A5101848025- Natural product bioactivities and synthesis
- Pharmacological Effects of Natural Compounds
- Phytochemistry and Biological Activities
- Alkaloids: synthesis and pharmacology
- Phytochemical compounds biological activities
- Rheumatoid Arthritis Research and Therapies
- Plant-based Medicinal Research
- Plant-Microbe Interactions and Immunity
- Virus-based gene therapy research
- Plant Reproductive Biology
- Bioactive Natural Diterpenoids Research
- Adipose Tissue and Metabolism
- Natural Compounds in Disease Treatment
- Traditional and Medicinal Uses of Annonaceae
- Cancer Research and Treatments
- Plant biochemistry and biosynthesis
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Plant Pathogens and Fungal Diseases
- Computational Drug Discovery Methods
- MicroRNA in disease regulation
- Plant Molecular Biology Research
- Immune Cell Function and Interaction
- Circular RNAs in diseases
- Autophagy in Disease and Therapy
Nantong University
2024-2025
Affiliated Hospital of Nantong University
2024-2025
Hainan University
2025
Nanjing Drum Tower Hospital
2015-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Gansu Agricultural University
2021-2024
Kunming University of Science and Technology
2024
Huazhong University of Science and Technology
2022-2024
Tongji Hospital
2022-2024
Qujing Normal University
2014-2024
Rationale: Vascular calcification is a hallmark of atherosclerosis, major cause morbidity and mortality in the United States. We have previously reported that osteogenic transcription factor Runx2 an essential sufficient regulator vascular smooth muscle cells (VSMC) vitro. Objective: To determine contribution differentiation VSMC to pathogenesis function VSMC-derived regulating vivo. Methods Results: SMC-specific Runx2-deficient mice, generated by breeding SM22α-Cre mice with exon 8 floxed...
B-cell acute lymphoblastic leukemia is the most common type of pediatric leukemia. Despite improved remission rates, current treatment regimens for are often associated with adverse effects and central nervous system relapse, necessitating more effective safer agents. Bafilomycin A1 an inhibitor vacuolar H+-ATPase that frequently used at high concentration to block late-phase autophagy. Here, we show bafilomycin a low (1 nM) effectively specifically inhibited killed cells. It targeted both...
Objective— Clinical and experimental studies demonstrate the important roles of vascular smooth muscle cells (VSMC) in pathogenesis atherosclerosis. We have previously determined that osteogenic transcription factor Runx2 is essential for VSMC calcification. The present study characterized Runx2-regulated signals their potential Methods Results— In vivo with atherogenic apolipoprotein E −/− mice demonstrated increased oxidative stress was associated upregulation receptor activator nuclear κB...
The success of future clinical trials with oncolytic viruses depends on the identification and control mechanisms that modulate their therapeutic efficacy. In particular, little is known about role autophagy in infection by attenuated measles virus Edmonston strain (MV-Edm). We investigated interaction between autophagy, innate immune response, activity MV-Edm, since antiviral response a factor limiting virotherapies. report MV-Edm exploits selective to mitigate mediated DDX58/RIG-I like...
Sorafenib is the most widely used first-line drug for treatment of advanced hepatocellular carcinoma (HCC). Unfortunately, sorafenib resistance often limits its therapeutic efficacy. To evaluate efficacy artesunate against sorafenib-resistant HCC and to investigate underlying pharmacological mechanisms, a "sorafenib related gene-ART candidate target" interaction network was constructed, signaling axis consisting with target AFAP1L2 SRC, downstream FUNDC1-dependent mitophagy identified as...
Abstract Background Malignant transformation from hepatic fibrosis to carcinogenesis may be a therapeutic target for hepatocellular carcinoma (HCC). The aim of this study was evaluate anti-cancer efficacy Pien-Tze-Huang (PZH), and investigate the underlying mechanisms by integrating transcriptional regulatory network analysis experimental validation. Methods A diethylnitrosamine (DEN)-induced HCC model in rats established used PZH. After detecting transcriptomic profiling, “disease-related...
