A5101929841- Lymphoma Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Ocular Diseases and Behçet’s Syndrome
- Retinoids in leukemia and cellular processes
- Parkinson's Disease Mechanisms and Treatments
- Retinal Diseases and Treatments
- interferon and immune responses
- Retinal Development and Disorders
- Cerebral Venous Sinus Thrombosis
- Intraocular Surgery and Lenses
- Moyamoya disease diagnosis and treatment
- Chronic Lymphocytic Leukemia Research
- Glioma Diagnosis and Treatment
Huashan Hospital
2017-2022
Fudan University
2017-2022
Abstract Background Intravitreal methotrexate has been proven to be an effective treatment method for vitreoretinal lymphoma. However, keratopathy occurs as the major side effect during in most cases. The purpose of this study is describe characteristics primary central nervous system lymphoma (PCNSL) with intraocular involvement and attempt reduce incidence caused by intravitreal methotrexate. Methods medical records 22 PCNSL patients (33 eyes) were reviewed. Patients divided into two...
Purpose: To investigate the frequency and clinical relevance of missense mutation at position 265 changing leucine to proline in myeloid differentiation factor 88 gene (MYD88 L265P) vitreous Chinese patients with vitreoretinal lymphoma (VRL) using droplet digital polymerase chain reaction (ddPCR).Methods: Vitreous fluid (VF) from 29 eyes 20 VRL North Huashan Hospital were included. MYD88 L265P analysis VF was performed ddPCR. Associations between clinicopathologic characteristics analyzed...
Background . The retinal changes have been identified in morphology and function Parkinson’s disease (PD). However, the controversial results suggest that it is incredible only using a single method for testing change to evaluate disease. aim of this study was assess increase diagnostic efficacy with combination multifocal electroretinogram (mf-ERG) spectral domain optical coherence tomography (SD-OCT) examinations. Method Fifty-three PD patients forty-one healthy controls were enrolled....
Purpose: To describe the characteristic manifestations of vitreoretinal lymphoma (VRL) with optical coherence tomography (OCT) and monitor their outcomes after treatmEnt. Patients Methods: primary central nervous system (PCNSL) intraocular involvement were assigned to VRL group. OCT analyzed changes in abnormalities recorded intravitreal methotrexate injections. PCNSL patients without as well (non-VRL group). Results: There 48 eyes high-quality records group, which 19 had abnormal...
To evaluate the diagnostic value of B-scan ultrasound and explore cytological characteristics patients with vitreoretinal lymphoma (VRL) primary central nervous system (PCNSL).The clinical data pathologic specimens from VRL diagnosed at North Huashan Hospital 2016 to 2017 were retrospectively reviewed. The by slit lamp ophthalmoscopy, ultrasound, cytology vitreous, which was obtained vitrectomy, cytokine measurements interleukin (IL)-10 IL-6.Twenty-six eyes (19.4%) out 134 67 (47 men 20...
Abstract Background Vitreoretinal lymphoma (VRL) can commonly masquerade as chronic idiopathic uveitis due to its nonspecific clinical presentation. Thus, early diagnosis is difficult. In this study, new logistic regression models were used classify VRL and uveitis. Additionally, the diagnostic performance of interleukin (IL)‐10, IL‐10/IL‐6, Interleukin Score for IntraOcular Lymphoma Diagnosis (ISOLD) are evaluated. Methods Sixty‐nine aqueous humors (AH) (46 VRL, 23 uveitis) 65 vitreous (VH)...
8577 Background: Recent study showed that the most common gene abnomalities in gastrointestinal MALT lymphoma included 3q26.2 -27,11q23–24 amplifications and t(3;14) (p14.1;q32). shared same aberrations with DLBCL but a lower rate, suggesting clonal transformation from low to high-grade lymphoma. Four important oncogenes were found be involved these aberrations, including PIK3CA, BCL-6, MLL FOXP1. Rare studies about role of expression 4 prognosis seen. Methods: We conducted this research...
Objective To observe the effects of Curcumin on cellular apoptosis rat retinal vascular endothelial cells (RRVEC) induced by high glucose. Methods Generation 4 cultured RRVEC were used in this experiment, and identified with anti-vWF factor antibody immunochemistry immunofluorescence. The divided into control group (5.5 mmol/L glucose), glucose (30 treatment glucose+30 μmol/L Curcumin), respectively. Flow cytometry was to measure reactive oxygen species (ROS) level apoptosis....