A5101413284- Extraction and Separation Processes
- Analytical chemistry methods development
- Antibiotic Resistance in Bacteria
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Electrochemical Analysis and Applications
- Bacterial biofilms and quorum sensing
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Radioactive element chemistry and processing
- Water Quality Monitoring and Analysis
- Advanced biosensing and bioanalysis techniques
- Genomics and Phylogenetic Studies
- Adipose Tissue and Metabolism
- Metabolism and Genetic Disorders
- Arsenic contamination and mitigation
- Chemical Synthesis and Characterization
- Peroxisome Proliferator-Activated Receptors
- Histone Deacetylase Inhibitors Research
- Liver Disease Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Vibrio bacteria research studies
- Adipokines, Inflammation, and Metabolic Diseases
- Pharmaceutical and Antibiotic Environmental Impacts
- Hybrid Renewable Energy Systems
Shandong First Medical University
2021-2024
Shandong Provincial QianFoShan Hospital
2015-2024
Shandong University
2014-2024
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2021-2023
Union Hospital
2016
Huazhong University of Science and Technology
2016
Xinyang Normal University
2007-2013
Henan University of Technology
2009-2012
Xinxiang University
2008-2010
An early diagnosis of cardiovascular disease is great importance to patients. Herein, a sandwich-type immunosensor for the detection cardiac troponin I (cTnI) prepared by using gold nanoparticles (Au NPs) and composite (CuPtRh CNBs/NH2-Ti3C2) trimetallic hollow CuPtRh cubic nanobox (CNB)-embedded few-layer ultrathin ammoniated MXene (NH2-Ti3C2). The embedding CNBs into NH2-Ti3C2 successfully prevents restacking offers more active sites catalytic H2O2 reduction, which can effectively increase...
Abstract The widespread of different NDM variants in clinical Enterobacterales isolates poses a serious public health concern, which requires continuous monitoring. In this study, three E. coli strains carrying two novel bla NDM-36, -37 were identified from patient with refractory urinary tract infection (UTI) China. We conducted antimicrobial susceptibility testing (AST), enzyme kinetics analysis, conjugation experiment, whole-genome sequencing (WGS), and bioinformatics analysis to...
Objective Nontyphoidal Salmonella is a significant public health concern due to its ability cause foodborne illnesses worldwide. This study aims characterize the nontyphoidal strains isolated from patients in China. Methods A total of 19 were characterized through serovar identification, antimicrobial susceptibility testing (AST), biofilm formation assessment. Genetic relatedness was determined using pulsed-field gel electrophoresis (PFGE). WGS employed decipher resistance mechanism and...
This study aimed to investigate the clinical values of serum alpha-fetoprotein-L3 (AFP-L3) and Golgi protein 73 (GP73) in diagnosis hepatocellular carcinoma (HCC) with low alpha-fetoprotein (AFP). From January 2011 December 2013, 50 low-AFP HCC patients confirmed by color Doppler flow imaging (CDFI) pathological examinations were collected. Forty-five chronic liver diseases also selected, including 29 cirrhosis patients, 15 hepatitis B one severe patient. Furthermore, 100 health volunteers...
Tigecycline serves as one of the last-resort antibiotics to treat severe infections caused by carbapenem-resistant Enterobacterales. Recently, a novel plasmid-mediated resistance-nodulation-division (RND)-type efflux pump gene cluster, TmexCD1-ToprJ1 , and its variants, TmexCD2-ToprJ2 TmexCD3-ToprJ3 encoding tetracyclines tigecycline resistance, were revealed. In this study, we reported three -harboring Klebsiella species strains, collected from two teaching tertiary hospitals in China,...
Allergic asthma is characterized by inflammation and airway remodelling. Airway remodelling with excessive deposition of extracellular matrix (ECM) larger smooth muscle mass are correlated increased responsiveness severity. Calpain a family calcium-dependent endopeptidases, which plays an important role in ECM However, the calpain remains unknown.To investigate asthmatic as well underlying mechanism.The mouse model was made ovalbumin sensitization challenge. conditional knockout mice were...
Abstract Background Insulin resistance (IR) in hepatocytes endangers human health, and frequently results the development of non-alcoholic fatty liver disease (NAFLD). Research on m 6 A methylation RNA molecules has gained popularity recent years; however, molecular mechanisms regulating processes modification IR are not known. The cytochrome P450 (CYP450) enzyme system, which is mainly found liver, associated with pathogenesis NAFLD. However, few studies have been conducted CYP450 related...
BACKGROUND Cardiac fibrosis after primary infarction is a type of pathological phenomena as shown by increased collagen in myocardial cells. Transforming growth factor (TGF)-β1 critical participating fibrosis. A previous study has the inhibitory role on TGF-β1 microRNA-24 (miR-24) via targeting Furin. This thus investigated miR-24 and Furin/TGF-β1 rat MATERIAL AND METHODS total 40 adult SD rats (both males females) were prepared for model ligating descending branch left coronary artery...