// Gang Meng 1 , Mao Xia Diancheng Wang Aiping Chen Yongshan 4 Hongwei Decai Yu 1,2 and Jiwu Wei 1,3 Jiangsu Key Laboratory of Molecular Medicine, Medical School Nanjing University, Nanjing, China 2 The Affiliated Drum Tower Hospital, 3 University Hightech Institute at Suzhou, Veterinary Academy Agricultural Sciences, Correspondence: Wei, email: Yu, Keywords : Newcastle disease virus, mitophagy, apoptosis, autophagy, cancer Received May 29, 2014 Accepted July 13, Published 15, Abstract...
Steroid-induced osteonecrosis of the femoral head (steroid-induced ONFH) presents great challenges due to various effects steroids on multi-system pathways involved into osteoblast differentiation, and osteoclast apoptosis, lipid metabolism, calcium metabolism coagulation. As one most frequently used herbs in Traditional Chinese Medicine formulas that are prescribed for regulation bone mineral therapeutic Achyranthes bidentata steroid-induced ONFH remain unclear. Thus, aim current study was...
Abstract Background Guizhi-Shaoyao-Zhimu decoction (GSZD) has been extensively used for rheumatoid arthritis (RA) therapy. Marked therapeutic efficacy of GSZD acting on RA demonstrated in several long-term clinical trials without any significant side effects. However, its pharmacological mechanisms remain unclear due to a lack appropriate scientific methodology. Methods GSZD’s action were investigated using an integrative approach that combined drug target prediction, network analysis, and...
Protective efficacy of Bacillus Calmette-Guérin (BCG) may be affected by the methods and routes vaccine administration. We have studied safety immunogenicity oral (PO) and/or intradermal (ID) administration BCG in healthy human subjects. No major concerns were detected 68 adults vaccinated with PO ID BCG. Although both could induce systemic Th1 responses capable IFN-γ production, more strongly induced responses. In contrast, stronger mucosal (TB-specific secretory IgA bronchoalveolar lavage...
Abstract Artesunate (ART) has been indicated as a candidate drug for hepatocellular carcinoma (HCC). Glucosylceramidase (GBA) is required autophagic degradation. Whether ART regulates flux by targeting GBA in HCC remains to be defined. Herein, our data demonstrated that the dramatic overexpression of was significantly associated with aggressive progression and short overall survival times HCC. Subsequent experiments revealed an association between activity expression clinical samples, tumor...
Drug-induced liver injury (DILI) remains a serious problem in clinics for both diagnoses and treatment decisions. It is result of accumulated drugs human bodies metabolized into toxic constituents generating reactive metabolites, then arise initial consequences oxidative stress, organelle stress responses lethal (liver necrosis or apoptosis). However, the idiosyncratic nature DILI complexes its mechanistic studies still little known potential etiopathogenesis certain. Single cell omics...
Abstract Serum response factor (SRF) plays vital roles in numerous cellular processes; however, the physiological function of SRF skeletal tissue remains unknown. In several organ systems, regulates expression insulin-like growth factor-1 (IGF-1), which is crucial for normal development mineralized skeleton and bone remodeling throughout life. Here, we show that conditional deletion osteoblasts by osteocalcin-Cre generated viable mice with body size weight. Compared siblings,...
QiXueHe Capsule (QXHC) is a Chinese patent drug that extensively used for the treatment of menstrual disorders. However, its underlying pharmacological mechanisms have not been fully elucidated. A list QXHC putative targets were predicted using MetaDrug. An interaction network links between and known therapeutic disorders was constructed. candidate also identified via calculating topological feature values nodes in network. Additionally, molecular docking simulation performed to determine...
// Jie Peng 1 , Yinghui Wu Zhao Deng Yuanfei Zhou Tongxing Song Yang Xiaming Zhang Tao Xu Mao Xia Anle Cai Zuhong Liu and Jian 1, 2 Department of Animal Nutrition Feed Science, College Science Technology, Huazhong Agricultural University, Wuhan 430070, P. R. China The Cooperative Innovation Center for Sustainable Pig Production, Correspondence to: Peng, email: pengjian@mail.hzau.edu.cn Keywords: miR-377, SIRT1, obesity, inflammation, insulin-resistance Received: January 24,...