatments
- Nanoplatforms for cancer theranostics
- Viral-associated cancers and disorders
- Plant-Microbe Interactions and Immunity
- Machine Learning and Data Classification
- Plant Disease Management Techniques
- Insect and Pesticide Research
- RNA Research and Splicing
Beijing Tsinghua Chang Gung Hospital
2017-2025
Tsinghua University
2019-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Center for Excellence in Molecular Plant Sciences
2017-2021
Chinese Academy of Sciences
2013-2021
University of North Carolina at Chapel Hill
2021
University of Chinese Academy of Sciences
2018
Lanzhou University
2012-2014
The sudden outbreak of novel coronavirus 2019 (COVID-19) increased the diagnostic burden radiologists. In time an epidemic crisis, we hoped artificial intelligence (AI) to help reduce physician workload in regions with outbreak, and improve diagnosis accuracy for physicians before they could acquire enough experience new disease. Here, present our building deploying AI system that automatically analyzes CT images detect COVID-19 pneumonia features. Different from conventional medical AI,...
Grafting is an ancient cloning method that has been used widely for thousands of years in agricultural practices. Graft-union development also intricate process involves substantial changes such as organ regeneration and genetic material exchange. However, the molecular mechanisms graft-union are still largely unknown. Here, a micrografting Arabidopsis was improved to adapt it smooth procedure facilitate sample analysis allow easily be applied various dicotyledonous plants. The developmental...
Significance The histone 3 lysine 9 demethylase Increase in BONSAI Methylation 1 (IBM1) is critical for preventing CHG (H=A, T, or C) methylation plant genes. We found that the putative chromatin regulator Enhanced Downy Mildew 2 (EDM2) controls genome and transgene silencing by regulating alternative polyadenylation of IBM1 . EDM2 contains a composite homeo domain simultaneously recognizes both repressive active marks, allowing it to associate specifically with intronic heterochromatin...
Arabidopsis PICKLE (PKL) is a putative CHD3-type chromatin remodeling factor with important roles in regulating plant growth and development as well RNA-directed DNA methylation (RdDM). The role of PKL protein abiotic stress response still poorly understood. Here, we report that for cold Arabidopsis. Loss-of-function mutations the gene lead to chlorotic phenotype seedlings under stress, which caused by alterations transcript levels some chlorophyll metabolism-related genes. pkl mutant also...
Transarterial chemoembolization (TACE) stands for an ideal therapy patients with intermediate stage HCC. This study was carried out to observe the effect of microparticles-transarterial (microparticles-TACE, m-TACE) on immune function hepatocellular carcinoma (HCC) by detecting proportion regulatory (Treg) cells in peripheral blood HCC before and after m-TACE, determine whether m-TACE has a positive patients.33 treated Gelatn Sponge Microparticles (GSMs-TACE) were enrolled. Flow cytometry...
Aiming at the problem of how to select best algorithm for a given classification problem, meta-learning and Bi-Tier selection based classifier recommendation (MLBCR) is proposed. Firstly, set meta-features extracted characterize dataset by combining meta-learning. Secondly, comprehensive evaluation index proposed comprehensively evaluate performance 11 candidate algorithms on each dataset, with defined as dataset. Then, meta-feature vector corresponding training are stored in MySQL database...
Abstract Heterochromatin is widespread in eukaryotic genomes and has diverse impacts depending on its genomic context. Previous studies have shown that a protein complex, the ASI1‐AIPP1‐EDM2 (AAE) participates polyadenylation regulation of several intronic heterochromatin‐containing genes. However, genome‐wide functions AAE are still unknown. Here, we show ASI1 EDM2 mostly target common regions level preferentially interacts with genetic heterochromatin. Polyadenylation (poly(A) sequencing...
New treatment strategies are needed to improve outcomes for patients with advanced cholangiocarcinoma (CCA) due the limited efficacy of current first-line chemotherapy regimens. Although combination hepatic arterial infusion (HAIC), lenvatinib, and programmed cell death protein-1 (PD-1) inhibitors has been extensively evaluated in hepatocellular carcinoma, their roles CCA remain poorly understood. The purpose this study is compare safety HAIC plus lenvatinib or without PD-1 CCA.Between March...
This study aimed to compare efficacy and safety of HepaSpheres CalliSpheres in unresectable large hepatocellular carcinoma (HCC) patients. One hundred twenty-seven HCC patients receiving drug-eluting bead transarterial chemoembolization (DEB-TACE) treatment with or microspheres were analyzed. Treatment response, Karnofsky performance status (KPS) score, adverse events, main liver function indexes, time progression (TTP), overall survival (OS) Objective response rate (82.7% vs. 63.8%, p=.030)...