Recent studies have demonstrated that the histone deacetylation level was closely related to genesis and development of tumors. Thus, activating acetyltransferases and/or suppressing deacetylases (HDACs) can become an approach for tumor chemotherapy. The acetylation regulation often results in inhibition cell proliferation, induction apoptosis or differentiation, cycle arrest G1 phase. It has been recently traditional anticonvulsant valproic acid efficient class I HDAC inhibitor (HDACI);...
Abstract Background The human immunodeficiency virus type I enhancer binding protein ( HIVEP ) family, which contains zinc finger and acid‐rich (ZAS) domains, has been demonstrated to be implicated in vital biological processes, such as cell survival, tumor necrosis factor (TNF) signaling, formation. However, its expression patterns, prognostic relevance, functional implications acute myeloid leukemia (AML) remain elusive. Methods We inspected mRNA levels datasets from Cancer Genome Atlas...
Carcinoembryonic antigen (CEA) is regarded as one of the crucial tumor markers for colorectal cancer. In this study, we developed snowflake Cu2S/Pd/CuO nanocomposite to construct an original label-free electrochemical immunosensor ultrasensitive detection CEA levels. The cuprous sulfide (Cu2S) with Pd nanoparticles (Pd NPs) was synthesized through in situ formation NPs on Cu2S. Cuprous and CuO can not only be used a carrier increase reaction area but also catalyze substrate generate current...
Background: The prognosis of patients with advanced cervical cancer remains unsatisfactory. A study indicated that transmembrane protein 33 (TMEM33) was implicated in tumor recurrence, while its role has not been elucidated. Methods: TMEM33 expression squamous cell carcinoma and endocervical adenocarcinoma (CESC) primarily screened Cancer Genome Atlas (TCGA), further validated Gene Expression Omnibus (GEO) database. Kaplan-Meier plotter analysis Cox regression were constructed to evaluate...
Twist 1 is highly expressed in adipose tissue and has been associated with obesity related disorders. However, the molecular function of unclear. implicated cell lineage determination differentiation. Therefore, we investigated both role adipocyte precursor mobilization relationship other determinants We examined mRNA protein expression subcutaneous tissues from diet-induced obese C57/BL6 mice Wistar rats patients undergoing liposuction or transplant surgeries. was measured on days 0, 2, 4,...
Abstract Background The prevalence of clinical multidrug-resistant (MDR) Pseudomonas aeruginosa has been increasing rapidly worldwide over the years and responsible for a wide range acute chronic infections with high mortalities. Although hundreds complete genomes P. isolates have sequenced, only few mucoid strains are available, limiting comprehensive understanding this important group opportunistic pathogens. Herein, genome clinically isolated strain JNQH-PA57 was sequenced assembled using...
Histone deacetylation levels are closely associated with the genesis and development of tumors. However, anti-tumor effect mechanism class I histone deacetylase inhibitor sodium valproate (VPA) on hepatocellular carcinoma cells has not been demonstrated clearly. In present study, HepG2 were exposed to VPA, effects VPA proliferation, apoptosis, metastasis invasion evaluated. The MTT method colony assays used detect cell migration Transwell also addition, protein expression matrix...
Peroxisome proliferator-activated receptor γ (PPARγ) is a critical gene that regulates the function of adipocytes. Therefore, studies on molecular regulation mechanism PPARγ are important to understand adipose tissue. Twist 1 another functional in tissue, and hundreds genes regulated by 1. The aim this study was investigate expression 3T3-L1 mature adipocytes.We induced differentiation preadipocytes examined alterations expression. We used agonist pioglitazone antagonist T0070907 effect In...
Insulin resistance (IR) has become a global epidemic that represents serious hazard to public health. However, the precise mechanisms modulating IR have not been fully elucidated. The present study aimed investigate role of transcriptional factor Twist 1 in adipocyte and further explore molecular mechanism. An vitro model based on cultured 3T3-L1 adipocytes was established under high glucose/insulin stimulation an vivo C57/BL6J mice induced by fat diet (HFD) also developed. Lentivirus...
Abstract Metabolic diseases have become a major threat to human health worldwide as result of changing lifestyles. The exploration the underlying molecular mechanisms metabolic and development improved therapeutic methods been hindered by lack appropriate experimental models. Organoids are three‐dimensional in vitro models self‐renewing cells that spontaneously self‐organize into structures similar corresponding vivo tissues, recapitulating original tissue function. Off‐body organoid...
The level of histone deacetylation is closely associated with the genesis and development tumors, but antitumor effect mechanism class I deacetylase inhibitor (HDACI) valproate acid sodium (VPA) on hepatocellular carcinoma cells has not been clearly demonstrated. In present study, VPA were measured in vitro. Firstly, it was found that, as an HDAC inhibitor, could inhibit activity HDAC1 gene expression and, a result, inhibition cell proliferation detected by MTT assay. Subsequently, cycle...
Hepatocellular carcinoma (HCC) is one of the most malignant tumors with persistently high morbidity and mortality. However, expression, prognostic clinical significance FAM189 family genes in HCC remain largely unknown. In this study, expression levels were analyzed through TCGA-LIHC ICGC-LIRI-JP cohorts, further validated multiple independent GEO datasets. It was found that FAM189B significantly upregulated tumor tissues, while FAM189A1 FAM189A2 not changed between adjacent tissues. Further...