A5100682730- Natural product bioactivities and synthesis
- Lung Cancer Diagnosis and Treatment
- Cancer Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Gut microbiota and health
- RNA modifications and cancer
- Gastrointestinal Tumor Research and Treatment
- CAR-T cell therapy research
- Pharmacological Effects of Natural Compounds
- Click Chemistry and Applications
- HIV Research and Treatment
- Inflammatory Bowel Disease
- Ophthalmology and Visual Impairment Studies
- Synthesis and Biological Evaluation
- Barrier Structure and Function Studies
- Medicinal Plant Pharmacodynamics Research
- Ferroptosis and cancer prognosis
- Ocular Surface and Contact Lens
- Gallbladder and Bile Duct Disorders
- Viral Infectious Diseases and Gene Expression in Insects
- Oral microbiology and periodontitis research
- Synthesis and biological activity
- Esophageal Cancer Research and Treatment
- Synthesis and Characterization of Heterocyclic Compounds
- Lymphatic System and Diseases
AstraZeneca (United States)
2023
Nanjing University
2023
Zhoushan Hospital
2010-2022
Wuhan University
2008-2021
Renmin Hospital of Wuhan University
2008-2021
Beijing Institute of Genomics
2011
Chinese Academy of Sciences
2011
Intercellular proximity labeling has emerged as a promising approach to enable the study of cell-cell interactions (CCIs), but efficiency current platforms is limited. Here, we use Ru(bpy)32+ construct an efficient photocatalytic (PPL) system on cell surface that allows highly discriminative CCI detection with spatiotemporal resolution. Through mechanism and quantitative characterization living cells, demonstrate singlet-oxygen (1 O2 ) more specific than single electron transfer (SET) in...
Clostridium butyricum (CB), a probiotic, is gram-positive obligate anaerobic bacillus with acid and heat resistant properties. Previous studies have reported that CB has beneficial effects in intestinal diseases regulates function. The aim of the present study was to investigate protective mechanisms on barrier Mice were randomly divided into three experimental groups (n=15 mice/group), including control, dextran sodium sulfate (DSS) DSS + CB. In colitis induced 3% dissolved drinking water...
Recent evidence suggests that a small subset of cells within tumors have ‘stem cell-like’ characteristics. However, direct proof the population liver CSCs remains elusive. Further research is needed to identify with stem cell properties in established HCC lines. Our previous investigation found tumor spheres are essentially enriched CSCs. We hypothesized chemoresistance hepatocellular carcinoma (HCC) due enrichment cancer via PI3K/Akt pathway. formed from contained high percentage CD90+...
The present study aimed to investigate the roles of cancer-associated fibroblasts (CAFs), matrix metalloproteinase-9 (MMP-9) and lymphatic vessel density (LVD) during progression from adenocarcinoma in situ (AIS) invasive lung (IAC). A total 77 patients with stage 0-IA were enrolled. expression levels α-smooth muscle actin, MMP-9 D2-40 immunohistochemically analyzed. Survival analysis was performed using Kaplan-Meier method. In non-invasive component, proportion CAFs increased AIS IAC;...
Lung adenocarcinoma (LUAD) is a highly aggressive cancer in advanced stages and has the highest cancer-related death across world. Anoikis emerged as specific form of apoptotic cell that may play vital role formation development tumors.Based on The Cancer Genome Atlas dataset, we developed novel anoikis-related genes (ARGs) signature LUAD evaluated differences between low high-risk groups clinical characteristics, expression patterns, immune infiltration, drug sensitivity, etc. According to...
Background: Capsule endoscopy (CE) and double-balloon enteroscopy (DBE) have provided great help in the diagnosis treatment of small bowel diseases (SBD). The aim this study was to explore positive rate diagnostic value CE DBE for patients who were suspected having SBD, make a comparison between two methods. Methods: A retrospective conducted analyze cases at Renmin Hospital Wuhan University. We divided into group, recorded basic characteristics patients, checking results DBE, rate,...
Abstract Background Small incision lenticule extraction (SMILE) is a popular procedure for correcting myopia and myopic astigmatism; however, the cornea thins to varying degrees following SMILE surgery, its postoperative stability may be affected. We investigated safety efficacy of in patients with high analyzed factors influencing corneal posterior elevation variation (PCE). Methods This was prospective non-randomized clinical study. Patients thickness < 530 µm at thinnest point right...
<h3>Background</h3> Recent clinical trials have shown the potential therapeutic benefit of combining durvalumab (anti-PD-L1) with ataxia telangiectasia and rad3-related (ATR) protein inhibitor ceralasertib (AZD6738).<sup>1 2</sup> Here, we characterized effect on T cells, tumor cancer-associated fibroblasts (CAFs) <i>in vitro</i> to understand how may synergize anti-PD-L1 in modulating various aspects immune biology. <h3>Methods</h3> To determine CD8 T-cells, melanoma dissociated cells...