A5071336475- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Additive Manufacturing Materials and Processes
- Retinal Diseases and Treatments
- Additive Manufacturing and 3D Printing Technologies
- Retinal Development and Disorders
- Advanced MRI Techniques and Applications
- Botulinum Toxin and Related Neurological Disorders
- Advanced Neuroimaging Techniques and Applications
- Genetic Neurodegenerative Diseases
- Vitamin D Research Studies
- Restless Legs Syndrome Research
- Trigeminal Neuralgia and Treatments
- Dermatologic Treatments and Research
- RNA regulation and disease
- Cerebrovascular and Carotid Artery Diseases
- Cellular and Composite Structures
- Sleep and Wakefulness Research
- Functional Brain Connectivity Studies
- Injection Molding Process and Properties
- Folate and B Vitamins Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Glaucoma and retinal disorders
- Powder Metallurgy Techniques and Materials
- Hair Growth and Disorders
Soochow University
2014-2024
Second Affiliated Hospital of Soochow University
2014-2024
Hunan University
2023-2024
Patients with Parkinson's disease (PD) have elevated levels of brain iron, especially in the nigrostriatal dopaminergic system. The purpose this study was to evaluate iron deposition substantia nigra (SN) and other deep gray matter nuclei PD patients using quantitative susceptibility mapping (QSM) its clinical relationship, explore whether there is a gradient pattern globus pallidus (GP)-fascicula nigrale (FN)-SN pathway.Thirty-three 26 age- sex-matched healthy volunteers (HVs) were included...
Abstract Microglia are the main non-neuronal cells in central nervous system that have important roles brain development and functional connectivity of neural circuits. In physiology, highly dynamic microglial processes facilitated to sense surrounding environment stimuli. Once switches its states, microglia recruited specific sites exert their immune functions, including release cytokines phagocytosis cellular debris. The crosstalk between neurons, stem cells, endothelial oligodendrocytes,...
This study aimed to investigate the cortical complexity and gyrification patterns in Parkinson's disease (PD) using local fractional dimension (LFD) index (LGI), respectively. In a cross-sectional study, LFD LGI 60 PD patients without dementia 56 healthy controls (HC) were investigated brain structural MRI data. estimated Computational Anatomy Toolbox (CAT12) statistically analyzed between groups on vertex level statistical parametric mapping 12 (SPM12). Additionally, correlations changes...
Purpose This study aimed to develop machine learning models for the diagnosis of Parkinson’s disease (PD) using multiple structural magnetic resonance imaging (MRI) features and validate their performance. Methods Brain MRI scans 60 patients with PD 56 normal controls (NCs) were enrolled as development dataset 69 71 NCs from Progression Markers Initiative (PPMI) independent test dataset. First, extracted cerebellar, subcortical, cortical regions brain. Then, Pearson’s correlation least...
Background . The retinal changes have been identified in morphology and function Parkinson’s disease (PD). However, the controversial results suggest that it is incredible only using a single method for testing change to evaluate disease. aim of this study was assess increase diagnostic efficacy with combination multifocal electroretinogram (mf-ERG) spectral domain optical coherence tomography (SD-OCT) examinations. Method Fifty-three PD patients forty-one healthy controls were enrolled....
Abstract Objective This study aimed to assess differences in various scalp parameters between patients with androgenetic alopecia (AGA) and healthy volunteers using 22 MHz ultrasound. Methods Thirty AGA (AGA group) 30 (control who visited the Department of Dermatology at Second Affiliated Hospital Soochow University from September 2021 June 2022 were randomly selected. The met diagnostic criteria outlined Chinese Guidelines for Diagnosis Treatment Androgenetic Alopecia . severity was...
Abstract Objective This study aimed to assess the efficacy of type A botulinum toxin treatment for androgenetic alopecia (AGA) using a combination ultrasound and trichoscopy. Methods Ninety patients with AGA who visited Department Dermatology at Second Affiliated Hospital Soochow University from September 2021 December 2022 were prospectively selected. These met diagnostic criteria outlined in Chinese Guidelines Diagnosis Treatment Androgenetic Alopecia. The severity male ranged between...
Numerous studies have demonstrated that patients with Parkinson's disease (PD) a higher prevalence of substantia nigra (SN) hyperechogenicity compared controls. Our aim was to explore the neuroimaging characteristics transcranial sonography (TCS) PD and those dementia (PDD). The correlation between echogenicity SN clinical symptoms in Chinese PDD also assessed.The ratios (SN+), maximum sizes SN+, widths third ventricle (TV) were measured using TCS for all recruited patients. Data analyzed...
Recent research on Parkinson's disease (PD) has demonstrated the topological abnormalities of structural covariance networks (SCNs) using various morphometric features from magnetic resonance images (sMRI). However, sulcal depth (SD)-based SCNs have not been investigated. In this study, we used SD to investigate alterations in 60 PD patients and 56 age- gender-matched healthy controls (HC). were constructed by thresholding correlation matrices 68 regions analyzed graph theoretical...
To study retinal function defects in type 2 diabetic patients without clinically apparent retinopathy using a multifocal electroretinogram (mf-ERG). Seventy-six eyes of thirty-eight diabetes mellitus(DM) and sixty-four normal thirty-two healthy control (HC) participants were examined mf-ERG. Patients with DM demonstrated an obvious implicit time delay P1 ring 1, 3, 5 compared controls (t = 5.184, p ≤ 0.001; t 8.077, 2.000, 0.047, respectively). The (IT) 4 N1wave was significantly delayed the...
Non-thyroidal illness syndrome (NTIS) is one of the signs for poor prognosis cerebral infarction (CI), but its risk factors had never been explored. In this study, we analyzed potential effect collateral circulation on prediction triiodothyronine large artery atherosclerosis (LAA-CI) patients.Clinical data CI patients between 2012 and 2014 were collected. Imaging inspection was used determining TOAST classification evaluating circulation. One-year follow-up conducted mRS score by...
To observe the changes in thickness of peripapillary retinal nerve fiber layer (pRNFL) and vessel density (pVD) patients with different stages Parkinson's disease (PD).Totally 47 (47 eyes) primary PD were divided into mild group moderate-to-severe according to Hoehn & Yahr (H&Y) stage. Among them, there 27 cases (27 20 (20 group. And who included control healthy people came our hospital for health screening at same time. All participants underwent optical coherence tomography angiography...