A5000240387- Sexual function and dysfunction studies
- Cancer-related molecular mechanisms research
- Intracerebral and Subarachnoid Hemorrhage Research
- Urinary Bladder and Prostate Research
- Head and Neck Surgical Oncology
- Circular RNAs in diseases
- Connexins and lens biology
- RNA modifications and cancer
- Medicinal Plants and Bioactive Compounds
- Hormonal and reproductive studies
- Extracellular vesicles in disease
- Cancer-related gene regulation
- Esophageal and GI Pathology
- Genital Health and Disease
- Meningioma and schwannoma management
- Healthcare and Venom Research
- Brain Metastases and Treatment
- Acupuncture Treatment Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Dysphagia Assessment and Management
- Pain Mechanisms and Treatments
- Reconstructive Surgery and Microvascular Techniques
- Acute Ischemic Stroke Management
- Alzheimer's disease research and treatments
Huashan Hospital
2016-2025
Fudan University
2011-2025
Shanghai Center for Brain Science and Brain-Inspired Technology
2022-2025
Pacific Heart Institute
2017-2025
Jiangmen Central Hospital
2012-2024
Soochow University
2021-2024
First Affiliated Hospital of Soochow University
2021-2024
Hunan Children's Hospital
2019-2024
Shanghai Clinical Research Center
2022-2023
Affiliated Hospital of Nantong University
2018-2022
Brain iron overload plays a detrimental role in brain injury after intracerebral hemorrhage (ICH). A recent study found that minocycline acts as an chelator and reduces iron-induced neuronal death vitro. The present investigated if ICH vivo.This was divided into 4 parts: (1) rats with different sizes of were euthanized 3 days later for serum total edema determination; (2) had treated or vehicle. Serum iron, handling proteins measured; (3) intracaudate injection saline, iron+minocycline,...
Crohn's disease (CD) is an intestinal immune-dysfunctional disease. Extracellular vesicles (EVs) are membrane-enclosed particles full of functional molecules, e.g., nuclear acids. Recently, EVs have been shown to participate in the development CD by realizing intercellular communication among cells. However, role carrying double-strand DNA (dsDNA) shed from sites inflammation has not investigated. Here we isolated plasma or colon lavage murine colitis and patients. The level exosomal dsDNA,...
Diabetic kidney disease (DKD) is one of the most common chronic complications type 2 diabetes mellitus (T2DM), and it particularly important to identify a high-quality method for evaluating progression. Urinary exosomes contain microRNA that might promise early diagnostic monitoring markers DKD. The present study aimed novel exosome-related associated with inflammation fibrosis assess progression DKD.Exosomes were extracted from urine 83 participants determine expression levels miRNA-615-3p...
Roving histopathological imaging in the navigation-confirmed tumor negative margin has not been achieved during neurosurgery procedures. This study aims to explore diagnostic values of a novel intraoperative handheld endomicroscopy DiveScope (DS) for ex vivo glioma diagnosis and roving scan evaluate its safety. prospective pilot was conducted at [university/hospital name] from October 2021 2023, enrolled patients scheduled resection surgery. The DS scanning were compared with frozen section...
To explore the clinical value of apparent diffusion coefficient (ADC), intravoxel incoherent motion (IVIM), and kurtosis imaging (DKI) based on diffusion-weighted MRI (DW-MRI) for predicting genotypes prognostic factors breast cancer. A total 227 patients with cancer confirmed by pathology were reviewed retrospectively. Diffusion-weighted (DWI), IVIM, DKI performed in all patients. The corresponding ADC, true (D), perfusion-related (D*), perfusion fraction (f), mean rate (MD), (MK) measured....
A novel and improved methodology is still required for the diagnosis of diabetic kidney disease (DKD). The aim present study was to identify biomarkers using extracellular vesicle (EV)-derived mRNA based on tissue microarray data.Candidate genes were identified by intersecting differentially expressed (DEGs) eGFR-correlated GEO datasets GSE30528 GSE96804, followed clinical parameter correlation diagnostic efficacy assessment.Fifteen genes, including 8 positively correlated B3GALT2, CDH10,...
