A5100351137- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- HIV/AIDS drug development and treatment
- Hepatitis Viruses Studies and Epidemiology
- Viral Infections and Outbreaks Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Bacteriophages and microbial interactions
- Asthma and respiratory diseases
- Cytomegalovirus and herpesvirus research
- Dermatologic Treatments and Research
- Carbohydrate Chemistry and Synthesis
- Distributed and Parallel Computing Systems
- Advanced Data Storage Technologies
- Epigenetics and DNA Methylation
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Cells and Metastasis
- Allergic Rhinitis and Sensitization
- Animal Virus Infections Studies
- Neonatal and fetal brain pathology
- Head and Neck Cancer Studies
- Inflammatory mediators and NSAID effects
- Cardiac electrophysiology and arrhythmias
- Immune Response and Inflammation
- Chemical Synthesis and Reactions
Shaanxi Normal University
2025
Huazhong University of Science and Technology
2015-2024
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2024
Chinese PLA General Hospital
2019-2024
Hangzhou Center for Disease Control and Prevention
2015-2024
Anhui University of Traditional Chinese Medicine
2024
Chongqing Medical University
2024
Hubei Cancer Hospital
2022-2024
Anhui Medical University
2024
Loma Linda University
2024
The objective of this study was to determine the association 19 mutations with frequencies ≥ 10% in core promoter region hepatitis B virus (HBV) chronic (CHB), liver cirrhosis, and hepatocellular carcinoma (HCC).Eight hundred forty-six asymptomatic surface antigen carriers (ASCs), 235 CHB patients, 188 cirrhosis 190 HCC patients intact data HBV genotyping, DNA sequencing, serological parameters were studied. Nucleotides highest genotypes C from all ASCs treated as wild-type...
Abstract Purpose: Tumor metastasis continues to be the major obstacle cancer therapy and leading cause of cancer-related death. Methods used detect metastasis, especially occult metastases, have received a great deal attention. In this study, novel selective peptide was assessed for its specific binding metastasis. Methods: The FliTrx bacterial display system, an alternative phage display, identify 5-amino acid termed TMTP1 (NVVRQ), which binds highly metastatic prostate cell line PC-3M-1E8....
Cholangiocarcinoma (CCA) is a highly malignant bile duct cancer that tends to invade and metastasize early. The epithelial–mesenchymal transition (EMT) has been implicated in cell invasion metastasis, as well evasion of host immunity. In this study, we investigated the interaction between atypical protein kinase C‐iota (aPKC‐ι) Snail regulation EMT its relationship CCA immunosuppression. Our results demonstrated aPKC‐ι, Snail, infiltrated immunosuppressive cells were significantly...
S-glycosides, S-2-(2-propylthio)benzyl (SPTB) glycosides, were converted to the corresponding oxidized glycosyl donors, S-2-(2-propylsulfinyl)benzyl (SPSB) by simple and selective oxidation. Treatment of disarmed SPSB donor various acceptors with triflic anhydride provided desired glycosides in good excellent yields. Meanwhile, observation thiosulfinate, thiosulfonate, disulfide suggested that leaving group was activated via an interrupted Pummerer reaction. The thioglycosyl donors could be...
Growing evidence shows an association between chronic liver inflammation and hepatocellular carcinoma (HCC) development. STAT3, which is associated with cellular transformation, constitutively activated in human HCC tissues but not normal tissues. Although interleukin-6 (IL-6) elevated the serum of patients HCC, it fully understood whether STAT3 constitutive activation positively correlated autocrine IL-6 secreted by cells. Here, we reported that cells, levels both receptor (IL-6R, gp80),...
Summary Background CD 8 + T cells are important effectors of cell‐mediated immunity; however, their contribution to the pathogenesis CRS is unclear. Objective This study aimed characterize cytokine‐producing features and cytotoxic activity cells, correlation with inflammation patterns in nasal polyps. Methods The expression IFN ‐γ, IL ‐4, ‐5, ‐17A, forkhead box P3 ( FOXP 3), perforin, granzyme B was studied by means flow cytometry, immunohistochemistry, immunofluorescence. T‐cell subset...
This study was aimed at evaluating the clinical significance of serum HBV RNA, hepatitis B core-related antigen (HBcrAg) and core antibody (anti-HBc) levels in chronic patients with undetectable DNA during nucleoside/nucleotide analogue (NA) treatment.Fifty-seven who received long-term NA treatment median 5.83 (25%, 75% percentiles 4.67, 7.75) years were enrolled, 285 samples five time points for each patient quantitatively analysed three markers together surface (HBsAg) levels.The RNA level...
The incidences of early term and late preterm birth have increased worldwide during recent years. However, there is a lack prospective study about the influence on infants' neurodevelopment, especially at stage. Therefore, we conducted this cohort to investigate impact neurodevelopment within 6 months.This was in Wuhan, China, between October 2012 September 2013. A total 4243 singleton infants born 34-41 weeks gestation Wuhan Children's Hospital were included. Gesell Developmental Scale...
We aimed to study the prevalence and clinical implications of hepatitis B virus (HBV) subgenotypes in Chinese patients. A total 4,300 patients, mainly from northern China, were enrolled, including 182 patients with acute 4,118 chronic HBV infection who had been exposed nucleoside or nucleotide analogs. genotypes/subgenotypes determined by direct sequencing S/Pol region. The rates 0.40% for HBV/B1, 14.30% HBV/B2, 0.25% HBV/B3, 0.35% HBV/B4, 1.05% HBV/C1, 81.72% HBV/C2, 0.93% HBV/C3, 0.16%...
The treatment of cancer such as oligonucleotides or peptides requires efficient delivery systems. A novel peptide, TMTP1, previously derived and identified in our laboratory showed remarkable ability to target highly metastatic tumors both vitro vivo, even at the early stage occult metastasis foci. TMTP1 moderately inhibited tumor cell viability, although not enough deem it an killer cells. In this study, we sought enhance anti-tumor activity TMTP1. To do this, fused antimicrobial...
Mother-to-child transmission is the major cause of chronic hepatitis B virus (HBV) infection. This double-blind trial tested effect tenofovir disoproxil fumarate (TDF) in preventing vertical transmission. Pregnant women who were HBsAg/HBeAg-positive with a HBV DNA titer ≥ 2×106 IU/mL randomly assigned to control (n = 60) and TDF-treated groups. TDF treatment (oral dose 300 mg/day) was initiated at 24 weeks gestation continued 4 after delivery. The subjects followed up 28 postpartum. effects...