A5115594619- MicroRNA in disease regulation
- Angiogenesis and VEGF in Cancer
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Gut microbiota and health
- Histone Deacetylase Inhibitors Research
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- GDF15 and Related Biomarkers
- Groundwater and Isotope Geochemistry
- Dental Radiography and Imaging
- Atmospheric aerosols and clouds
- Atmospheric chemistry and aerosols
- Cancer-related molecular mechanisms research
- Carbon dioxide utilization in catalysis
- Lanthanide and Transition Metal Complexes
- Atmospheric Ozone and Climate
- Bioactive natural compounds
- Numerical methods in engineering
- Dental Research and COVID-19
- Cell Adhesion Molecules Research
- Plant-based Medicinal Research
- Developmental Biology and Gene Regulation
- Electric Vehicles and Infrastructure
- Soybean genetics and cultivation
Institute of Hematology & Blood Diseases Hospital
2024-2025
Baylor College of Medicine
2024-2025
Shanxi Medical University
2024
Air Force Medical University
2012-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Hohai University
2023-2024
Zhejiang University
2024
Shandong First Medical University
2024
Shanghai Medical College of Fudan University
2024
Fudan University
2003-2024
Summary In higher plants, chloroplast and mitochondrial transcripts contain a number of group II introns that need to be precisely spliced before translation into functional proteins. However, the mechanism splicing factors involved in this process are not well understood. By analysing seed mutant maize, we report here identification Empty pericarp16 ( Emp16 ) is required for nad2 intron 4 mitochondria. Disruption function causes developmental arrest embryo endosperm, giving rise an empty...
Haematopoietic stem cells maintain blood production throughout life1. Although extensively characterized using the laboratory mouse, little is known about clonal selection and population dynamics of haematopoietic cell pool during murine ageing. We isolated progenitors from young old mice, identifying 221,890 somatic mutations genome-wide in 1,845 single-cell-derived colonies. Mouse accrue approximately 45 per year, a rate only threefold greater than human despite vastly different organismal...
In this paper, we present a two-grid finite element method (FEM) for two-dimensional nonlinear parabolic integro-differential equation. We solve fully system on coarse grid space with size H and derive rough approximation of the exact solution, then corresponding linearized problem fine h. The optimal error estimates in H1-norm are obtained spatially semidiscrete FEM. Finally, numerical examples given to testify efficiency method.
Introduction Tertiary lymphoid structures (TLSs) are analogues of secondary organs that contain various immune cells. The spatial distribution, maturation and composition TLSs have differential effects on prognosis, the roles in gastric adenocarcinoma (GA) not been revealed. Methods Thus, we evaluated prognostic value GA through analysis bulk RNA sequencing(RNA-seq) data from public databases validated our findings tumour samples Fudan University Shanghai Cancer Center (FUSCC) cohort....
Background Cytomegalovirus (CMV) infection is a common and life-threatening complication following allogeneic haematopoietic stem cell transplantation (allo-HSCT). Letermovir (LET) has been the standard prophylaxis for adult recipients, but studies in children remain limited. Methods We retrospectively analyzed with or without LET after haploidentical donor (HID) Beijing protocol unrelated cord blood (UCB) transplantation. Results Of 151 patients, 67 received LET, including 35 HID recipients...
Macrophages have crucial roles in immune responses and tumor progression, exhibiting diverse phenotypes based on environmental cues. In the present study, impact of cinobufagin (CB) macrophage polarization consequences tumor‑associated behaviors were investigated. Morphological transformations THP‑1 cells into M0, M1 M2 macrophages observed, including distinct changes size, shape adherence properties these cells. CB treatment inhibited viability A549 LLC a concentration‑dependent manner, with an IC
Aim: Peripheral arterial disease (PAD), particularly critical limb ischemia (CLI), is a severe cause of amputation and mortality. More than 50% diabetic patients with CLI die within four to five years. The development novel stem cell therapies may bring new hope these patients. We aimed assess the efficacy autologous bone marrow therapy for treating using meta-analysis.Methods: searched literature in PubMed, Cochrane Central Registry Controlled Trials, Elsevier database EBSCO trials PAD...
Combined curcumin and PS-341 treatment has been reported to enhance cytotoxicity minimize adverse effects through ERK p38MAPK mechanisms in human multiple myeloma cells. However, whether JNK plays similar role this process remains unclear. In the present study, we found combined altered NF-κB p65 expressions distributions H929 Western blot analysis showed inactivated while activated signaling. Pre-treatment with inhibitor SP600125 could attenuate inactivation restored cells’ survival. These...
To study the mechanisms underlying IL‐6‐promoted angiogenic microenvironment in EGFRvIII‐positive glioblastoma, VEGF expression EGFRvIII‐positive/negative tumors was determined by optical molecular imaging. Next, HUVEC tube formation assay, Western blot, qPCR, RNA silencing, chromatin immunoprecipitation, luciferase reporter and ELISA assays were performed to examine role of IL‐6 C/EBPβ tumors. Finally, vitro vivo genistein treatment experiments conducted challenge interaction between...
DNA methylation (DNAm), a major element of epigenetics, plays critical roles in individual development. Reduced representation bisulfite sequencing (RRBS) is an effective and economical method for analyzing the single base. The aims this study were to determine DNAm profiles contexts (CGs non-CGs) lactation dry periods goat mammary glands using RRBS, identify potential milk-related genes. proportion CG was highest among all sequence contexts. levels (72.44% 75.24%) occurred 3' UTR region,...
Lignin, a characteristic component of terrestrial plants. Rivers transport large amounts vascular plant organic matter into the oceans where lignin can degrade over time; however, microorganisms involved in this degradation have not been identified. In study, several bacterial strains were isolated from marine samples using lignin-derived compound vanillic acid (4-hydroxy-3-methoxybenzoic acid) as sole carbon and energy source. The optimum growth temperature for all isolates ranged 30 to...
Dietary intervention has been reported to improve intestinal health. The microbiota of newborn animals plays a fundamental role in the development function and innate immune system. However, little is currently known about dietary interventions gut barrier livestock, especially suckling Bamei piglets. To this end, we studied effect early supplementation on bacterial communities piglets.10 purebred sows were randomly allocated into two groups. In group one, piglets received supplementary milk...
Bone loss caused by mechanical unloading is a threat to prolonged space flight and human health. Epigenetic modifications play crucial role in varied biological processes, but the mechanism of histone modification on unloading-induced bone has rarely been studied. Here, we discovered for first time that methyltransferase Setdb1 was downregulated under both vitro vivo so as attenuate osteoblast proliferation. Furthermore, found these interesting processes depended repression Macrod2...