A5100447977- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Chronic Lymphocytic Leukemia Research
- Hepatitis B Virus Studies
- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Adipokines, Inflammation, and Metabolic Diseases
- Natural Compounds in Disease Treatment
- Hepatitis C virus research
- Coronary Interventions and Diagnostics
- Wnt/β-catenin signaling in development and cancer
- Cancer-related Molecular Pathways
- Adipose Tissue and Metabolism
- Rheumatoid Arthritis Research and Therapies
- Inflammasome and immune disorders
- Autophagy in Disease and Therapy
- Monoclonal and Polyclonal Antibodies Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Viral-associated cancers and disorders
- Cancer-related molecular mechanisms research
- Skin and Cellular Biology Research
- Pharmacological Effects of Natural Compounds
- Cardiac Ischemia and Reperfusion
- Pain Mechanisms and Treatments
- Autoimmune and Inflammatory Disorders Research
Chengdu Normal University
2025
Sichuan University
2025
Capital Medical University
2015-2025
First Affiliated Hospital of Xi'an Jiaotong University
2025
Shaoxing People's Hospital
2025
Beijing Ditan Hospital
2015-2025
Children's Mercy Hospital
2016-2024
National University of Defense Technology
2024
University of Missouri–Kansas City
2017-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2024
Hyperglycemia is a major independent risk factor for diabetic macrovascular disease. The consequences of exposure endothelial cells to hyperglycemia are well established. However, little known about how adipocytes respond both acute as chronic physiological levels hyperglycemia. Here, we analyze exposed in vitro vivo. Comparing differentiated at 4 mm 25 glucose (the standard differentiation protocol) reveals severe insulin resistance glucose. A global assessment transcriptional changes shows...
Whereas thiazolidinediones (TZDs) are known to rapidly improve insulin action in animals, short durations of TZD therapy have never been studied humans. Among the many actions TZDs, increased circulating levels high molecular weight (HMW) multimer adiponectin may be an important insulin-sensitizing mechanism. We examined effects only 21 days 45 mg pioglitazone (P+) versus placebo (P−) nine subjects with type 2 diabetes (HbA1c, 10.9 ± 0.6%; BMI, 31.9 1.5 kg/m2). Total by approximately twofold...
Abstract Objective To determine and compare the expression of cathepsins K S proteins in joints with rheumatoid arthritis (RA) osteoarthritis (OA) to effect interleukin‐1β (IL‐1β) tumor necrosis factor α (TNFα) on cathepsin fibroblast‐like synoviocytes. Method Expression localization were determined by immunohistochemistry synovium 10 RA‐ 8 OA‐affected joints. Northern Western blot analyses performed analyze primary synoviocyte cultures from RA OA patients. The IL‐1β TNFα secretion...
Impaired cardiac microvascular function contributes to cardiovascular complications in diabetes. Glucagon-like peptide-1 (GLP-1) exhibits potential cardioprotective properties addition its glucose-lowering effect. This study was designed evaluate the impact of GLP-1 on injury diabetes and underlying mechanism involved. Experimental induced using streptozotocin rats. Cohorts diabetic rats received a 12-week treatment vildagliptin (dipeptidyl peptidase-4 inhibitor) or exenatide (GLP-1 analog)....
Particulate matter (PM) is able to induce airway epithelial injury, while the detailed mechanisms remain unclear. Here we demonstrated that PM exposure inactivated MTOR (mechanistic target of rapamycin kinase), enhanced macroautophagy/autophagy, and impaired lysosomal activity in HBE (human bronchial epithelial) cells mouse epithelium. Genetic or pharmaceutical inhibition significantly enhanced, autophagy attenuated, PM-induced IL6 expression cells. Consistently, club-cell-specific deletion...
Abstract Chemokine receptors are a family of G-protein-coupled with key roles in leukocyte migration and inflammatory responses. Here, we present cryo-electron microscopy structures two human CC chemokine receptor–G-protein complexes: CCR2 bound to its endogenous ligand CCL2, CCR3 the apo state. The structure CCL2–CCR2–G-protein complex reveals that CCL2 inserts deeply into extracellular half transmembrane domain, forms substantial interactions receptor through most N-terminal glutamine....
