A5107922973- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Gallbladder and Bile Duct Disorders
- Epigenetics and DNA Methylation
- Advanced MRI Techniques and Applications
- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Natural product bioactivities and synthesis
- Healthcare and Venom Research
- Amino Acid Enzymes and Metabolism
- Ferroptosis and cancer prognosis
- Cervical and Thoracic Myelopathy
- Nursing Roles and Practices
- Restless Legs Syndrome Research
- Spine and Intervertebral Disc Pathology
- Pediatric Hepatobiliary Diseases and Treatments
- Acute Ischemic Stroke Management
- Advanced Computing and Algorithms
- Conducting polymers and applications
- Medical Imaging and Analysis
- Nutrition and Health in Aging
- Menstrual Health and Disorders
- Renal cell carcinoma treatment
- Phytochemistry and Biological Activities
Zhejiang University
2024
Hangzhou Xixi hospital
2024
Yantaishan Hospital
2022-2023
Second Affiliated Hospital of Soochow University
2011-2022
Soochow University
2011-2022
Jinan Central Hospital
2021
Shandong University
2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2013
General Hospital of Shenyang Military Region
2013
Yuanhu Zhitong prescription (YZP) is well known for its analgesic effect. However, multiple bioactive components in vivo remain unclear. In this paper, a rapid resolution liquid chromatography/quadrupole time-of-flight (RRLC-ESI-Q/TOF) was employed to identify the and partial metabolites after oral administration of YZP extracts. Meanwhile, RRLC-ESI-Q/TOF method established validated simultaneous quantification protopine, α-allocryptopine, tetrahydropalmatine, corydaline, tetrahyberberine...
Numerous studies have demonstrated that patients with Parkinson's disease (PD) a higher prevalence of substantia nigra (SN) hyperechogenicity compared controls. Our aim was to explore the neuroimaging characteristics transcranial sonography (TCS) PD and those dementia (PDD). The correlation between echogenicity SN clinical symptoms in Chinese PDD also assessed.The ratios (SN+), maximum sizes SN+, widths third ventricle (TV) were measured using TCS for all recruited patients. Data analyzed...
This study was conducted to investigate the efficacy of pancreatic drainage for pain relief in advanced cancer.Seventy-one patients with carcinoma were divided into two groups: dilated and non-dilated ducts. All underwent endoscopic retrograde cholangiopancreatography (ERCP), biliary stenting stenting. Visual Analog Scale (VAS) scores, remission rates survival time evaluated during follow-up.The post-ERCP VAS score group lower than that at 1 3 months post-ERCP. There no difference 6 months....
To compare the efficacy differences between ginger-separated moxibustion at
Cognitive impairment (CI) is a common but debilitating non-motor symptom in Parkinson's disease (PD). Although cerebrovascular functions are related to cognitive performance healthy individuals, such relation PD remains elusive. This study aims assess the association between function and individuals.Two-hundred-and-one individuals were retrospectively included. They subsequently divided into two groups: with normal cognition (PD-NC) CI (PD-CI). Cerebral hemodynamic characteristics of middle...
Hydrogen sulfide (H2S) is a critical molecule that participates in various molecular, physiological, and pathophysiological processes biological systems. Emerging evidence has revealed H2S implicated the progression of colon cancer immune escape. Against this backdrop, present study aimed to construct prognostic risk feature for adenocarcinoma (COAD) by leveraging hydrogen sulfide-related genes (HSRG). Transcriptomic data corresponding clinical-pathological information were obtained from The...
To explore the early clinical effect and safety of percutaneous transforaminal endoscopic technology for cervical spondylotic radiculopathy.From August 2016 to September 2017, 14 patients with radiculopathy who responded poorly non-surgical treatment at least 6 weeks underwent discectomy via posterior approach. There were males 8 females, aging from 32 68 years old an average (40.5±7.6) years. The course disease ranged 0.5 13.0 months (6.0±1.33) months. lesions involved C₄,₅ in 2 cases, C₅,₆...