Abstract Inflammatory bowel disease (IBD) has emerged a global and the ascending incidence prevalence is accompanied by elevated morbidity, mortality, substantial healthcare system costs. However, current typical one‐size‐fits‐all therapeutic approach suboptimal for proportion of patients due to variability in course IBD considerable number do not have positive response clinically approved drugs, so there still great, unmet demand novel alternative approaches. Spleen tyrosine kinase (Syk),...
Abstract INTRODUCTION Because growing interest has been focusing on cerebral blood flow (CBF) to predict, prevent, and treat Alzheimer's disease (AD), it is important clarify the role of CBF in AD pathology cognitive decline. METHODS In a moyamoya (MMD) cohort, we examined CBF, specific domains, plasma biomarkers, as well correlations among these variables. RESULTS was significantly reduced newly diagnosed MMD patients, while phosphorylated tau181 elevated positively correlated with...
Previous studies have suggested that metformin may improve the survival rate of patients with pancreatic cancer (PC) by regulating adenosine monophosphate‑activated protein kinase/mammalian target rapamycin (mTOR) signaling pathway. Rapamycin specifically targets mTOR. In present study, efficacy and in isolation combination were investigated for treatment PC. The reducing proliferation PC cell line SW1990 vitro vivo was evaluated. It revealed (10 mmol/l) + (2 ng/ml), (15 (20 ng/ml) (200...
Long dormancy period of seeds limits the large-scale artificial cultivation scarce Paris polyphylla var. yunnanensis, an important traditional Chinese medicine. Characterizing miRNAs and their targets is crucial to understanding role during seed in this species. Considering limited genome information species, we first sequenced assembled transcriptome data dormant coats as reference genome. A total 146,671 unigenes with average length 923 bp were identified showed functional diversity based...
Modified Heller's myotomy is still the first choice for achalasia and assessment of surgical outcomes usually made based on subjective sensation patients. This study was to objectively assess long-term esophageal using manometry, 24-hour pH monitoring, scintigraphy fiberoptic esophagoscopy.From February 1979 October 2000, 176 patients with underwent modified myotomy, including alone in 146 patients, combination Gallone or Dor antireflux procedure 22 8 respectively. Clinical score, pressure...
Intraventricular hemorrhage (IVH) is found in approximately 40% of intracerebral hemorrhages and associated with increased mortality poor functional outcome. Cognitive impairment one the complications occurs due to various pathological changes. Amyloid beta (Aβ) accumulation neuroinflammation, Alzheimer disease-like pathology, may contribute cognitive impairment. Iron, degradation product hemoglobin, correlates Aβ. In this study, authors investigated correlation between Aβ enhanced...
The objective of this study was to determine the effects dietary calcium deficiency on process shell formation. Four hundred and fifty female ducks (Anas platyrhynchos) at 22 weeks were randomly assigned three groups. Ducks fed one two calcium-deficient diets (containing 1.8% or 0.38% calcium, respectively) a calcium-adequate control diet 3.6% calcium) for 67 days (depletion period) then all an additional (repletion period). Compared with control, average thickness, egg weight, breaking...
We explored the efficacy and mechanisms of salidroside treatment for erectile dysfunction induced by bilateral cavernous nerve injury (BCNI). Forty male rats were divided into four groups as follows: sham (cavernous nerves exposed only) (S); BCNI (M); + rapamycin (M rapamycin); salidroside). Erectile function in was measured intracavernosal pressure. Penile tissue harvested transmission electron microscopy, immunohistochemistry, immunofluorescence, Masson's trichrome staining,...
Malignant adhesive bowel obstruction caused by peritoneal carcinomatosis is a common complication of advanced abdominal malignancies, and surgical treatment provides little benefit. The present study was undertaken to evaluate the decompression efficacy transnasal ileus tube under X‑ray guidance, with benign patients serving as control group. A total 21 malignant 60 conditions were enrolled between February 2011 March 2015. All treated intubation guidance. 9 cases 44 successfully (42.9 vs....