A5030219544- CNS Lymphoma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Viral-associated cancers and disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Immune Cell Function and Interaction
- Acute Lymphoblastic Leukemia research
- Cancer therapeutics and mechanisms
- Epigenetics and DNA Methylation
- T-cell and Retrovirus Studies
- Lung Cancer Research Studies
- Asymmetric Hydrogenation and Catalysis
- Hematological disorders and diagnostics
- Medicinal Plant Pharmacodynamics Research
- Bone and Joint Diseases
- Protein Degradation and Inhibitors
- Multiple Myeloma Research and Treatments
- Vascular Tumors and Angiosarcomas
- Cancer-related gene regulation
- MRI in cancer diagnosis
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
Huashan Hospital
2016-2025
Fudan University
2016-2025
Shanghai Center for Brain Science and Brain-Inspired Technology
2025
Wuhan University
2024-2025
Shanghai Medical College of Fudan University
2009-2022
Dominican University of California
2020
Rutgers Cancer Institute of New Jersey
2007
Rutgers, The State University of New Jersey
2007
We retrospectively studied a random cohort of patients with cerebral trauma to investigate the risk factors acute kidney injury (AKI) following trauma. AKI was determined using RIFLE (risk, injury, failure, loss, or end-stage kidney) staging criteria. About 171 were chosen in study, 53 group and 118 without non-AKI group. By logistic regression analysis, univariate analysis revealed that age, hypertension, emergent surgery, systemic inflammatory response syndrome (SIRS), Glasgow coma score...
Current synthetic transformations occur readily with starting materials that possess both innate reactivity and steric accessibility or functional-group-oriented reactivity. However, achieving reactions inactive feedstock substrates remains significantly challenging normally requires cumbersome prior functional group manipulations. Herein, we report an unprecedented example of catalytic asymmetric 1,3-dipolar cycloaddition azomethine ylides nonactivated alkenes enabled by copper/ruthenium...
Roving histopathological imaging in the navigation-confirmed tumor negative margin has not been achieved during neurosurgery procedures. This study aims to explore diagnostic values of a novel intraoperative handheld endomicroscopy DiveScope (DS) for ex vivo glioma diagnosis and roving scan evaluate its safety. prospective pilot was conducted at [university/hospital name] from October 2021 2023, enrolled patients scheduled resection surgery. The DS scanning were compared with frozen section...
Purpose: Current prognostic scoring systems for newly diagnosed primary central nervous system lymphoma (PCNSL), such as IELSG score and MSKCC score, are widely used but have limitations in clinical practice. This study aimed to develop a novel model based on real data compare it with existing systems. Patients Methods: A total of 288 patients PCNSL were recruited. randomly allocated the development validation cohorts. The least absolute shrinkage selection operator (LASSO) regression...
This study examined the prevalence, risk factors, and prognosis of epilepsy in patients with primary central nervous system lymphoma (PCNSL) explored necessity prophylactic antiepileptic treatment this population. In retrospective, observational, single-center study, we analyzed clinical data from PCNSL who were diagnosed at our institution between January 2018 April 2023. The cohort comprised 214 (with a median age 62 years), which 128 (47.6%) male. Epilepsy was observed 16.82% (36/214)...
Extranodal NK/T-cell lymphoma (ENKL) is an aggressive hematological malignancy associated with Epstein–Barr virus (EBV) infection. It often resistant to conventional chemotherapy and has a poor prognosis. Icaritin, compound derived from Chinese herbal medicine, Herba Epimedii, been reported exert antitumor effects on variety of cancer cell lines. In the present study, we investigated cytotoxic Icaritin two EBV-positive ENKL lines SNK-10 SNT-8, along underlying molecular mechanisms. SNT-8...
Purpose The systemic immune-inflammation index (SII) has been considered a novel prognostic biomarker in several types of lymphoma. Our aims were to determine the best statistical relationship between pretreatment SII and survival combination Memorial Sloan Kettering Cancer Center model (MSKCC) derive mode primary central nervous system lymphoma (PCNSL). Methods Pretreatment clinical data 174 newly diagnosed PCNSL patients included from two retrospective discovery cohorts (n = 128) one...
Robust EV isolation from CSF by EVTRAP and downstream in-depth phosphoproteome analysis in PCNSL were performed, demonstrating its potential applications.
The pathological diagnosis of primary central nervous system lymphoma (PCNSL) by stereotactic brain biopsy and craniotomy is not often applicable due to the high cost associated complications. In recent years, some biomarkers in cerebrospinal fluid (CSF), including interleukin 10 (IL-10), microRNAs, CXC chemokine ligand 13 (CXCL13), have been reported be with PCNSL. However, this conclusion was controversial. Therefore, study test whether Th17 cell-related cytokines could used distinguish...
Abstract Background Intravitreal methotrexate has been proven to be an effective treatment method for vitreoretinal lymphoma. However, keratopathy occurs as the major side effect during in most cases. The purpose of this study is describe characteristics primary central nervous system lymphoma (PCNSL) with intraocular involvement and attempt reduce incidence caused by intravitreal methotrexate. Methods medical records 22 PCNSL patients (33 eyes) were reviewed. Patients divided into two...