Objective To determine the validity of transcranial sonography (TCS) in differential diagnosis Parkinson's disease (PD) and essential tremor (ET). Methods TCS was performed 100 patients with PD, 33 ET normal controls a blind manner. The echo signal intensity substantia nigra classified into grade Ⅰ-Ⅴ for semi-quantitative analysis. When Ⅲ or more, it deemed as abnormal area hyperechogenicity would be measured its ratio to whole midbrain ( S/M ) calculated. Results 1 Semi-quantitative...
Objectives To compare and contrast the characteristics of transcranial sonography(TCS)inmultiple system atrophy(MSA)and Parkinson’s disease(PD), to assess value TCS in diagnosis differential between MSA PD. Methods TCS files were collected 29 patients 45 PD diagnosedby Departmentof Movement Disorders healthy controls.The echogenicity substantia nigra lenticular nucleus, mesencephalic area width third ventricle among three groups analyzed. Results Among groups, rate...
Objective To evaluate the efficacy of pancreatic stenting for pain relief in advanced carcinoma accompanied with duct stricture.Methods ERCP and pancreatiobiliary was performed on 55 cases cancer obstructive jaundice pain.Serum amylase,liver function,visual analog scale (VAS) score,pain rate,Karnofsky performance scores (KPS),and complications were evaluated before after ERCP.Results The total bilirubin,direct bilirubin,ALT,AKP,amylase levels (69.15 ± 10.74) μ mol/L,(47.53 11.02)...
Objective To evaluate the efficacy of Soehendra stent retriever used as a dilator for patients with hilarcholangiocarcinoma. Methods During January 2010 and October 2012, hilarcholangiocareinoma who underwent ERCP were recruited to study. Dilation was attempted by using dilating catheter. If stricture could not be dilated, inserted over wire dilate stricture. Results A total 334 diagnosed having hilarcholangiocarcinoma ERCP. Stricture traversed catheter in 18 cases, prior stenting or ENBD....
Objective To discuss the neuroimaging characteristics of transcranial ultrasound in Parkinson′s disease (PD) patients with or without depression. Methods Transcranial sonography (TCS) was performed PD depression (PDD+ , n=50) (PDD-, n=50), (D, n=50)and healthy controls (n=50), who were enrolled Second Affiliated Hospital Soochow University from September 2010 to July 2016. The differences TCS brainstem raphe (BR) and substantia nigra (SN) four groups analyzed. According degree...
Objective To investigate the substantia nigra(SN) and brainstem raphe(BR) echogenic features of Parkinson′s disease (PD) patients with musculoskeletal pain. Methods A total 115 PD recruited in Second Affiliated Hospital Soochow University from October 2014 to May 2016 were assessed following rating scales: Unified Disease Rating Scale(UPDRS), Hoehn Yahr Staging Scale (H/Y), Hamilton for Depression (HRSD), Beck Inventory Ⅱ(BDI-Ⅱ) Visual Analogue (VAS). All subjects underwent...
Objective To discuss the neuroimaging characteristics of transcranial ultrasound in end-stage renal disease (ESRD) with restless legs syndrome. Methods Transcranial sonography (TCS) was performed ESRD syndrome (RLS+ group, n=41), without (RLS- n=57) and control group (n=47), who were enrolled Second Affiliated Hospital Soochow University from January 2017 to December 2018. The differences TCS substantia nigra (SN), brainstem raphe (BR) red nucleus(RN) among three groups...
To the Editor: Parkinson disease (PD) is second most common neurodegenerative disease, and characterized by both motor non-motor symptoms. The leucine-rich repeat kinase 2 (LRRK2) gene, different mutations among populations, well-known in familial sporadic PD. frequency of G2019S mutation 20% to 40% Ashkenazi Jewish North African Arab while G2385R a risk factor associated with Asian populations. Research teams have found that also PD Chinese Han population, suggesting clear contribution this...
Abstract Background: Sarcopenia is commonly seen in the older adults and increases incidence with age, also Parkinson’ s Disease (PD). There may be a vicious circle between development of PD sarcopenia, but relationship two not clear. We aimed to investigate sarcopenia patients association non-motor symptoms (NMS) PD. Methods: The study included 123 38 age- sex-matched healthy controls. All participants were evaluated for using 2019 Asian Diagnostic Criteria, underwent standard assessments...