Whereas thiazolidinediones (TZDs) are known to rapidly improve insulin action in animals, short durations of TZD therapy have never been studied humans. Among the many actions TZDs, increased circulating levels high molecular weight (HMW) multimer adiponectin may be an important insulin-sensitizing mechanism. We examined effects only 21 days 45 mg pioglitazone (P+) versus placebo (P−) nine subjects with type 2 diabetes (HbA1c, 10.9 ± 0.6%; BMI, 31.9 1.5 kg/m2). Total by approximately twofold...

To elucidate the role cAMP-dependent protein kinase (PKA) phosphorylations on tau play in Alzheimer's disease, we have generated highly specific monoclonal antibodies, CP-3 and PG-5, which recognize PKA-dependent of ser214 ser409 respectively. The present study demonstrates by immunohistochemical analysis, PG-5 immunoreactivity with neurofibrillary pathology both early advanced but not normal brain tissue that precede or are coincident initial appearance filamentous aggregates tau. Studies...

Adrenomedullin (AM), a recently discovered hypotensive peptide, is expressed in the endocrine pancreas of different species, as demonstrated by immunocytochemistry. Electron microscopic studies with double immunogold showed colocalization AM and pancreatic polypeptide. A homogeneous expression receptor was found throughout islet using situ hybridization. Six insulin- producing cell lines have been analyzed reverse transcription-PCR both its receptor. Two experimental models used to study...

Abstract : Immunoaffinity‐purified paired helical filaments (PHFs) from Alzheimer's disease (AD) brain homogenates contain an associated protein kinase activity that is able to induce the phosphorylation of PHF proteins on addition exogenous MgCl 2 and ATP. shown be present in immunoaffinity‐purified PHFs both sporadic familial AD, Down's syndrome, Pick's but not normal homogenates. Although initial studies failed show was tau, additional presented this article only cyclic AMP‐dependent...

Methadone Maintenance Therapy (MMT) and detoxification to abstinence are among the most common treatment options for opiate-dependent patients. This paper compares personality traits in detoxified former heroin users those on MMT order assess their relevance selection.Twenty-six formerly heroin-dependent subjects receiving (MM), 33 withdrawn from (MW), 43 healthy controls were compared Millon Clinical Multiaxial Inventory-II (MCMI-II) Temperament Character Inventory (TCI).On TCI, MM patients...

In cerebral ischemia, studies of cell death have focused primarily on neurons, but recent work indicates that ischemia also causes damage to astrocytes. Activation astrocytes is a typical brain response stress stimuli and evidenced by changes in cellular function morphology, as well upregulation glial fibrillary acidic protein. The tumor-suppressor transcription factor p53 has recently been implicated mediator ischemia-induced neuronal death, very little known about its role the activation...

Deposition of amyloid beta protein (Aβ) in extra- and intracellular spaces is one the hallmark pathologies Alzheimer's disease (AD). Therefore, detection presence Aβ AD brain tissue a valuable tool for developing new treatments to prevent progression AD. Several classical binding dyes, fluorochrome, imaging probes, Aβ-specific antibodies have been used detect histochemically tissue. Use these compounds costly time consuming. However, because its intense fluorescent activity, high-affinity,...

The neurofibrillary tau pathology and amyloid deposits seen in Alzheimer's disease (AD) also have been bacteria-infected brains. However, few studies examined the role of these bacteria generation pathology. One suggested link between infection AD is edentulism, complete loss teeth. Edentulism can result from chronic periodontal due to by Enterococcus faecalis. current study assessed ability generate early Alzheimer-like epitopes primary rat cortical neurons through bacterial E. Seven-day...

THE RECOGNITION that nuclear powerplants are competitive with fossil fuel plants and contribute to the control of air pollution holds great growth potential for power. The powerplant, however, possesses contamination environment radioactivity. Consequently, State Federal agencies responsible public health protection increasing their understanding technical aspects reactors surrounding in order plan surveillance programs needed assure continued public's health. authority responsibility...

The potential effect on the public health and environment from proposed operation of major nuclear reactor facilities is now being evaluated by Nuclear Facilities Environmental Analysis Section Division Radiological Health Public Service a routine basis. In past year several reactors in 1200–1600 MW thermal power level have been prior to start construction. Using as typical examples, role providing assistance State agencies environmental problems discussed. This type evaluation stationary...

This paper discusses recent attempts to reproduce thermal shock experiments from 1991 using additional diagnostics. was motivated by an apparent series of neutron bursts which were observed during the deuterium loading titanium powder at cryogenic temperatures. The count rate and temperature measurements are presented for control experimental trials. Some neutrons trials, but magnitude burst this work could not be replicated. Control trials with inert gas, should produce no reaction, also...

This work discusses the ongoing development of diamond-based radiation sensors for spectrometry within environments found in low energy nuclear reaction (LENR) experiments. Specifically discussed are efforts to demonstrate robustness palladium- electrode sensors. includes fabrication methods, characterization and calibration techniques, results deuterium gas loading trials which performance throughout entire test. The positive. One notable peak results; additional required both determine...

The purpose of this paper is to report on the continued work utilizing a palladium electrode diamond sensor in pressurized hydrogen or deuterium environment investigate release radiation during low energy nuclear reactions (LENR). In investigation we conducted long exposure see if delamination occurred due chemical and it was found that after seven days did not delaminate. A run immediately following same some interesting count burst data observed. Further analysis required determine what...

There have been many reports on charged particle and neutron production in LENR experiments but as of yet they not correlated time with excess heat generation. Diamond sensors palladium electrodes can be utilized to address this need. First results using a diamond sensor are presented.