In hemodialysis patients extracellular fluid overload is a predictor of all-cause and cardiovascular mortality, relation with inflammation has been reported in previous studies. The magnitude nature this interaction the effects moderate depletion on survival are still unclear. We present results an international cohort study 8883 from European MONDO initiative database where, during three-month baseline period, status was assessed using bioimpedance by C-reactive protein. All-cause mortality...

Introduction Idiopathic pulmonary fibrosis (IPF) is characterized by progressive lung dysfunction due to excessive collagen production and tissue scarring. Despite recent advancements, the molecular mechanisms remain unclear. Methods RNA sequencing identified 475 differentially expressed genes (DEGs) in TGF-β1-induced primary model. Gene expression chips GSE101286 GSE110147 from NCBI gene omnibus (GEO) database were analyzed using GEO2R, revealing 94 DEGs IPF samples. The ontology (GO)...

Cardiovascular (CV) events are increased 36-fold in patients with end-stage renal disease. However, randomized controlled trials to lower LDL cholesterol (LDL-C) and serum total (TC) have not shown significant mortality improvements. An inverse association of TC LDL-C all-cause CV has been observed on chronic dialysis. Lipoproteins also may protect against infectious diseases. We used data from 37,250 the international Monitoring Dialysis Outcomes (MONDO) database evaluate between lipids...

Intradialytic hypoxemia has been recognized for decades, but its associations with outcomes have not yet assessed in a large patient cohort.Our retrospective cohort study was conducted between January of 2012 and 2015. We recorded blood oxygen saturation every minute during hemodialysis patients arteriovenous access. A 6-month baseline period at least 10 treatments measurements preceded 12-month follow-up. Patients were stratified by the presence or absence prolonged intradialytic defined as...

Abstract Background Hypoxia in the vicinity of bone defects triggers osteogenic differentiation precursor cells and promotes healing. The activation STAT3 signaling mesenchymal stem (MSCs) has similarly been reported to mediate regeneration. However, interaction between hypoxia during defect healing is still unknown. Methods In this study, we assessed impact different durations CoCl 2 -induced cellular on MSCs. Role induced was analyzed both vitro vivo. vivo investigated a mouse femoral...

Abstract Background Protein-energy wasting, muscle mass (MM) loss and sarcopenia are highly prevalent associated with poor outcome in haemodialysis (HD) patients. Monitoring of MM and/or metabolism HD patients is paramount importance for timely detection to intervene adequately. In this study we assessed the reliability reproducibility a simplified creatinine index (SCI) as surrogate marker explored its predictive value on outcome. Method We included all in-centre from 16 European countries...

To explore the role of self-efficacy (SE) in effect patient empowerment on self-management behaviours among patients with chronic illness and to investigate moderating three types health locus control (HLC) this moderated mediation model.Cross-sectional design.Data were collected a general tertiary hospital, sample 254 was recruited between August October 2020. The moderation tested by PROCESS macro (Model 4 Model 8) for SPSS 25.0 Hayes using 5000 bootstrap samples.Self-efficacy...

<b><i>Background/Aims:</i></b> Hemodialysis (HD) patients are less active than their healthy counterparts and frequently experience poor sleep. Our aims were to objectively quantify activity sleep quality in HD of an urban population determine the effect providing feedback on activity. <b><i>Methods:</i></b> Activity parameters collected by a commercially available tracker 29 chronic patients. Patients group provided with data during each...

<b><i>Background/Aims:</i></b> Hemodialysis (HD) patients are less active than their healthy counterparts. They often plagued with sleep disorders that affect the quality of sleep. Our aim was to objectively quantify activity and among HD in a suburban population. <b><i>Methods:</i></b> Activity parameters were measured using commercially available tracker 29 from Baton Rouge, LA, USA. Patients feedback group received data at each dialysis...

<b><i>Background/Aims:</i></b><i></i> Neighborhood walkability is associated with indicators of health in the general population. We explored association between neighborhood and daily steps hemodialysis (HD) patients. <b><i>Methods:</i></b><i></i> measured over 5 weeks using Fitbit Flex (Fitbit, San Francisco, CA, USA) retrieved Walk Score® (WS) data by patient’s home ZIP code (www.walkscore.com; 0 = poorest...

