A5024929346- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Research in Cotton Cultivation
- Plant and Fungal Interactions Research
- Biosensors and Analytical Detection
- Advanced biosensing and bioanalysis techniques
- Colorectal Cancer Treatments and Studies
- Clostridium difficile and Clostridium perfringens research
- Gastric Cancer Management and Outcomes
- Plant Virus Research Studies
- Colorectal Cancer Surgical Treatments
- Innovation and Knowledge Management
- Advanced Computational Techniques and Applications
- Cancer Genomics and Diagnostics
- Public-Private Partnership Projects
- Colorectal and Anal Carcinomas
- Cancer therapeutics and mechanisms
- COVID-19 Clinical Research Studies
- Genetic factors in colorectal cancer
- Viral gastroenteritis research and epidemiology
- Semantic Web and Ontologies
- Gut microbiota and health
- Service-Oriented Architecture and Web Services
Shanxi Provincial Cancer Hospital
2015-2025
Shenzhen Bao'an District People's Hospital
2024
Tangshan People's Hospital
2024
First Hospital of Jilin University
2024
Jilin University
2024
Jinan Central Hospital
2016-2023
Shandong First Medical University
2020-2023
Dalian Polytechnic University
2012-2022
Shanxi Medical University
2015-2022
Shandong University
2004-2020
Two draft sequences of Gossypium hirsutum, the most widely cultivated cotton species, provide insights into genome structure, rearrangement, gene evolution and fiber biology. hirsutum has proven difficult to sequence owing its complex allotetraploid (AtDt) genome. Here we produce a using 181-fold paired-end assisted by fivefold BAC-to-BAC high-resolution genetic map. In our assembly 88.5% 2,173-Mb scaffolds, which cover 89.6%∼96.7% AtDt genome, are anchored oriented 26 pseudochromosomes....
Abstract Corona Virus Disease 2019 (COVID-19) is a recently emerged life-threatening disease caused by SARS-CoV-2. Real-time fluorescent PCR (RT-PCR) the clinical standard for SARS-CoV-2 nucleic acid detection. To detect early and control spreading on time, faster more convenient method detecting, RT-LAMP (reverse transcription loop-mediated isothermal amplification) was developed. RNA reverse amplification were performed in one step at 63 °C conditions, results can be obtained within 30...
J o u r n a l P e -p f patients in the iruplinalkib group (median PFS, 27.7 months [95% CI, crizotinib group; HR, 0.34 [98.02% 0.23-0.52];p<0.0001).The ORR assessed by IRC was 93.0% (95% 87.5-96.6) and 89.3% 83.1-93.7) group.The intracranial 90.9% (10/11, 95% 58.7-99.8) 60.0% (9/15, 32.3-83.7) for with measurable baseline CNS metastases.Incidence of grade 3 or 4 treatment-related adverse events 51.7% 49.7% group.Interpretation: Iruplinalkib demonstrated significantly improved PFS antitumor...
Abstract The present study aimed to determine the differences in gut microbiota between patients with chronic kidney disease ( CKD ) and healthy controls HC search for better microbial biomarkers associated . 16S rRNA gene sequencing approach was used investigate groups. found that 12 phylotypes were overrepresented group 19 at genus level. Furthermore, genera Lachnospira Ruminococcus_gnavus performed best differentiating populations. In addition, this novel Holdemanella , Megamonas...
We conducted a proof-of-concept, phase 2 trial to assess neoadjuvant SHR-1701 with or without chemotherapy, followed by surgery radiotherapy, and then consolidation in unresectable stage III non-small-cell lung cancer (NSCLC). In the primary cohort of patients receiving combination therapy (n = 97), both endpoints were met, post-induction objective response rate 58% (95% confidence interval [CI] 47–68) an 18-month event-free survival (EFS) 56.6% CI 45.2–66.5). Overall, 27 (25%) underwent...
The early detection and differential diagnosis of respiratory infections increase the chances for successful control COVID-19 disease. nucleic acid RT-PCR test is regarded as current standard molecular diagnosis. However, maximal specificity confirmation target ORF1ab gene considered to be less sensitive than other targets in clinical application. In addition, recent evidence indicated that initial missed asymptomatic patients with SARS-CoV-2 discharged “re-examination positive” might due...
Iruplinalkib (WX-0593) is an anaplastic lymphoma kinase (ALK)/c-ros oncogene 1 (ROS1) tyrosine inhibitor. Here we reported the single-arm, phase II study (INTELLECT) results of efficacy and safety iruplinalkib for ALK-positive crizotinib-resistant advanced non-small cell lung cancer (NSCLC) patients.ALK-positive NSCLC patients aged ≥18 years, with Eastern Cooperative Oncology Group performance status 0-2 were eligible. Patients received 180 mg orally once daily a 21-day cycle 7-day lead-in...