Abstract Background Diffuse large B‐cell lymphoma (DLBCL) patients refractory to rituximab‐based immunochemotherapy have a dismal prognosis. However, the definition of DLBCL remains inconsistent and no cohort study data is available from Asian countries. To validate outcomes in China, we conducted multicenter, retrospective study. Methods The REtrospective AnaLysis Treatment REspoNse (REAL‐TREND) was performed using real‐world 8 centers China. with curative intent were included REAL‐TREND...
High-dose methotrexate (HD-MTX)-based chemotherapy regimen is the first-line treatment of primary central nervous system lymphoma (PCNSL). At present, doses MTX in range 3.5-8 g/m2 are frequently used. However, optimal dose for PCNSL remains controversial. The purpose this real-world study was to compare efficacy and toxicity HD-MTX patients with untreated PCNSL.Immunocompetent adults newly diagnosed between January 2015 December 2018 were investigated followed up June 2019. All patients'...
Background Primary central nervous system lymphoma (PCNSL) is an aggressive extranodal non-Hodgkin with a poor prognosis. We aimed to evaluate the prognostic impact of circulating NK cells in PCNSL. Materials and methods Patients diagnosed PCNSL who were treated at our institution between December 2018 2019 retrospectively screened. Patient variables including age, sex, Karnofsky performance status, diagnostic methods, location lesions, lactate dehydrogenase, cerebrospinal fluids (CSF),...
Introduction: Primary central nervous system lymphoma (PCNSL) is a rare subtype of aggressive extranodal non-Hodgkin lymphoma. Currently, there no standard care for the treatment refractory or relapsed PCNSL (r/r PCNSL). We conducted prospective single-arm phase II study to evaluate zanubrutinib plus cytarabine r/r PCNSL. Methods: Using Simon’s two-stage design, we analyzed 34 patients who received high-dose (3.0 g/m2 once daily) 2 days and (160 mg twice 21 each cycle up 6 cycles. The was...
Purpose: To investigate the frequency and clinical relevance of missense mutation at position 265 changing leucine to proline in myeloid differentiation factor 88 gene (MYD88 L265P) vitreous Chinese patients with vitreoretinal lymphoma (VRL) using droplet digital polymerase chain reaction (ddPCR).Methods: Vitreous fluid (VF) from 29 eyes 20 VRL North Huashan Hospital were included. MYD88 L265P analysis VF was performed ddPCR. Associations between clinicopathologic characteristics analyzed...
Natural killer/T cell lymphoma (NKTCL) is a highly aggressive subtype of non-Hodgkin lymphoma. Gemcitabine, oxaliplatin, and L-asparaginase (GELOX) one the first-line chemotherapy regimens NKTCL. Yet, prognosis NKTCL poor. Icaritin an herb-derived monomer from icariin with antitumor effects. We found that icaritin induced proliferation inhibition apoptosis both in vitro vivo. Moreover, inhibited dissemination RNA sequencing revealed Polo-like kinase 1 (PLK1) gene DNA damage response (DDR) as...
Abstract Background Intracranial plasmacytomas are rare tumors arising from plasma cells with approximately half of the cases progressing to multiple myeloma (MM). However, there is a lack comprehensive clinical cohort analysis on and pathological features, progression, outcomes intracranial plasmacytomas. Methods A retrospective 190 was conducted, combining data 38 in single institution 152 literature. Patient demographics, presentations, tumor locations, imaging surgical treatments,...
Vascular endothelial growth factor (VEGF) is a potent stimulator of angiogenesis and prognostic for many tumors, including those endocrine-responsive tissues such as the breast uterus. In this study, we found that overexpression PEA3 could increase VEGF mRNA levels promoter activity in human T47D SKBR3 cancer cells. Chromatin immunoprecipitation assay demonstrated bind to cells transfected with expression vector. small interfering RNA attenuated binding These results indicated activate transcription.
Objective To investigate the clinical characteristics, diagnostic approaches, short-term efficacy of treatment and prognosis lymphoma patients presenting with a fever unknown origin (FUO). Methods We reviewed records 132 finally diagnosed in Huashan Hospital, half whom initially presented FUO. The other 66 without history FUO were within month when several group also diagnosed. Results predominantly young men (71.21%, p=0.35) characterized by temperature ≥39°C (55/66, 83.33%). Compared...
Primary central nervous system lymphoma (PCNSL) is a rare type of primary extranodal (PEL). MYD88L265P mutation has been observed in up to 75% PCNSL cases, however, the validity and sensitivity digital PCR detecting this remains be elucidated. A total 44 patients, 15 diffuse large B-cell not otherwise specified (DLBCL-NOS) patients 13 other PEL were enrolled present study. The abilities reverse transcription quantitative (RT-qPCR) droplet (ddPCR) detect cerebral spinal fluid (CSF) samples...