Turfgrass are widely cultivated ornamental plants that have important ecological, societal and economical values. However, many turfgrass species susceptible to drought demand frequent irrigation thus consuming large amounts of water. With the ultimate goal improving resistance in turfgrass, we identified several ABA receptors mediate signaling stress response. The receptor FePYR1 from Festuca elata was demonstrated bind as a monomer. Crystal structure analysis revealed recognizes binds by...
Hyperbilirubinemia is a major barrier to anti-tumor treatment in patients with end-stage primary liver cancer. However, no research has demonstrated the efficacy and safety of hepatic artery infusion chemotherapy (HAIC) cancer hyperbilirubinemia. This study investigated HAIC modified oxaliplatin, fluorouracil, leucovorin (mFOLFOX) regimen. The regimen was evaluated optimal conditions for further treatments were identified.A total 34 hyperbilirubinemia (with an elevation more than three times...
Myeloid-derived suppressor cells (MDSCs) play a pivotal role in immunosuppression and tumor progression hepatocellular carcinoma (HCC). While various treatments like surgical resection, ablation, radiotherapy have been studied for their effects on circulating MDSC frequencies HCC patients, the findings remain inconclusive. Transarterial Chemoembolization (TACE) stands as standard care unresectable HCC, with Microparticle TACE (mTACE) gaining prominence its capacity to induce significant...
The purpose of this investigation is to present a preliminary clinical experience in transarterial chemoembolization (TACE) with gelatin sponge microparticles (GSMs) for barcelona clinic liver cancer (BCLC) Stage C and large hepatocellular carcinoma (HCC) patients China.Between August 2009 2012, 20 BCLC HCC tumor size ≥5 cm undergoing GSMs-TACE were retrospectively analyzed. Tumor response was evaluated using modified evaluation criteria solid tumors (mRECIST) enhanced magnetic...
A series of clinical studies have established the safety and efficacy transcatheter arterial chemoembolization (TACE) with gelatin sponge microparticles (GSMs) in treating hepatocellular carcinoma (HCC). HCC can lead to obvious necrosis inside tumors, especially larger ones, although it is unclear whether such necrotic tumor tissue induce favorable immune reactions against tumor. Myeloid-derived suppressor cells (MDSCs) immunosuppressive functions are currently considered a very important...
e16265 Background: Hepatic arterial infusion chemotherapy (HAIC) is a well-established treatment for liver cancer. Our previous studies have demonstrated the effectiveness of HAIC with modified FOLFOX (mFOLFOX) intrahepatic cholangiocarcinoma. However, mass-forming cholangiocarcinoma (IMCC) patients often lose therapeutic opportunity due to obstructive jaundice caused by huge tumor compression. On other hand, recombinant human adenovirus type 5 Injection (H101), an oncolytic virus (OVs), has...
At present, breast cancer is the largest malignant tumor endangering women’s health, and has become one of most common types in world. In recent years, relationship between psychosocial factors incidence attracted extensive attention. Traditional Chinese medicine research motherland suggests that emotional disorder an important factor leading to cancer, theory negative accumulation have something some aspects. This article reviews impact emotions on risk current progress explores possibility...
Biliary tract tumors (BTC) account for about 3% of all digestive system tumors, with rising incidence and limited treatment options, particularly advanced stages, underscoring the need innovative therapies. This retrospective cohort study evaluated safety efficacy a novel regimen combining hepatic artery infusion chemotherapy 5-fluorouracil, leucovorin, oxaliplatin (mFOLFOX-HAIC) alongside lenvatinib programmed cell death protein-1 (PD-1) inhibitors (mFOLFOX-HAIC+lenvatinib+PD-1i) compared...
To compare the efficacy and safety of iodized oil versus polyvinyl alcohol (PVA) particles in portal vein embolization (PVE) before partial hepatectomy. From October 2016 to December 2021, 86 patients who planned undergo hepatectomy after PVE were enrolled, including 61 post-PVE with PVA + coils 25 coils. All underwent CT examination 2–3 weeks evaluate future liver remnant (FLR). The intercohort comparison included degree volume growth, changes laboratory data, adverse events. There was no...
Hypersplenism is a serious complication of portal hypertension in liver cirrhosis, which difficult problem for the treatment this kind patients. Partial splenic embolization (PSE) safe, effective, reproducible, minimally invasive, and able to retain partial immune function spleen hypersplenism. Transcatheter arterial chemoembolization (TACE) has played pivotal role hepatocellular carcinoma with The mechanism primary hypersplenism, embolization, operation method postoperative complications...