A5100704360- Liver Disease Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Cancer, Lipids, and Metabolism
- Cervical Cancer and HPV Research
- Colorectal and Anal Carcinomas
- Angiogenesis and VEGF in Cancer
- Colorectal Cancer Surgical Treatments
- Electrospun Nanofibers in Biomedical Applications
- Acute Lymphoblastic Leukemia research
- Global Cancer Incidence and Screening
- Genital Health and Disease
- Electrochemical sensors and biosensors
- Preterm Birth and Chorioamnionitis
- Lipid metabolism and biosynthesis
- Parkinson's Disease Mechanisms and Treatments
- Pregnancy-related medical research
- Hormonal Regulation and Hypertension
- Abdominal Surgery and Complications
- Esophageal and GI Pathology
- Cancer, Hypoxia, and Metabolism
- Hepatitis C virus research
- Ferroptosis and cancer prognosis
Shanghai Cancer Institute
2024
Shanghai Jiao Tong University
2024
Peking University First Hospital
2021-2023
Peking University
2021-2023
Huazhong University of Science and Technology
2017-2023
Wuhan Children's Hospital
2017-2023
Binzhou University
2023
Binzhou Medical University
2023
Fujian Provincial Cancer Hospital
2023
Fujian Medical University
2023
The incidences of early term and late preterm birth have increased worldwide during recent years. However, there is a lack prospective study about the influence on infants' neurodevelopment, especially at stage. Therefore, we conducted this cohort to investigate impact neurodevelopment within 6 months.This was in Wuhan, China, between October 2012 September 2013. A total 4243 singleton infants born 34-41 weeks gestation Wuhan Children's Hospital were included. Gesell Developmental Scale...
Although the importance of macrophages in nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) has been recognized, how affect hepatocytes remains elusive. Mineralocorticoid receptor (MR) implicated to play important roles NAFLD T2DM. However, cellular molecular mechanisms are largely unknown. We report that myeloid MR knockout (MRKO) improves glucose intolerance, insulin resistance, hepatic steatosis obese mice. Estrogen signaling is sufficient necessary for such...
Abstract To assess the relationship between gestational weight gain (GWG) of twin-pregnancy women and twin birth weights, as well to evaluate whether pre-pregnancy body mass index (BMI) influences this relationship. A cohort study was conducted in Wuhan, China, 1/01/2011 8/31/2017. Women with pregnancies who delivered live non-malformed twins were included (6,925 13,850 infants), based on Wuhan Maternal Child Health Management Information System. Logistic regression models employed examine...
Parkinson's disease (PD) is a severe neurodegenerative and there great need for developing biochemical detection method to precisely diagnose it. Alpha-synuclein (α-syn) participates in the main pathology of PD serves as an important biomarker PD. Here, we identified peptoid ASBP-7 that had high affinity specificity α-syn by screening library using high-throughput surface plasmon resonance imaging method. We confirmed could significantly distinguish sera from normal ones through identifying...
Background: Red signs are closely related to esophageal variceal bleeding, and, despite improvements in therapy, the mortality rate remains high. We aimed identify non-invasive predictors of varices and red patients with hepatitis B virus-related liver cirrhosis. Methods: This retrospective study included 356 cirrhosis after applying inclusion exclusion criteria among 661 patients. All underwent endoscopy, ultrasonography, laboratory examinations, computed tomography/magnetic resonance...
Prostate cancer is a significant clinical issue, particularly for high Gleason score (GS) malignancy patients. Our study aimed to engineer and validate risk model based on the profiles of high-GS PCa patients early identification prediction prognosis.We conducted differential gene expression analysis patient samples from The Cancer Genome Atlas (TCGA) enriched our understanding functions. Using least absolute selection shrinkage operator (LASSO) regression, we established validated it using...
Although vomiting in the first trimester has been reported to be associated with preterm birth (PTB), findings supporting this association remain inconsistent. Our aim was assess between and PTB, as well evaluate if is modified by pre-pregnancy body mass index (BMI). A retrospective cohort study. Wuhan, a central city of China. total 317 463 pregnant women who had live, singleton newborn from 1 January 2010 23 May 2016 were enrolled our PTB defined gestational age <37 weeks. Gestational...
Anthocyanin has attracted increasing attention due to its superior biological activity. However, the inherently poor stability of anthocyanin limits practical applications. In this study, a fast and straightforward method was developed improve anthocyanin. Cellulose acetate ultrafine fiber-loaded (CA@Anthocyanin UFs) prepared by robust electrospinning, potential application cellulose fibers (CA as bioactive substance delivery system comprehensively investigated. The experimental results...
Background It is not known which risk stratification system has the best discrimination ability for predicting prostate cancer death. Methods We identified patients with non-metastatic primary adenocarcinoma diagnosis between 2004 and 2015 using Surveillance, Epidemiology, End Results database. Patients were categorized in different groups three frequently used systems of National Comprehensive Cancer Network guideline (NCCN-g), American Urological Association (AUA-g), European Urology...
Objective To evaluate whether twin zygosity influences the association between neonatal outcomes and gestational weight gain (GWG) based on Chinese guidelines in twin-pregnancy women. Design A retrospective cohort study. And it is not a clinical trial. Setting Women with pregnancies living Wuhan, China. Participants total of 5140 women who delivered live non-malformed twins from 1 January 2011 to 31 August 2017 were included this Main outcome measure The primary paired small for age (SGA,...
Anastomotic leakage is a life-threatening complication. Improvement of the anastomosis technique needed, especially in patients with an inflamed edematous intestine. The aim our study was to evaluate safety and efficacy asymmetric figure-of-eight single-layer suture for intestinal pediatric patients.A total 23 underwent at Department Pediatric Surgery Binzhou Medical University Hospital. Demographic characteristics, laboratory parameters, time, duration nasogastric tube placement, day first...
OBJECTIVE To investigate the clinicopathological significance of p16(INK4A) expression and DNA ploidy status in HPV-negative uterine cervical cancers their precursors. METHODS lesions, including 20 cases cervicitis, intraepithelial neoplasm (CIN), 3 glandular (CGIN), 38 invasive squamous cell carcinoma (SCCs) 15 adenocarcinoma were selected subject to screening for HPV infection by PCR method. The protein studied immunohistochemistry flow cytometry respectively. RESULTS Specific was seen...
Objective To analyze the application value of evidence-based nursing(EBN) in LASEK surgery. Methods Totals 120 cases LASIK surgery patients from December 2013 to 2015 were selected, and divided into observation group control by sortition. Patients received EBN, while routine nursing. Systolic blood pressure(SBP), diastolic pressure(DBP), heart rate, SAS score before surgery, postoperative complications after 1 week, visual acuity, diopter intraocular pressure 4 weeks, Haze grading are...
The serum protein markers of colorectal adenoma in patients with a family history cancer have been rarely reported.Serum samples from or without and healthy controls were profiled using Matrix-Assisted Laser Desorption/Ionization Time Flight Mass Spectrometry (MALDI-TOF-MS).The model to distinguish atypical hereditary families (CRA-H) sporadic (CRA-S) was established 85.0% accuracy.The distinguishing CRA-H individuals 90.0% specificity 86.7% sensitivity.Additionally, five peaks (2202, 5821,...