Increased endogenous glucose production (EGP) is a hallmark of type 2 diabetes mellitus. While there evidence for central regulation EGP by activation hypothalamic ATP-sensitive potassium (K(ATP)) channels in rodents, whether these pathways contribute to humans remains be determined. Here we present nervous system that consistent with complementary rodent studies. Oral administration the K(ATP) channel activator diazoxide under fixed hormonal conditions substantially decreased nondiabetic...
Obesity is associated with increased adipose tissue macrophage (ATM) infiltration, and rodent studies suggest that inflammatory factors produced by ATMs contribute to insulin resistance type 2 diabetes. However, a relationship between ATM content has not been clearly established in humans. Since thiazolidinediones attenuate inflammation improve sensitivity, we examined the temporal of effects pioglitazone on these two parameters. The effect 10 21 days treatment sensitivity 26 diabetic...
Crohn's disease (CD) is an intestinal immune-dysfunctional disease. Extracellular vesicles (EVs) are membrane-enclosed particles full of functional molecules, e.g., nuclear acids. Recently, EVs have been shown to participate in the development CD by realizing intercellular communication among cells. However, role carrying double-strand DNA (dsDNA) shed from sites inflammation has not investigated. Here we isolated plasma or colon lavage murine colitis and patients. The level exosomal dsDNA,...
Stepwise degradation of the invariant chain (Ii) is required for binding antigenic peptides to MHC class II molecules. Cathepsin (Cat) L in murine thymus and Cat S peripheral APCs have both been implicated last step Ii that gives rise II–associated (CLIP). V has recently described as highly homologous exclusively expressed human testis, but with no mouse orthologue. We report dominant cysteine protease cortical thymic epithelial cells, while seem be restricted dendritic macrophage-like...
Stepwise degradation of the invariant chain (Ii) is required for binding antigenic peptides to MHC class II molecules. Cathepsin (Cat) L in murine thymus and Cat S peripheral APCs have both been implicated last step Ii that gives rise II–associated (CLIP). V has recently described as highly homologous exclusively expressed human testis, but with no mouse orthologue. We report dominant cysteine protease cortical thymic epithelial cells, while seem be restricted dendritic macrophage-like...
The (1-3)-β-D-Glucan (BG) assay has been approved for making a diagnosis of invasive fungal disease. However, the role serum-BG pneumocystis pneumonia (PCP) is controversial, especially between patients with human immunodeficiency virus (HIV) and non-HIV. We conducted meta-analysis to determine difference overall accuracy PCP in immunocompromised without HIV.After systematic review English-language studies manual researching, sensitivity (Se), specificity (Sp), other measures were pooled...
Macrophage-inducible C-type lectin [Mincle] signalling plays a proinflammatory role in different organs such as the brain and liver, but its intestinal inflammation, including Crohn's disease [CD], remains unknown.The characteristics of Mincle expression CD patients experimental colitis were examined. The functional intestine was addressed models vivo by using knock-out [Mincle-/-] mice. In addition, neutralising anti-Mincle antibody, downstream spleen tyrosine kinase [Syk] inhibitor,...
Abstract Obesity, a global health issue, is associated with numerous diseases and has been shown to affect male reproductive by inducing endocrine hormonal changes, chronic inflammation, oxidative stress epigenetic alterations in cells. This study investigates the impact of obesity on testicular gene expression across mice, monkeys humans, identifying 730 conserved testis-specific genes. High-fat diet-induced upregulates GNG5, INHA, MSH5, SLC30A8 SLC7A4 testes, suggesting their potential as...
Hepatitis B virus (HBV) remains a major global health problem. HBV DNA can be integrated into the human chromosomes. The integration in young cirrhotic chronic hepatitis children has not been explored. This study aims to investigate early childhood cirrhosis. Biopsy liver specimens from and matched non-cirrhotic were collected. was detected through targeted fragment capture sequencing. Twenty 20 with included study. group 14 males 6 females, 13 7 females. Compared children, had lower serum...
Chemotherapy resistance remains a major challenge in cancer treatment. COX-2 (cyclooxygenase 2) is involved drug and poor prognosis of many neoplastic diseases or cancers. However, investigations identifying new modulators pathway searching for chemicals targeting these valid resistant biomarkers are still greatly needed. HCT15, HCT-116, HT-29, COLO205, FHC, IMCE, SW480 cell lines were used to detect the expression YAP COX-2. Site-directed mutagenesis, luciferase reporter analysis ChIP assay...