Denosumab (Xgeva®) is a standard treatment for the prevention of skeletal-related events (SREs) in patients with bone metastases (BM). This trial was designed to assess equivalence LY01011 denosumab terms efficacy and safety. Eligible BM from solid tumors were randomized at 1:1 ratio receive 120 mg or subcutaneously every four weeks during 12-week double-blind period, then all enrolled continued until week 53. The primary endpoint natural logarithm change urinary N-terminal crosslinked...
During reservoir numerical simulation, Darcy's law is usually used for splitting flow rates based on formation capacity, without considering the effects of threshold pressure gradient low permeability. So rate split layer not consistent with actual production, which results in poor history matching precision. Injection and production profiles are best information determining individual layer. The result improved by utilizing injection logs. This paper presents method injection-and-production...
Considering the advantages of single nucleotide polymorphisms (SNP) in genotyping and variety identification, first set public SNP markers at Cotton Marker Database (http://www.cottonmarker.org/) were validated screened across standard varieties cotton distinctness, uniformity stability (DUS) test, aiming to obtain an appropriate core suitable for upland cultivars China. A total 399 out 1 005 SNPs from 270 loci including 170 insertions-deletions (InDels) evaluated their among 30 using Sanger...
Histone deacetylation levels are closely associated with the genesis and development of tumors. However, anti-tumor effect mechanism class I histone deacetylase inhibitor sodium valproate (VPA) on hepatocellular carcinoma cells has not been demonstrated clearly. In present study, HepG2 were exposed to VPA, effects VPA proliferation, apoptosis, metastasis invasion evaluated. The MTT method colony assays used detect cell migration Transwell also addition, protein expression matrix...
Abstract Background Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD), the pathogenesis of which complicated, and it difficult to treat. In recent years, emerging fecal microbiota transplantation (FMT) has shown good effects in UC treatment therefore accepted by increasing numbers patients. Our hospital carried out FMT since 2017, achieved results treatment. We have found our clinical work that efficacy re-FMT after recurrence decreased. This difference from reported...
Abstract Background: Garsorasib (D-1553), a potent KRAS G12C inhibitor, has previously demonstrated promising anti-tumor activity in G12C-mutated non-small-cell lung cancer (NSCLC) phase 1 study. Here we present the efficacy and safety of garsorasib pivotal 2 Methods: In this open-label, multicenter, single-arm study, patients received 600 mg twice daily 21-day cycles. Eligible criteria included with locally advanced or metastatic NSCLC harboring mutation, who had disease progression after...
8082 Background: Consolidation immunotherapy after chemoradiation is the standard of care for unresectable stage III NSCLC. Addition immunotherapy-based induction treatment may further improve outcome, partly by enabling surgery. We conducted a proof-of-concept, phase 2 trial to assess neoadjuvant SHR-1701 (an anti-PD-L1/TGF-β bifunctional fusion protein) with or without chemotherapy, followed surgery radiotherapy in NSCLC and EGFR/ ALK alterations. Methods: Patients MDT-assessed surgically...
This paper aims to put forward an approach verify the feasible degree of information system development engineering project and indentify key risk factors in process development. Firstly, six factors, which have been paid great attention management area, are chosen as independent random variables. Then we use Crystal ball software fit a probablity distribution for each factor, also structural equation modeling method is adopted establish mathematical formula between performance. Finally, run...
Abstract Background: In absence of effective vaccines, infection prevention and control SARS-CoV-2 through diagnostic testing quarantine is critical. Early detection differential diagnosis respiratory infections increases the chances for successful COVID-19 disease. The nucleic acid RT-PCR test regarded as current standard molecular with high sensitivity. However, highest specificity confirmation target ORF1ab gene considered to be less sensitive than other targets in clinical application....
Forty core primers were used to construct a DNA fingerprint database of 132 cotton species based on multiplex fluorescence detection technology.A high first successful ratio 99.04% was demonstrated with tetraplex polymerase chain reaction.Forty primer pairs amplified total 262 genotypes among species, an average 6.55 per and values polymorphism information content varying from 0.340 0.882.Conflicting homozygous ratios found in various species.The highest landrace standard cultivars, which...
We have recently demonstrated that adeno-associated virus serotype 9 (AAV9)-mediated human erythropoietin (hEPO) gene delivery into the brain protects dopaminergic (DA) neurons in substantia nigra a rat model of Parkinson's disease. In present study, we examined whether pre-exposure to AAV9-hEPO vectors with an intramuscular or intrastriatal injection would reduce AAV9-mediated hEPO transduction brain. first characterized transgene expression and immune responses against striatum at 4 days,...
The antitumor function of fungal polysaccharides is a popular area interest in the research field due to their high efficiency and low side effects. main mechanism immune enhancement. polysaccharose (APS‑3) was extracted from fruit body Phellinus pullus. proliferation inhibition mouse sarcoma 180 (S180) tumor cells studied by MTT method. Mice models transplanted S180 were established treated with APS‑3 verify activity vivo. Natural killer (NK) lymphokine‑activated (LAK) cytotoxicities mice...