<b><i>Background:</i></b> Low serum sodium (SNa) is associated with an increased mortality in chronic hemodialysis (HD) patients. Dialysis patients are thought to have individual pre-dialysis SNa set-point, yet there evidence for variability of patient. In this study, we explored the association several metrics all-cause a large patient population from international MONitoring Outcomes (MONDO) Initiative. <b><i>Methods:</i></b> All adult...

Abstract Background Evidence indicates that the inverse relationships between phosphate levels and mortality maybe modified by age. Furthermore, malnutrition inflammation could strengthen risk associated with abnormalities. This study aimed to assess associations while accounting for interactions age parameters in hemodialysis (HD) patients. Methods Adult HD patients (n = 245 853) treated Fresenius Medical Care North America clinics from January 2010 October 2018 were enrolled. Baseline was...

Background The study aimed to clarify whether the rtI233V substitution affects adefovir (ADV) resistance. Methods A total of 18,419 patients from Beijing 302 Hospital were investigated. HBV complete reverse transcriptase region polymerase was screened by direct sequencing and verified clonal if necessary. Replication-competent wild-type mutant genomic amplicons transfected into HepG2 cells for phenotypic analysis viral replication capacity drug susceptibility. Results detected in 38/5,344...

Key Points We conducted a randomized controlled pilot trial in patients on hemodialysis using physiology-based individualized anemia therapy assistance software. Patients the group receiving erythropoiesis-stimulating agent dose recommendations from novel software showed improvement hemoglobin stability and utilization. Background Anemia is common among hemodialysis. Maintaining stable levels within predefined target can be challenging, particularly with frequent fluctuations both above...

We report on the design, fabrication, and characterization of an interband cascade laser (ICL) array incorporating multimode interference (MMI) couplers for phase-locking emitters. The ICL array, emitting at 3-4 µm, was developed to address challenges heat dissipation in-phase operation in mid-infrared lasers. features a 7.5-µm-wide ridge design fundamental transverse mode propagation employs MMI structures realize multiple far-field patterns, characterized by periodic symmetrical fringes,...

The strong anisotropic forbidden transition has been observed in a series of InGaAs/GaAs single-quantum well with width ranging between 3 nm and 7 at 80 K. Numerical calculations within the envelope function framework have performed to analyze origin optical transition. It is found that anisotropy this can be mainly attributed indium segregation effect. effect uniaxial strain on in-plane (IPOA) also investigated. IPOA changes little strain, while allowed shows linear dependence strain.PACS...

InAs/GaSb type II superlattices were grown on (100) GaSb substrates by metalorganic chemical vapor deposition (MOCVD). A plane of mixed As and Sb atoms connecting the InAs layers was introduced to compensate tensile strain created layer in SL. Characterizations samples atomic force microscopy high-resolution X-ray diffraction demonstrate flat surface morphology good crystalline quality. The lattice mismatch approximately 0.18% between SL substrate is small compared MOCVD-grown supperlattice...

We demonstrate a quantum dot cascade photodetector with hybrid active region of InAs dots and an InGaAs well, which exhibited temperature independent response at 4.5 μm. The normal incident responsivity reached 10.3 mA/W 120 K maintained value 9 up to 260 K. It specific detectivity above 1011 cm Hz1/2 W−1 77 K, remained 108 ascribe the device's good thermal stability infrared three-dimensional confinement incorporated in region.

One of the most prominent characteristics bisphosphonate-related osteonecrosis jaw(BRONJ) is its site-specificity. Osteonecrosis tends to occur specifically in maxillofacial bones, spite a systemic administration medicine. Previous studies suggested rich blood supply and fast bone turnover might be reasons for BRONJ. Yet, sound scientific basis explaining occurrence still lacking. The present study aimed explore role Porphyromonas gingivalis ( P. ), an important oral pathogen, on...

Objective. Transplantation of bone marrow-derived mesenchymal stem cells (BMSCs) remains a hopeful therapeutic approach for defect reconstruction. Herein, we investigated the effects and mechanisms leukemia inhibitory factor (LIF) in function viability hypoxic BMSCs as well repair. Methods. The LIF on apoptosis (flow cytometry, TUNEL staining), mitochondrial activity (JC-1 proliferation (colony formation, EdU differentiation (CD105, CD90, CD29 via flow sorting) were examined BMSCs. LIF,...