Neuroimaging characteristics of transcranial sonography in Parkinson′s disease patients with depression

• DOI: 10.3760/cma.j.issn.1006-7876.2017.07.002
• Publication Date: 2017-07-08
• Authors: Caishan Wang; Yingchun Zhang; Yujing Sheng; Hanbing Chen; Hua Hu; Weifeng Luo
• Keywords: Depression; Echogenicity

Objective To discuss the neuroimaging characteristics of transcranial ultrasound in Parkinson′s disease (PD) patients with or without depression.

Methods Transcranial sonography (TCS) was performed PD depression (PDD+ , n=50) (PDD-, n=50), (D, n=50)and healthy controls (n=50), who were enrolled Second Affiliated Hospital Soochow University from September 2010 to July 2016. The differences TCS brainstem raphe (BR) and substantia nigra (SN) four groups analyzed. According degree depression, PDD+ D divided into three subgroups: mild, moderate severe echo BR analyzed among subgroups.

Results The rate abnormal echogenicity significantly higher (78.0%, 39/50) (82.0%, 41/50) than that PDD- (18.0%, 9/50) control (10.0%, 5/50) (χ2 =87.80, P<0.01), there no statistically significant difference subgroups group, P=0.98; P=0.57). SN hyperechogenicity (80.0%, 40/50) (86.0%, 43/50) (8.0%, 4/50) =110.07, P<0.01).

Conclusion The changes on could provide some useful information for diagnosis differential .

Key words: Ultrasonography, Doppler, transcranial; Parkinson disease; Depression; Substantia nigra; Raphe nuclei